Homocysteine May Decrease Glucose Uptake and Alter the Akt/GSK3β/GLUT1 Signaling Pathway in Hippocampal Slices: Neuroprotective Effects of Rivastigmine and Ibuprofen

[1]  C. Vargas,et al.  High-protein nutrition during pregnancy increases neuroinflammation and homocysteine levels and impairs behavior in male adolescent rats offspring. , 2022, Life sciences.

[2]  Lijuan Zhang,et al.  Diagnostic Values of Advanced Glycation End Products and Homocysteine in Patients with Alzheimer's Disease and Sarcopenia , 2022, Computational and mathematical methods in medicine.

[3]  S. Sadigh-Eteghad,et al.  Pharmacotherapy of Alzheimer’s disease: an overview of systematic reviews , 2022, European Journal of Clinical Pharmacology.

[4]  A. S. Kazakov,et al.  Ibuprofen Favors Binding of Amyloid-β Peptide to Its Depot, Serum Albumin , 2022, International journal of molecular sciences.

[5]  A. Wyse,et al.  Rivastigmine Reverses the Decrease in Synapsin and Memory Caused by Homocysteine: Is There Relation to Inflammation? , 2022, Molecular Neurobiology.

[6]  Navid Abedpoor,et al.  Cross Brain–Gut Analysis Highlighted Hub Genes and LncRNA Networks Differentially Modified During Leucine Consumption and Endurance Exercise in Mice with Depression-Like Behaviors , 2022, Molecular Neurobiology.

[7]  A. Wyse,et al.  Quinolinic Acid Impairs Redox Homeostasis, Bioenergetic, and Cell Signaling in Rat Striatum Slices: Prevention by Coenzyme Q10 , 2022, Neurotoxicity Research.

[8]  D. Holtzman,et al.  Astrocytic α2-Na+/K+ ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model , 2022, Science Translational Medicine.

[9]  C. Watala,et al.  Melatonin as a Reducer of Neuro- and Vasculotoxic Oxidative Stress Induced by Homocysteine , 2021, Antioxidants.

[10]  M. Mattson,et al.  Glucose metabolic crosstalk and regulation in brain function and diseases , 2021, Progress in Neurobiology.

[11]  Liyi Xie,et al.  Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation. , 2021, Biochemical and biophysical research communications.

[12]  M. Bishnoi,et al.  Sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of Alzheimer’s disease through modulation of brain insulin resistance induced tau pathology , 2020, Brain Research Bulletin.

[13]  L. Banci,et al.  Methylglyoxal interaction with superoxide dismutase 1 , 2020, Redox biology.

[14]  M. Bishnoi,et al.  Chromium picolinate attenuates cognitive deficit in ICV-STZ rat paradigm of sporadic Alzheimer’s-like dementia via targeting neuroinflammatory and IRS-1/PI3K/AKT/GSK-3β pathway , 2020, Inflammopharmacology.

[15]  A. Wyse,et al.  Chronic mild hyperhomocysteinemia induces anxiety-like symptoms, aversive memory deficits and hippocampus atrophy in adult rats: New insights into physiopathological mechanisms , 2019, Brain Research.

[16]  M. Chang,et al.  Didymin, a dietary citrus flavonoid exhibits anti-diabetic complications and promotes glucose uptake through the activation of PI3K/Akt signaling pathway in insulin-resistant HepG2 cells. , 2019, Chemico-biological interactions.

[17]  A. Wyse,et al.  Chronic mild Hyperhomocysteinemia impairs energy metabolism, promotes DNA damage and induces a Nrf2 response to oxidative stress in rats brain , 2019, Cellular and Molecular Neurobiology.

[18]  D. Butterfield,et al.  Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease , 2019, Nature Reviews Neuroscience.

[19]  C. Gonçalves,et al.  GABAA Modulation of S100B Secretion in Acute Hippocampal Slices and Astrocyte Cultures , 2018, Neurochemical Research.

[20]  P. Moreira,et al.  Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease , 2018, Neuropharmacology.

[21]  Virginia Gao,et al.  Astrocyte glycogen and lactate: New insights into learning and memory mechanisms , 2018, Glia.

[22]  M. Gemma,et al.  Regional Differences in Cerebral Glucose Metabolism After Cardiac Arrest and Resuscitation in Rats Using [18F]FDG Positron Emission Tomography and Autoradiography , 2018, Neurocritical Care.

[23]  Helena Biasibetti-Brendler,et al.  Kynurenic Acid Restores Nrf2 Levels and Prevents Quinolinic Acid-Induced Toxicity in Rat Striatal Slices , 2018, Molecular Neurobiology.

