2-(2-Methoxyphenyl)-3-((Piperidin-1-yl)ethyl)thiazolidin-4-One-Loaded Polymeric Nanocapsules: In Vitro Antiglioma Activity and In Vivo Toxicity Evaluation

[1]  F. Stefanello,et al.  Synthetic 2-aryl-3-((piperidin-1-yl)ethyl)thiazolidin-4-ones exhibit selective in vitro antitumoral activity and inhibit cancer cell growth in a preclinical model of glioblastoma multiforme. , 2017, Chemico-biological interactions.

[2]  C. Luchese,et al.  Polymeric nanocapsules as a technological alternative to reduce the toxicity caused by meloxicam in mice. , 2016, Regulatory toxicology and pharmacology : RTP.

[3]  N. Finiuk,et al.  5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells. , 2016, European journal of medicinal chemistry.

[4]  Pui-Yu Ho,et al.  Doxorubicin-loaded biodegradable self-assembly zein nanoparticle and its anti-cancer effect: Preparation, in vitro evaluation, and cellular uptake. , 2016, Colloids and surfaces. B, Biointerfaces.

[5]  R. Stoika,et al.  Putative anticancer potential of novel 4-thiazolidinone derivatives: cytotoxicity toward rat C6 glioma in vitro and correlation of general toxicity with the balance of free radical oxidation in rats , 2016, Croatian medical journal.

[6]  S. Moorkoth.  Synthesis and Anti-cancer Activity of Novel Thiazolidinone Analogs of 6-Aminoflavone. , 2015, Chemical & pharmaceutical bulletin.

[7]  Borisov Ke,et al.  The immunosuppressive microenvironment of malignant gliomas , 2015 .

[8]  Xuben Hou,et al.  Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors. , 2015, Bioorganic & medicinal chemistry.

[9]  K. E. Borisov,et al.  [The immunosuppressive microenvironment of malignant gliomas]. , 2015, Arkhiv patologii.

[10]  L. Tasso,et al.  Beclomethasone Dipropionate-Loaded Polymeric Nanocapsules: Development, In Vitro Cytotoxicity, and In Vivo Evaluation of Acute Lung Injury. , 2015, Journal of nanoscience and nanotechnology.

[11]  S. Ljubisavljevic.  Oxidative Stress and Neurobiology of Demyelination , 2014, Molecular Neurobiology.

[12]  A. Abdelazeem,et al.  Design, synthesis and biological evaluation of novel diphenylthiazole-based cyclooxygenase inhibitors as potential anticancer agents. , 2014, Bioorganic chemistry.

[13]  M. Fil,et al.  Study of antineoplastic action of novel isomeric derivatives of 4-thiazolidinone. , 2014, Ukrainian biochemical journal.

[14]  B. Mukherjee,et al.  Preparation and characterization of Tamoxifen citrate loaded nanoparticles for breast cancer therapy , 2014, International journal of nanomedicine.

[15]  S. H. Alves,et al.  Formulation and in vitro evaluation of coconut oil-core cationic nanocapsules intended for vaginal delivery of clotrimazole. , 2014, Colloids and surfaces. B, Biointerfaces.

[16]  A. Verma,et al.  4-Thiazolidinones: the advances continue…. , 2014, European journal of medicinal chemistry.

[17]  R. Ransohoff,et al.  Development, maintenance and disruption of the blood-brain barrier , 2013, Nature Medicine.

[18]  G. Debom,et al.  Ketoprofen-loaded polymeric nanocapsules selectively inhibit cancer cell growth in vitro and in preclinical model of glioblastoma multiforme , 2013, Investigational New Drugs.

[19]  S. Hübner,et al.  Synthesis, antifungal and cytotoxic activities of 2-aryl-3-((piperidin-1-yl)ethyl)thiazolidinones. , 2013, European journal of medicinal chemistry.

[20]  Alexander D. MacKerell,et al.  Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling. , 2013, Organic & biomolecular chemistry.

[21]  S. Guterres,et al.  Poly(ϵ-caprolactone) microcapsules and nanocapsules in drug delivery , 2013, Expert opinion on drug delivery.

[22]  M. Mrugala,et al.  Advances and challenges in the treatment of glioblastoma: a clinician's perspective. , 2013, Discovery medicine.

[23]  R. Cetin-Atalay,et al.  A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells. , 2012, Bioorganic & medicinal chemistry.

