Non-Hodgkin's lymphoma associated with leiomyomatosis presenting with intense pruritus.

Generalized pruritus may be a presenting and/or the only symptom of malignancy. Pruritus related to non-Hodgkin’s lymphoma (NHL) has been reported in 1–3% of patients with NHL (1). We report here a patient with intractable pruritus who was diagnosed with NHL.CASe RePORtA 41-year-old woman presented with intense itching, which had been present for 6 months. the itching was continuous and occurred at the same intensity at all times. She had used various treatments, including oral antihistamines, emollients and anti-scabies therapy, to no effect. She reported that she had night sweats accompanying the pruritus. She did not describe any weight loss and denied using any drugs. Dermatological examination revealed erythematous papules with crusts and multiple excoriations due to severe itching localized on both the trunk and the extre-mities (Fig. 1). Physical examination showed multiple enlarged lymph nodes in both her axillary and inguinal regions.A detailed laboratory examination was carried out. the results were: haemoglobin level 8.3 g/dl (normal 12–14 g/dl), lactate dehydrogenase 678 U/l (normal 125–243 U/l), carcinoma antigen 125 > 600 (normal 0–35). the following values were normal: peripheral