The emergence of high-resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena.

Consultant for MS Imaging, