Effect of flavonoids on bond strength of dentin adhesives

The effectiveness of adhesive restorations depends on a durable long-term dentin bond. Due to collagen fibril denaturation, the consistency and durability of bonding to caries-affected dentin can be questioned as compared to sound dentin. Exogenous cross-linking agents have been suggested as a viable method of inhibiting MMP activity and retaining collagen within the dentin-bonded interface. Due to their strong antioxidant capacity, flavonoids are natural cross linkers that play an important role in protecting unprotected collagen fibrils inside the hybrid layer. This study aimed to evaluate the effectiveness of flavonoids incorporated dentin adhesives in improving the bond strength of composite resin. A search was performed in the electronic databases (PUBMED CENTRAL, Medline, Scopus, Lilacs, Science Direct, Google scholar and Hand Search) using search terms alone and in combination by means of PUBMED search builder upto March 2021. Also cross check of  reference was done on all potentially eligible articles. Initially 47 articles were identified.2 articles were removed because of duplicates. After title and abstract screening 27 articles were removed.After reading full texts,4 articles were removed and finally 14 articles were included in this review for detailed analysis.

[1]  L. Breschi,et al.  Dentin Cross-linking Effect of Carbodiimide After 5 Years , 2021, Journal of dental research.

[2]  J. D. de Freitas,et al.  Polyphenols and Brazilian red propolis incorporated into a total-etching adhesive system help in maintaining bonding durability , 2021, Heliyon.

[3]  N. Ilie,et al.  Antioxidants and Collagen-Crosslinking: Benefit on Bond Strength and Clinical Applicability , 2020, Materials.

[4]  C. Turssi,et al.  Polyphenol-enriched extract of Arrabidaea chica used as a dentin pretreatment or incorporated into a total-etching adhesive system: Effects on bonding stability and physical characterization. , 2020, Materials science & engineering. C, Materials for biological applications.

[5]  C. César,et al.  Comparison of morphological changes of corneal collagen fibers treated with collagen crosslinking agents using second harmonic generation images. , 2020, International journal of biological macromolecules.

[6]  Abdul Latif Khan,et al.  Application of natural crosslinkers on tooth surface: an in-vitro comparative evaluation of resin-dentin bond strength. , 2020, JPMA. The Journal of the Pakistan Medical Association.

[7]  Chaoyang Wang,et al.  A novel prime-&-rinse mode using MDP and MMPs inhibitors improves the dentin bond durability of self-etch adhesive. , 2020, Journal of the mechanical behavior of biomedical materials.

[8]  J. Perdigão,et al.  Two-year clinical evaluation of proanthocyanidins added to a two-step etch-and-rinse adhesive. , 2019, Journal of dentistry.

[9]  Sayed Ghorab,et al.  Effect of hesperidin on antibacterial activity and adhesive properti es of an etch-and-rinse adhesive system , 2018, Egyptian Dental Journal.

[10]  S. L. Santiago,et al.  Dentin bonding and physicochemical properties of adhesives incorporated with epigallocatechin-3-gallate , 2018, Odontology.

[11]  R. Yunes,et al.  Natural Products as Source of Molecules with Therapeutic Potential: Research & Development, Challenges and Perspectives , 2018 .

[12]  V. Miletic.  Dental Composite Materials for Direct Restorations , 2018, Springer International Publishing.

[13]  Quanli Li,et al.  Anti-proteolytic property and bonding durability of mussel adhesive protein-modified dentin adhesive interface. , 2017, Dental materials : official publication of the Academy of Dental Materials.

[14]  Huiyi Yan,et al.  High-performance therapeutic quercetin-doped adhesive for adhesive–dentin interfaces , 2017, Scientific Reports.

[15]  Jihua Chen,et al.  Epigallocatechin-3-gallate and Epigallocatechin-3-O-(3-O-methyl)-gallate Enhance the Bonding Stability of an Etch-and-Rinse Adhesive to Dentin , 2017, Materials.

