Relationship between serum sialic acid levels and eye lesions in calves with infectious bovine keratoconjunctivitis

Le but de cette etude etait d'evaluer l'importance biochimique et clinique des concentrations seriques en acide sialique des veaux atteints de keratoconjonctivite. Au cours de cette etude, nous avons utilise18 veaux atteints de keratoconjonctivite (Groupe I) et 11 veaux sains (Groupe II). Afin de determiner les concentrations seriques de glucose et d'acide sialique, des prelevements sanguins ont ete effectues chez tous les veaux.. Les lesions oculaires ont ete classees comme d'intensite faible, moyenne et elevee selon l'importance des signes cliniques. La concentration moyenne en acide sialique total (TSA), lie aux lipides (LBSA) et lie aux proteines (PBSA) des veaux atteints de keratoconjonctivite a ete respectivement de 106.9 ′3.6 mg/dl, 54.8 ′2.8 mg/dl, 52.1 ′ 3.1 mg/dl. Les valeurs correspondantes des concentrations seriques en TSA, LBSA et PBSA des veaux sains etaient respectivement de 76.4 ′ 3.1mg/dl, 38.4 ′ 2.1 mg/dl and 38.0 ′ 3.7 mg/dl. Les concentrations moyennes seriques en TSA et LBSA des veaux atteints de keratoconjonctivite ont ete statistiquement superieures aux valeurs obtenues chez les veaux sains. Les concentrations seriques en LBSA ont augmente avec l'intensite des lesions oculaires. Les concentrations moyennes seriques en LBSA ont ete respectivement de 47.5′1.8 mg/dl; 50.8′0.9 mg/dl; 66.1′6,1 mg/dl chez les veaux presentant des lesions oculaires d'intensite faible, moyenne et elevee. Les resultats de cette etude suggerent que les concentrations seriques en LBSA pourraient constituer un indicateur utile dans le pronostic des lesions inflammatoires oculaires des veaux comme les infections bovines de keratoconjonctivite.

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