[24]  L. Bobermin,et al.  Homocysteine Induces Glial Reactivity in Adult Rat Astrocyte Cultures , 2017, Molecular Neurobiology.

[25]  Yi Fu,et al.  Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury , 2018, Nature Communications.

[26]  Xiao-Liang Liu,et al.  Mitochondria-mediated damage to dopaminergic neurons in Parkinson's disease (Review). , 2017, International journal of molecular medicine.

[27]  Bin Wang,et al.  N-acetylcysteine attenuates systemic platelet activation and cerebral vessel thrombosis in diabetes , 2017, Redox biology.

[28]  Guowei Huang,et al.  Homocysteine induces mitochondrial dysfunction involving the crosstalk between oxidative stress and mitochondrial pSTAT3 in rat ischemic brain , 2017, Scientific Reports.

[29]  R. Fan,et al.  Association between Homocysteine Levels and All-cause Mortality: A Dose-Response Meta-Analysis of Prospective Studies , 2017, Scientific Reports.

[30]  M. Franco,et al.  Cellular mechanisms of peroxynitrite-induced neuronal death , 2017, Brain Research Bulletin.

[31]  M. Mattson,et al.  Brain metabolism in health, aging, and neurodegeneration , 2017, The EMBO journal.

[32]  F. Treulén,et al.  Nitrosative stress by peroxynitrite impairs ATP production in human spermatozoa , 2017, Andrologia.

[33]  H. Jakubowski Homocysteine Editing, Thioester Chemistry, Coenzyme A, and the Origin of Coded Peptide Synthesis † , 2017, Life.

[34]  Anupom Borah,et al.  Oxidative stress and mitochondrial dysfunction are the underlying events of dopaminergic neurodegeneration in homocysteine rat model of Parkinson's disease , 2016, Neurochemistry International.

[35]  M. Hackett,et al.  Concurrent Glycogen and Lactate Imaging with FTIR Spectroscopy To Spatially Localize Metabolic Parameters of the Glial Response Following Brain Ischemia. , 2016, Analytical chemistry.

[36]  M. Brimble,et al.  Chemical Synthesis of Peptides Containing Site-Specific Advanced Glycation Endproducts. , 2016, Accounts of chemical research.

[37]  H. Heller,et al.  Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice. , 2016, Brain : a journal of neurology.

[38]  O. El‐Agnaf,et al.  Glycation in Parkinson's disease and Alzheimer's disease , 2016, Movement disorders : official journal of the Movement Disorder Society.

[39]  M. Maines,et al.  Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice , 2016, Journal of diabetes research.

[40]  J. Mauer,et al.  Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity , 2016, Cell.

[41]  G. Zuliani,et al.  The relationship between hyperhomocysteinemia and neurodegeneration. , 2016, Neurodegenerative disease management.

[42]  Cristina M. Alberini,et al.  The Role of Lactate-Mediated Metabolic Coupling between Astrocytes and Neurons in Long-Term Memory Formation , 2016, Front. Integr. Neurosci..

[43]  A. Tosetto,et al.  Comparison between different D‐Dimer cutoff values to assess the individual risk of recurrent venous thromboembolism: analysis of results obtained in the DULCIS study , 2016, International journal of laboratory hematology.

[44]  C. Cobb,et al.  Oxidative and nitrative stress in neurodegeneration , 2015, Neurobiology of Disease.

[45]  R. Giniatullin,et al.  Homocysteine aggravates ROS-induced depression of transmitter release from motor nerve terminals: potential mechanism of peripheral impairment in motor neuron diseases associated with hyperhomocysteinemia , 2015, Front. Cell. Neurosci..

[46]  Li Ren,et al.  Long-term effectiveness of rivastigmine patch or capsule for mild-to-severe Alzheimer’s disease: a meta-analysis , 2015, Expert review of neurotherapeutics.

[47]  Anupom Borah,et al.  Activation of NMDA receptor by elevated homocysteine in chronic liver disease contributes to encephalopathy. , 2015, Medical hypotheses.

[48]  Du-Qiang Luo,et al.  Fumosorinone, a novel PTP1B inhibitor, activates insulin signaling in insulin-resistance HepG2 cells and shows anti-diabetic effect in diabetic KKAy mice. , 2015, Toxicology and applied pharmacology.

[49]  M. Berk,et al.  The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders , 2015, BMC Medicine.