[16]  A. Reis,et al.  Effect of six month storage on microtensile bond strength of new elective etching adhesive system on dentin in self-etching or etch-and-rinse approach , 2017 .

[17]  F. Apollonio,et al.  Use of crosslinkers to inactivate dentin MMPs. , 2016, Dental materials : official publication of the Academy of Dental Materials.

[18]  Erik Kaestner,et al.  Collagen Primer In Structure Processing And Assembly , 2016 .

[19]  M. Burrow,et al.  Effect of proanthocyanidin incorporation into dental adhesive on durability of resin–dentin bond , 2015 .

[20]  Z. A. Bhat,et al.  Blessings in disguise: Bio-functional benefits of grape seed extracts , 2015 .

[21]  T. Watson,et al.  An MMP-inhibitor modified adhesive primer enhances bond durability to carious dentin. , 2015, Dental materials : official publication of the Academy of Dental Materials.

[22]  L. Correr-Sobrinho,et al.  Effect of antioxidants on the dentin interface bond stability of adhesives exposed to hydrolytic degradation. , 2015, The journal of adhesive dentistry.

[23]  R. França,et al.  Effect of natural polyphenols on resin–dentin bond strength , 2015 .

[24]  M. Virdi.  Emerging Trends In Oral Health Sciences And Dentistry , 2015 .

[25]  Md. Sofiqul Islam,et al.  Effect of hesperidin incorporation into a self-etching primer on durability of dentin bond. , 2014, Dental materials : official publication of the Academy of Dental Materials.

[26]  J. Napolitano,et al.  Galloyl moieties enhance the dentin biomodification potential of plant-derived catechins. , 2014, Acta biomaterialia.

[27]  M. Otsuki,et al.  Effect of natural cross-linkers incorporation in a self-etching primer on dentine bond strength. , 2012, Journal of dentistry.

[28]  Yufeng Zhang,et al.  Epigallocatechin-3-gallate (EGCG) enhances the therapeutic activity of a dental adhesive. , 2012, Journal of dentistry.

[29]  R. Frankenberger,et al.  Influence of preliminary etching on the stability of bonds created by one-step self-etch bonding systems. , 2012, European journal of oral sciences.

[30]  T. Watson,et al.  Effects of MMP Inhibitors Incorporated within Dental Adhesives , 2012, Journal of dental research.

[31]  M. Burrow,et al.  Effect of proanthocyanidin incorporation into dental adhesive resin on resin-dentine bond strength. , 2012, Journal of dentistry.

[32]  Shun-Fa Yang,et al.  Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator. , 2007, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[33]  S. Mun,et al.  Characterization of proanthocyanidin in hot water extract isolated from Pinus radiata bark , 2007, Wood Science and Technology.

[34]  Seong-Ho Choi,et al.  Inhibitory effects of green tea polyphenol (-)-epigallocatechin gallate on the expression of matrix metalloproteinase-9 and on the formation of osteoclasts. , 2004, Journal of periodontal research.

[35]  P. Vallittu.  Bonding of hybrid composite resin to the surface of gold-alloy used in porcelain-fused-to-metal restorations. , 1997, Journal of oral rehabilitation.

[36]  S. S. Negi.  Wood science and technology. , 1997 .

[37]  G. Laurent,et al.  Collagen synthesis and degradation in vivo. Evidence for rapid rates of collagen turnover with extensive degradation of newly synthesized collagen in tissues of the adult rat. , 1987, Collagen and related research.

[38]  Subcourse.  Dental materials. , 1977, British dental journal.

[39]  D. Retief.  Adhesion in biological systems. , 1975, The Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika.

[40]  D. L. Venezky.  Adhesive Restorative Dental Materials. A Literature Survey of Inorganic Polymers , 1965 .

[41]  Platelet-rich fibrin: Its role in periodontal regeneration The Saudi Journal for Dental Research , 2022 .