PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway.

[1]  Min Young Kim,et al.  Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells. , 2011, Biochemical and biophysical research communications.

[2]  E. Barroso,et al.  The peroxisome proliferator-activated receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1. , 2011, Biochemical pharmacology.

[3]  C. Walline,et al.  Peroxisome proliferator‐activated receptor δ agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis , 2010, Immunology.

[4]  C. Thiemermann,et al.  ACTIVATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-&bgr;/&dgr; ATTENUATES MYOCARDIAL ISCHEMIA/REPERFUSION INJURY IN THE RAT , 2010, Shock.

[5]  Won Hee Lee,et al.  Irradiation induces regionally specific alterations in pro-inflammatory environments in rat brain , 2010, International journal of radiation biology.

[6]  Gang Wu,et al.  Anti-inflammatory effects of tanshinone IIA on radiation-induced microglia BV-2 cells inflammatory response. , 2009, Cancer biotherapy & radiopharmaceuticals.

[7]  D. Bishop-Bailey,et al.  Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation. , 2009, Pharmacology & therapeutics.

[8]  F. Hsu,et al.  The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation. , 2009, International journal of radiation oncology, biology, physics.

[9]  S. Kalinin,et al.  A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease. , 2009, Current Alzheimer research.

[10]  Susan M. Chang,et al.  Quality of life in adults with brain tumors: current knowledge and future directions. , 2009, Neuro-oncology.

[11]  J. Mitchell,et al.  PPAR / Agonists Modulate Platelet Function via a Mechanism Involving PPAR Receptors and Specific Association / Repression of PKC , 2009 .

[12]  F. Hsu,et al.  PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways. , 2008, Free radical biology & medicine.

[13]  W. Wahli,et al.  Activation of Peroxisome Proliferator–Activated Receptor β/δ Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor-κB Activity via Extracellular Signal–Related Kinase 1/2 , 2008, Diabetes.

[14]  Didier Grillot,et al.  Identification and Characterization of a Selective Peroxisome Proliferator-Activated Receptor β/δ (NR1C2) Antagonist , 2008 .

[15]  D. Spitz,et al.  Inhibiting catalase activity sensitizes 36B10 rat glioma cells to oxidative stress. , 2007, Free radical biology & medicine.

[16]  A. Iwashita,et al.  Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor δ-Selective Agonists in Vitro and in Vivo , 2007, Journal of Pharmacology and Experimental Therapeutics.

[17]  Jonathan R. Whitlock,et al.  Learning Induces Long-Term Potentiation in the Hippocampus , 2006, Science.

[18]  D. Bishop-Bailey,et al.  Peroxisome proliferator-activated receptors and inflammation. , 2006, Pharmacology & therapeutics.

[19]  E. Shaw,et al.  Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[20]  P. Brown,et al.  Role and relevance of neurocognitive assessment in clinical trials of patients with CNS tumors. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[21]  P. Brown,et al.  Whole-brain radiotherapy in the management of brain metastasis. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[22]  L. Rochette,et al.  Peroxisome proliferator-activated receptor δ (PPARδ) activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis , 2006 .

[23]  E. Shaw,et al.  The management of radiation-induced brain injury. , 2006, Cancer treatment and research.

[24]  W. Wahli,et al.  PPARs in diseases: control mechanisms of inflammation. , 2005, Current medicinal chemistry.

[25]  J. de Vellis,et al.  Microglia in health and disease , 2005, Journal of neuroscience research.

[26]  J. Peters,et al.  Peroxisome Proliferator-activated Receptor-β/δ Inhibits Epidermal Cell Proliferation by Down-regulation of Kinase Activity* , 2005, Journal of Biological Chemistry.

[27]  W. Wahli,et al.  Peroxisome proliferator-activated receptor β/δ activation inhibits hypertrophy in neonatal rat cardiomyocytes , 2005 .

[28]  S. Moreno,et al.  Immunolocalization of peroxisome proliferator-activated receptors and retinoid x receptors in the adult rat CNS , 2004, Neuroscience.

[29]  Steven A. Smith,et al.  Effect of the peroxisome proliferator‐activated receptor β activator GW0742 in rat cultured cerebellar granule neurons , 2004, Journal of neuroscience research.

[30]  S. Kohsaka,et al.  Protein kinase Cα requirement in the activation of p38 mitogen-activated protein kinase, which is linked to the induction of tumor necrosis factor α in lipopolysaccharide-stimulated microglia , 2004, Neurochemistry International.

[31]  Hiroki Toda,et al.  Inflammatory Blockade Restores Adult Hippocampal Neurogenesis , 2003, Science.

[32]  K. Hole,et al.  Radiological and clinical assessment of long-term brain tumour survivors after radiotherapy. , 2003, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[33]  B. Staels,et al.  Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation , 2003, The Journal of Steroid Biochemistry and Molecular Biology.

[34]  E. Malle,et al.  Vitamin E (alpha-tocopherol) attenuates cyclo-oxygenase 2 transcription and synthesis in immortalized murine BV-2 microglia. , 2003, The Biochemical journal.

[35]  J. Sloan,et al.  Quality of life measurements: a soft outcome--or is it? , 2002, The American journal of managed care.

[36]  Jacqueline P. Williams,et al.  Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. , 2002, Brain research. Molecular brain research.

[37]  M. Lynch,et al.  Neuroprotective Effect of Eicosapentaenoic Acid in Hippocampus of Rats Exposed to γ-Irradiation* , 2002, The Journal of Biological Chemistry.

[38]  W. Forrester,et al.  A DNA vector-based RNAi technology to suppress gene expression in mammalian cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[39]  P. Gebicke-haerter.  Microglia in neurodegeneration: Molecular aspects , 2001, Microscopy research and technique.

[40]  T. Herdegen,et al.  AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration , 2001, Oncogene.

[41]  J. Pocock,et al.  Microglial signalling cascades in neurodegenerative disease. , 2001, Progress in brain research.

[42]  S. Jander,et al.  The role of microglia and macrophages in the pathophysiology of the CNS , 1999, Progress in Neurobiology.

[43]  K. Umesono,et al.  A Unified Nomenclature System for the Nuclear Receptor Superfamily , 1999, Cell.

[44]  M. O’Banion,et al.  TNFα and IL-1β mediate intercellular adhesion molecule-1 induction via microglia–astrocyte interaction in CNS radiation injury , 1999, Journal of Neuroimmunology.

[45]  C. Marshall,et al.  Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes , 1998, Molecular and Cellular Biology.

[46]  A. Stalder,et al.  Delayed molecular responses to brain irradiation. , 1997, International journal of radiation biology.

[47]  E. Neuwelt,et al.  Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[48]  Walter Kolch,et al.  Protein kinase Cα activates RAF-1 by direct phosphorylation , 1993, Nature.

[49]  K. Umesono,et al.  Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors , 1992, Nature.