Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation

[1]  P. Waterhouse,et al.  TIMPs: versatile extracellular regulators in cancer , 2016, Nature Reviews Cancer.

[2]  R. Olszanecki,et al.  Is Urinary NGAL Determination Useful for Monitoring Kidney Function and Assessment of Cardiovascular Disease? A 12-Month Observation of Patients with Type 2 Diabetes , 2016, Disease markers.

[3]  M. Yousefi,et al.  Role of oral microbiome on oral cancers, a review. , 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[4]  B. Kędra,et al.  Expressions of Matrix Metalloproteinases 2, 7, and 9 in Carcinogenesis of Pancreatic Ductal Adenocarcinoma , 2016, Disease markers.

[5]  C. Tripodo,et al.  C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation , 2016, Nature Communications.

[6]  Michael Elkin,et al.  Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model , 2015, Oncotarget.

[7]  R. Radhakrishnan,et al.  The role of MMP-2 and MMP-9 as prognostic markers in the early stages of tongue squamous cell carcinoma. , 2015, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[8]  T. Salo,et al.  Matrix metalloproteinase 8 degrades apolipoprotein A‐I and reduces its cholesterol efflux capacity , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  P. Cossart,et al.  How bacterial pathogens colonize their hosts and invade deeper tissues. , 2015, Microbes and infection.

[10]  S. Swarnakar,et al.  Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants. , 2014, World journal of biological chemistry.

[11]  R. Rautemaa,et al.  Intracellular localization of Treponema denticola chymotrypsin-like proteinase in chronic periodontitis , 2014, Journal of oral microbiology.

[12]  J. Meurman,et al.  Treponema denticola associates with increased levels of MMP-8 and MMP-9 in gingival crevicular fluid. , 2013, Oral diseases.

[13]  D. Michaud.  Role of bacterial infections in pancreatic cancer. , 2013, Carcinogenesis.

[14]  M. R. Rubinstein,et al.  Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. , 2013, Cell host & microbe.

[15]  Kehu Yang,et al.  Clinicopathological and prognostic role of MMP-9 in esophageal squamous cell carcinoma: a meta-analysis. , 2013, Chinese journal of cancer research = Chung-kuo yen cheng yen chiu.

[16]  F. Clavel-Chapelon,et al.  Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study , 2012, Gut.

[17]  R. Hayes,et al.  Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality. , 2012, Carcinogenesis.

[18]  D. Dymock,et al.  Treponema denticola chymotrypsin-like proteinase (CTLP) integrates spirochaetes within oral microbial communities. , 2012, Microbiology.

[19]  R. Hayes,et al.  Oral microbiome and oral and gastrointestinal cancer risk , 2012, Cancer Causes & Control.

[20]  J. Fenno.  Treponema denticola interactions with host proteins , 2012, Journal of oral microbiology.

[21]  E. Domann,et al.  B7-H1 and B7-DC receptors of oral squamous carcinoma cells are upregulated by Porphyromonas gingivalis. , 2011, Immunobiology.

[22]  C. Seers,et al.  Virulence Factors of the Oral Spirochete Treponema denticola , 2011, Journal of dental research.

[23]  Z. Werb,et al.  Matrix Metalloproteinases: Regulators of the Tumor Microenvironment , 2010, Cell.

[24]  X. Puente,et al.  Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion. , 2008, Cancer research.

[25]  C. López-Otín,et al.  Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer , 2008, British Journal of Cancer.

[26]  J. Gu,et al.  Matrix metalloproteinase polymorphisms and bladder cancer risk. , 2006, Cancer research.

[27]  D. Parkin,et al.  The global health burden of infection‐associated cancers in the year 2002 , 2006, International journal of cancer.

[28]  Kevin R Coombes,et al.  Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteins. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[29]  Y. Tachimori,et al.  Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers , 2004, Cancer science.

[30]  Zhifu Sun,et al.  Role of imbalance between neutrophil elastase and alpha 1-antitrypsin in cancer development and progression. , 2004, The Lancet. Oncology.

[31]  H. Moch,et al.  Cytokine-regulated expression of collagenase-2 (MMP-8) is involved in the progression of ovarian cancer. , 2003, European journal of cancer.

[32]  H. Lee,et al.  Induction of Osteoclastogenesis and Matrix Metalloproteinase Expression by the Lipooligosaccharide of Treponema denticola , 2003, Infection and Immunity.

[33]  T. Salo,et al.  Expression and regulation of collagenase‐2 (MMP‐8) in head and neck squamous cell carcinomas , 2002, The Journal of pathology.

[34]  I. Goldberg,et al.  Complex roles of tissue inhibitors of metalloproteinases in cancer , 2002, Oncogene.

[35]  H. Newman,et al.  The microflora associated with human oral carcinomas. , 1998, Oral oncology.

[36]  U. Bergmann,et al.  Activation of Type IV Procollagenases by Human Tumor-associated Trypsin-2* , 1997, The Journal of Biological Chemistry.

[37]  T. Salo,et al.  Membrane Components of Treponema denticola Trigger Proteinase Release from Human Polymorphonuclear Leukocytes , 1996, Journal of dental research.

[38]  B. Finlay,et al.  Cytopathic effects of Treponema denticola chymotrypsin-like proteinase on migrating and stratified epithelial cells , 1995, Infection and immunity.

[39]  Y. Konttinen,et al.  Identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases , 1992, Infection and immunity.

[40]  H. Itoh,et al.  Prognostic significance of alpha‐1‐antitrypsin in early stage of colorectal carcinomas , 1990, International journal of cancer.

[41]  V. Uitto,et al.  Cellular location of a Treponema denticola chymotrypsinlike protease and importance of the protease in migration through the basement membrane , 1990, Infection and immunity.

[42]  T. Sorsa,et al.  Comparison of interstitial collagenases from human gingiva, sulcular fluid and polymorphonuclear leukocytes. , 1988, Journal of periodontal research.

[43]  V. Uitto,et al.  Isolation of a chymotrypsinlike enzyme from Treponema denticola , 1988, Infection and immunity.

[44]  K. Hasty,et al.  The collagen substrate specificity of human neutrophil collagenase. , 1987, The Journal of biological chemistry.

[45]  C. Kittas,et al.  Immunocytochemical demonstration of a1-Antitrypsin and a1-Antichymotrypsin in human gastrointestinal tract. , 1982, Hepato-gastroenterology.

[46]  S. Fitzpatrick,et al.  The association between periodontal disease and cancer: a review of the literature. , 2010, Journal of dentistry.

[47]  K. Brew,et al.  The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. , 2010, Biochimica et biophysica acta.

[48]  V. Sambri,et al.  Molecular detection of Treponema denticola and Porphyromonas gingivalis in carotid and aortic atheromatous plaques by FISH: report of two cases. , 2005, Journal of medical microbiology.

[49]  H. Allgayer,et al.  Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns , 2004, Clinical & Experimental Metastasis.