Association between environmental pollutants and the FSH/AMH ratio as a marker of ovarian reserve

The ovarian function decreases with age, and various markers, such as follicle stimulating hormone, inhibin B, antral follicle count, and anti-Müllerian hormone, are used for its evaluation. Recently, exposure to various environmental pollutants in daily life has been reported as an important cause of ovarian function decline. Therefore, the present study aimed to confirm the effect of environmental pollutants on the relationship between age and decline in ovarian function. The exposure levels of 16 environmental pollutants were evaluated in women aged 26–40 years, and the AMH levels and FSH/AMH ratios were used as markers for the decline of ovarian function. The participants were divided into two groups: low-level or high-level for each environmental pollutant if their exposure level was below or above the median respectively. The slope of the decrease or increase in the AMH level and FSH/AMH ratio of each group with age was evaluated. The FSH/AMH ratio better presented the difference in the rate of change with age in each group than did AMH alone. In particular, the rate of change in the FSH/AMH ratio increased 5.2 and 3.7 times (p<0.05) in the group exposed to high levels of the volatile organic compound metabolite, trans, trans-muconic acid and the polycyclic aromatic hydrocarbons metabolite, 2-hydroxynaphthalene, respectively, than in the low-level exposure groups for those metabolites. This study confirmed that environmental pollutants influenced the rate of change in the FSH/AMH ratio with age. Further studies on larger populations are necessary in the future.

[1]  S. Richards,et al.  Endocrine-Disrupting Air Pollutants and Their Effects on the Hypothalamus-Pituitary-Gonadal Axis , 2020, International journal of molecular sciences.

[2]  E. Ha,et al.  The Association of Ovarian Reserve with Exposure to Bisphenol A and Phthalate in Reproductive-aged Women , 2020, Journal of Korean medical science.

[3]  N. Toporikova,et al.  FSH/AMH Ratio and Adipocyte Size are Linked to Ovarian Dysfunction , 2020, Endocrine research.

[4]  J. Flaws,et al.  Sanitary pads and diapers contain higher phthalate contents than those in common commercial plastic products. , 2019, Reproductive toxicology.

[5]  W. Ge,et al.  Establishment and depletion of the ovarian reserve: physiology and impact of environmental chemicals , 2019, Cellular and Molecular Life Sciences.

[6]  J. Jurewicz,et al.  Exposure to modern, widespread environmental endocrine disrupting chemicals and their effect on the reproductive potential of women: an overview of current epidemiological evidence , 2019, Human fertility.

[7]  Yen-Tsung Huang,et al.  Discordant anti-müllerian hormone (AMH) and follicle stimulating hormone (FSH) among women undergoing in vitro fertilization (IVF): which one is the better predictor for live birth? , 2018, Journal of Ovarian Research.

[8]  Yi-Xin Wang,et al.  Urinary phthalate metabolites in relation to serum anti-Müllerian hormone and inhibin B levels among women from a fertility center: a retrospective analysis , 2018, Reproductive Health.

[9]  Y. Cheung,et al.  Age-related nomograms for antral follicle count and anti-Mullerian hormone for subfertile Chinese women in Singapore , 2017, PloS one.

[10]  V. Gayrard,et al.  Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data , 2017, Environmental Health.

[11]  R. Cífková,et al.  ESHRE Guideline: management of women with premature ovarian insufficiency. , 2016, Human Reproduction.

[12]  K. Kannan,et al.  Persistent Organic Pollutants and Early Menopause in U.S. Women , 2015, PloS one.

[13]  R. Vallone,et al.  Association between intrafollicular concentration of benzene and outcome of controlled ovarian stimulation in IVF/ICSI cycles: a pilot study , 2014, Journal of Ovarian Research.

[14]  A. Mantovani,et al.  Bisphenol a and the female reproductive tract: an overview of recent laboratory evidence and epidemiological studies , 2014, Reproductive Biology and Endocrinology.

[15]  N. Macklon,et al.  Environmental and developmental origins of ovarian reserve. , 2014, Human reproduction update.

[16]  S. Harlow,et al.  Updated assays for inhibin B and AMH provide evidence for regular episodic secretion of inhibin B but not AMH in the follicular phase of the normal menstrual cycle. , 2014, Human reproduction.

[17]  P. Spritzer,et al.  Effects of endocrine disruptors in the development of the female reproductive tract. , 2014, Arquivos brasileiros de endocrinologia e metabologia.

[18]  D. Cahill,et al.  Discrepancies between Antimullerian Hormone and Follicle Stimulating Hormone in Assisted Reproduction , 2013, Obstetrics and gynecology international.

[19]  Paige L. Williams,et al.  The association of bisphenol-A urinary concentrations with antral follicle counts and other measures of ovarian reserve in women undergoing infertility treatments. , 2013, Reproductive toxicology.

[20]  Budi Wiweko,et al.  Chronological age vs biological age: an age-related normogram for antral follicle count, FSH and anti-Mullerian hormone , 2013, Journal of Assisted Reproduction and Genetics.

[21]  N. Hadlow,et al.  Variation in antimüllerian hormone concentration during the menstrual cycle may change the clinical classification of the ovarian response. , 2013, Fertility and sterility.

[22]  D. Park,et al.  AGE-RELATED DISTRIBUTION OF ANTI-MÜLLERIAN HORMONE LEVELS IN 2,879 KOREAN WOMEN WITH REGULAR MENSTRUATION , 2012 .

[23]  M. Koong,et al.  Age specific serum anti-Müllerian hormone levels in 1,298 Korean women with regular menstruation , 2011, Clinical and experimental reproductive medicine.

[24]  L. Giudice,et al.  Endocrine-disrupting chemicals: an Endocrine Society scientific statement. , 2009, Endocrine reviews.

[25]  J. Habbema,et al.  Serum antimullerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study. , 2005, Fertility and sterility.

[26]  J. Flaws,et al.  The effects of endocrine disrupting chemicals on the ovary. , 2002, Frontiers in bioscience : a journal and virtual library.

[27]  B. Fauser,et al.  Lack of correlation between maximum early follicular phase serum follicle stimulating hormone concentrations and menstrual cycle characteristics in women under the age of 35 years. , 1998, Human reproduction.

[28]  H. Burger,et al.  Age related changes in follicle stimulating hormone, luteinizing hormone, oestradiol and immunoreactive inhibin in women of reproductive age , 1992, Clinical endocrinology.

[29]  Paige L. Williams,et al.  Urinary phthalate metabolites and ovarian reserve among women seeking infertility care. , 2016, Human reproduction.

[30]  C. McCulloch,et al.  A characterization of the relationship of ovarian reserve markers with age. , 2012, Fertility and sterility.

[31]  P. Barrière,et al.  Active smoking compromises IVF outcome and affects ovarian reserve. , 2008, Reproductive biomedicine online.