[50]  J. Ávila,et al.  Peripherally triggered and GSK-3β-driven brain inflammation differentially skew adult hippocampal neurogenesis, behavioral pattern separation and microglial activation in response to ibuprofen , 2014, Translational Psychiatry.

[51]  C. Kahn,et al.  Insulin Action in Brain Regulates Systemic Metabolism and Brain Function , 2014, Diabetes.

[52]  A. Gugliandolo,et al.  Toxic Effects of Mildly Elevated Homocysteine Concentrations in Neuronal-Like Cells , 2014, Neurochemical Research.

[53]  C. Baggio,et al.  Antidepressant and Antioxidative Effect of Ibuprofen in the Rotenone Model of Parkinson’s Disease , 2014, Neurotoxicity Research.

[54]  L. Dworkin,et al.  Redox-sensitive glycogen synthase kinase 3β-directed control of mitochondrial permeability transition: rheostatic regulation of acute kidney injury. , 2013, Free radical biology & medicine.

[55]  D. Gelain,et al.  Passiflora manicata (Juss.) aqueous leaf extract protects against reactive oxygen species and protein glycation in vitro and ex vivo models. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[56]  K. Sinha,et al.  Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis , 2013, Archives of Toxicology.

[57]  Surojit Paul,et al.  Novel crosstalk between ERK MAPK and p38 MAPK leads to homocysteine‐NMDA receptor‐mediated neuronal cell death , 2013, Journal of neurochemistry.

[58]  K. Herrup,et al.  Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease , 2012, Neurobiology of Aging.

[59]  Pierre J Magistretti,et al.  Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. , 2011, Cell metabolism.

[60]  Richard E. White,et al.  The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells. , 2011, Investigative ophthalmology & visual science.

[61]  A. Haghparast,et al.  Curcumin exerts neuroprotective effects against homocysteine intracerebroventricular injection-induced cognitive impairment and oxidative stress in rat brain. , 2010, Journal of medicinal food.

[62]  B. Jenkins,et al.  Anti-inflammatory treatment in AD mice protects against neuronal pathology , 2010, Experimental Neurology.

[63]  K. Rainsford Ibuprofen: pharmacology, efficacy and safety , 2009, Inflammopharmacology.

[64]  Surojit Paul,et al.  Homocysteine–NMDA receptor‐mediated activation of extracellular signal‐regulated kinase leads to neuronal cell death , 2009, Journal of neurochemistry.

[65]  James L. Park,et al.  A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. , 2008, American journal of physiology. Cell physiology.

[66]  Donald R. Miller,et al.  Protective effects of NSAIDs on the development of Alzheimer disease , 2008, Neurology.

[67]  J. Houštěk,et al.  Mitochondrial complex I inhibition in cerebral cortex of immature rats following homocysteic acid-induced seizures , 2007, Experimental Neurology.

[68]  Bin Zhang,et al.  Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model , 2007, Neuron.

[69]  R. Obeid,et al.  Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia , 2006, FEBS letters.

[70]  A. Boldyrev Homocysteinic Acid Causes Oxidative Stress in Lymphocytes by Potentiating Toxic Effect of NMDA , 2005, Bulletin of Experimental Biology and Medicine.

[71]  V. Sánchez-Margalet,et al.  Homocysteine thiolactone inhibits insulin-stimulated DNA and protein synthesis: possible role of mitogen-activated protein kinase (MAPK), glycogen synthase kinase-3 (GSK-3) and p70 S6K phosphorylation. , 2005, Journal of molecular endocrinology.

[72]  V. Sánchez-Margalet,et al.  Homocysteine thiolactone inhibits insulin signaling, and glutathione has a protective effect. , 2001, Journal of molecular endocrinology.

[73]  D. Ashline,et al.  Homocysteine potentiates β‐amyloid neurotoxicity: role of oxidative stress , 2001 .

[74]  D. Peterson,et al.  Mechanism of Cellular 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction , 1997, Journal of neurochemistry.

[75]  P. Magistretti,et al.  Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[76]  L. Ignarro,et al.  Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[77]  H. Ischiropoulos,et al.  Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. , 1992, Chemical research in toxicology.

[78]  K. Chan,et al.  A direct colorimetric assay for Ca2+ -stimulated ATPase activity. , 1986, Analytical biochemistry.

[79]  G. Dienel Brain Glucose Metabolism: Integration of Energetics with Function. , 2019, Physiological reviews.

[80]  D. Dobrota,et al.  Effects of mild hyperhomocysteinemia on electron transport chain complexes, oxidative stress, and protein expression in rat cardiac mitochondria , 2015, Molecular and Cellular Biochemistry.