[24]  Prabhaker Walmik,et al.  Synthesis, Antioxidant and Antimicrobial Evaluation of Thiazolidinone, Azetidinone Encompassing Indolylthienopyrimidines. , 2012 .

[25]  Prabhaker Walmik,et al.  Synthesis, antioxidant and antimicrobial evaluation of thiazolidinone, azetidinone encompassing indolylthienopyrimidines , 2012, Journal of Chemical Sciences.

[26]  P. Kumari,et al.  Synthesis and biological evaluation of some thiazolidinones as antimicrobial agents. , 2012, European journal of medicinal chemistry.

[27]  A. Date,et al.  Eudragit EPO nanoparticles: application in improving therapeutic efficacy and reducing ulcerogenicity of meloxicam on oral administration. , 2011, Journal of biomedical nanotechnology.

[28]  A. Deep,et al.  Synthesis of 2-(aryl)-5-(arylidene)-4-thiazolidinone derivatives with potential analgesic and anti-inflammatory activity , 2011, Medicinal Chemistry Research.

[29]  A. Date,et al.  Positively charged polymeric nanoparticles: application in improving therapeutic efficacy of meloxicam after oral administration. , 2011, Die Pharmazie.

[30]  Simoní Da Ros,et al.  Nanostructured Systems Containing Rutin: In Vitro Antioxidant Activity and Photostability Studies , 2010, Nanoscale research letters.

[31]  S. Guterres,et al.  Nanoencapsulation as a way to control the release and to increase the photostability of clobetasol propionate: influence of the nanostructured system. , 2009, Journal of biomedical nanotechnology.

[32]  R. Lesyk,et al.  Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity. , 2009, European journal of medicinal chemistry.

[33]  C. Kavitha,et al.  Synthesis of 2-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid derivatives and evaluation of their cytotoxicity and induction of apoptosis in human leukemia cells. , 2009, Bioorganic & medicinal chemistry.

[34]  R. Gonsette.  Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity , 2008, Journal of the Neurological Sciences.

[35]  S. Guterres,et al.  Tretinoin-loaded nanocapsules: Preparation, physicochemical characterization, and photostability study. , 2008, International journal of pharmaceutics.

[36]  S. Guterres,et al.  Development and physicochemical characterization of dexamethasone-loaded polymeric nanocapsule suspensions , 2008 .

[37]  R. Chari,et al.  Targeted cancer therapy: conferring specificity to cytotoxic drugs. , 2008, Accounts of chemical research.

[38]  R. Soffietti,et al.  New developments in the treatment of malignant gliomas , 2007, Expert review of neurotherapeutics.

[39]  B. Scheithauer,et al.  The 2007 WHO Classification of Tumours of the Central Nervous System , 2007, Acta Neuropathologica.

[40]  Mark R Gilbert,et al.  Chemoradiotherapy in malignant glioma: standard of care and future directions. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[41]  B. Scheithauer,et al.  The 2007 WHO classification of tumours of the central nervous system , 2007, Acta Neuropathologica.

[42]  L. Vassilev,et al.  Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors. , 2007, Bioorganic & medicinal chemistry letters.

[43]  Duane D. Miller,et al.  Structure-activity relationship studies of arylthiazolidine amides as selective cytotoxic agents for melanoma. , 2007, Anticancer research.

[44]  W. Curry,et al.  Focus on TILs: Prognostic significance of tumor infiltrating lymphocytes in human glioma. , 2007, Cancer immunity.

[45]  Hongmao Sun,et al.  Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[46]  R. Lesyk,et al.  4-Thiazolidones: Centenarian History, Current Status and Perspectives for Modern Organic and Medicinal Chemistry , 2004 .

[47]  Junying Yuan,et al.  A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. , 2002, Journal of the American Chemical Society.

[48]  E. Holland.  Progenitor cells and glioma formation , 2001, Current opinion in neurology.

[49]  W. Markesbery,et al.  Changes in thiol content and expression of glutathione redox system genes in the hippocampus and cerebellum in Alzheimer's disease , 2001, Neuroscience Letters.

[50]  T. Mitchison,et al.  Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL , 2001, Nature Cell Biology.

[51]  H. Esterbauer,et al.  Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. , 1990, Methods in enzymology.

[52]  H. Aebi,et al.  Catalase in vitro. , 1984, Methods in enzymology.

[53]  I. Fridovich,et al.  The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. , 1972, The Journal of biological chemistry.

[54]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.