Tribological Study on New Therapeutic Bionic Lubricants

New therapeutic bionic lubricants for artificial joint lubrication and the treatment of particle-induced osteolysis were developed. In this study, their tribological characteristics and mechanisms have been investigated. The tribological experimental results show that the therapeutic lubricants have the best anti-wear performance among the lubricants tested, such as hyaluronic acid (HA) and bovine serum. Some self-assembled membranes were found on the surfaces of the cups, which might contribute to the high lubrication performance of the therapeutic lubricants. The calculated film thickness of therapeutic lubricants is about 0.310 μm, which is still in the boundary lubrication region. The preliminary biological experiments show that therapeutic lubricants have good biocompatibility. It is necessary to do more experimental work in the future to investigate the formation of the membrane and the medical performance of the therapeutic bionic lubricants for better understanding of the effects of the undesired reactions induced by the wear debris.

[1]  V. Saikko,et al.  Effect of counterface roughness on the wear of conventional and crosslinked ultrahigh molecular weight polyethylene studied with a multi-directional motion pin-on-disk device. , 2001, Journal of biomedical materials research.

[2]  A Seireg,et al.  The prediction of muscular lad sharing and joint forces in the lower extremities during walking. , 1975, Journal of biomechanics.

[3]  T. Band,et al.  A tribological study of cobalt chromium molybdenum alloys used in metal-on-metal resurfacing hip arthroplasty , 2003 .

[4]  H. Moes,et al.  Film thickness in elastohydrodynamically lubricated elliptic contacts , 1994 .

[5]  V. Mow,et al.  Constituents and pH changes in protein rich hyaluronan solution affect the biotribological properties of artificial articular joints. , 2001, Journal of biomechanics.

[6]  J. Fisher,et al.  Long-term wear of ceramic matrix composite materials for hip prostheses under severe swing phase microseparation. , 2003, Journal of biomedical materials research. Part B, Applied biomaterials.

[7]  J. Jurvelin,et al.  Alendronate Reduces Periprosthetic Bone Loss After Uncemented Primary Total Hip Arthroplasty: A Prospective Randomized Study , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[8]  P. Millett,et al.  Effects of Alendronate on Particle-Induced Osteolysis in a Rat Model , 2002, The Journal of bone and joint surgery. American volume.

[9]  T. Yamaguchi,et al.  Molecular weight independence of the effect of additive hyaluronic acid on the lubricating characteristics in synovial joints with experimental deterioration. , 1999, Clinical biomechanics.

[10]  Yoshinori Sawae,et al.  Effect of synovia constituents on friction and wear of ultra-high molecular weight polyethylene sliding against prosthetic joint materials , 1998 .

[11]  W. Harris,et al.  The problem is osteolysis. , 1995, Clinical orthopaedics and related research.

[12]  Bing Shi,et al.  Applications of plasma coatings in artificial joints: an overview , 2004 .

[13]  B. Božič,et al.  The Basis of the Synovial Fluid Analysis , 2001, Clinical chemistry and laboratory medicine.

[14]  A Sarmiento,et al.  The origin of submicron polyethylene wear debris in total hip arthroplasty. , 1995, Clinical orthopaedics and related research.

[15]  A. Wang,et al.  The effects of lubricant composition on in vitro wear testing of polymeric acetabular components. , 2004, Journal of biomedical materials research. Part B, Applied biomaterials.

[16]  G Lewis,et al.  Polyethylene wear in total hip and knee arthroplasties. , 1997, Journal of biomedical materials research.

[17]  H. Rubash,et al.  The John Charnley Award. Inhibition of wear debris mediated osteolysis in a canine total hip arthroplasty model. , 1997, Clinical orthopaedics and related research.

[18]  V. Saikko,et al.  Wear of prosthetic joint materials in various lubricants , 1997 .

[19]  Tao De-hua Tester for Bio-Artificial-Joints and Experimental Study , 2006 .

[20]  D. Jerrard,et al.  Synovial fluid analysis. , 2006, The Journal of emergency medicine.

[21]  Vesa Saikko,et al.  Effect of Lubricant Protein Concentration on the Wear of Ultra-High Molecular Weight Polyethylene Sliding Against a CoCr Counterface , 2003 .

[22]  J. Eisman,et al.  Transient Retention of Endochondral Cartilaginous Matrix With Bisphosphonate Treatment in a Long‐Term Rabbit Model of Distraction Osteogenesis , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  Jianhua Zhang,et al.  Design and mechanics simulation of bionic lubrication system of artificial joints , 2006 .

[24]  H. Rubash,et al.  Osteoblast proliferation and maturation by bisphosphonates. , 2004, Biomaterials.

[25]  Z. Jin,et al.  Elastohydrodynamic Lubrication Modeling of Artificial Hip Joints Under Steady-State Conditions , 2005 .

[26]  G. Fenske,et al.  Tribological performance of some alternative bearing materials for artificial joints , 2003 .

[27]  Roy D. Crowninshield,et al.  The influences of lubricant and material on polymer/CoCr sliding friction , 2003 .

[28]  Zhang Jian Design of Bionic Lubrication System of Artificial Joints and Study on the Tribological Performance of a Synthetic Synovial Fluid , 2003 .

[29]  M J Pearcy,et al.  The role of polyethylene wear in joint replacement failure , 1997, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[30]  J. Vörös,et al.  Influence of polymer surface chemistry on frictional properties under protein-lubrication conditions: implications for hip-implant design , 2001 .

[31]  I C Clarke,et al.  Mechanism and clinical significance of wear debris-induced osteolysis. , 1992, Clinical orthopaedics and related research.

[32]  G. Gao,et al.  A molecular-thermodynamic model for the interactions between globular proteins in aqueous solutions: applications to bovine serum albumin (BSA), lysozyme, alpha-chymotrypsin, and immuno-gamma-globulins (IgG) solutions. , 2006, Journal of colloid and interface science.

[33]  D. Dowson,et al.  Prediction of lubricating film thickness in UHMWPE hip joint replacements. , 2001, Journal of biomechanics.

[34]  J. Prausnitz,et al.  Thermodynamic properties of aqueous .alpha.-chymotrypsin solution from membrane osmometry measurements , 1992 .

[35]  Paul R. Williams,et al.  Zoledronic Acid Prevents Osteopenia and Increases Bone Strength in a Rabbit Model of Distraction Osteogenesis , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[36]  Kevin J Deluzio,et al.  Knee and hip kinetics during normal stair climbing. , 2002, Gait & posture.