Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation.

[1]  G. Pagès,et al.  Molecular Mechanisms of Resistance to Tumour Anti-Angiogenic Strategies , 2010, Journal of oncology.

[2]  M. Waring Lipophilicity in drug discovery , 2010, Expert opinion on drug discovery.

[3]  R. Kalluri,et al.  Drug resistance associated with antiangiogenesis therapy. , 2009, Seminars in cancer biology.

[4]  Helen X. Chen,et al.  Adverse effects of anticancer agents that target the VEGF pathway , 2009, Nature Reviews Clinical Oncology.

[5]  D. Hanahan,et al.  Modes of resistance to anti-angiogenic therapy , 2008, Nature Reviews Cancer.

[6]  R. A. Etten,et al.  Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition , 2007, Nature Reviews Cancer.

[7]  Minhong Yan,et al.  Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis , 2006, Nature.

[8]  S. Wilhelm,et al.  Discovery and development of sorafenib: a multikinase inhibitor for treating cancer , 2006, Nature Reviews Drug Discovery.

[9]  Sung-Yu Hong,et al.  Synthesis and biological evaluation of 5-arylamino-1H-benzo[d]imidazole-4,7-diones as inhibitor of endothelial cell proliferation. , 2006, Bioorganic & medicinal chemistry.

[10]  S. Kuromitsu,et al.  YM-201627: an orally active antitumor agent with selective inhibition of vascular endothelial cell proliferation. , 2006, Cancer letters.

[11]  Paolo Valerio,et al.  Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: from the biology to the clinic. , 2006, Current medicinal chemistry.

[12]  M. Shibuya,et al.  Bastadin 6, a spongean brominated tyrosine derivative, inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells , 2006, Anti-cancer drugs.

[13]  Yasuo Watanabe,et al.  Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex. , 2006, Journal of the American Chemical Society.

[14]  C. Chen,et al.  Inhibition of human vascular endothelial cells proliferation by terbinafine , 2004, International journal of cancer.

[15]  J. Berlin,et al.  Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. , 2004, The New England journal of medicine.

[16]  M. Feher,et al.  Synthesis and evaluation of a novel nonsteroidal-specific endothelial cell proliferation inhibitor. , 2003, Journal of medicinal chemistry.

[17]  J. Folkman Role of angiogenesis in tumor growth and metastasis. , 2002, Seminars in oncology.

[18]  K. Umezawa,et al.  Selective growth inhibition by sangivamycin of human umbilical vein endothelial cells. , 2001, International journal of oncology.

[19]  J. Henkin,et al.  Selective inhibition of endothelial cell proliferation by fumagillin is not due to differential expression of methionine aminopeptidases , 2000, Journal of cellular biochemistry.

[20]  K. Umezawa,et al.  Induction of G1 arrest and selective growth inhibition by lactacystin in human umbilical vein endothelial cells. , 1999, Anticancer research.

[21]  R. Löbenberg,et al.  Evaluation of Various Dissolution Media for Predicting In Vivo Performance of Class I and II Drugs , 1998, Pharmaceutical Research.

[22]  A. Mantovani,et al.  Molecular mechanisms of blood vessel formation. , 1997, Trends in biochemical sciences.

[23]  A. Wagner,et al.  Conversion of Primary Amides to Nitriles by Aldehyde-Catalyzed Water Transfer. , 1996, The Journal of organic chemistry.

[24]  D. Ingber,et al.  Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470). , 1994, British Journal of Cancer.

[25]  S. Iyer,et al.  Regiospecific synthesis of 2-methoxy-3-methyl-1,4-benzoquinones from maleoylcobalt complexes and alkynes via Lewis acid catalysis. A highly convergent route to isoquinoline quinones , 1987 .

[26]  Denys N. Wheatley,et al.  An in vitro model of angiogenesis: Basic features , 2004, Angiogenesis.

[27]  J. Møller,et al.  CONVENIENT METHOD FOR THE ORTHO-FORMYLATION OF PHENOLS , 1999 .

[28]  P. Molina,et al.  An Efficient One-Pot Synthesis of Pyrrolo[4,3,2-ij]isoquinoline Derivatives by a Consecutive Aza-Wittig/Electrocyclic Ring-Closure/Intramolecular Acylation Process , 1992 .

[29]  W. Childers,et al.  Oxidation of α,β-un saturated aldehydes , 1981 .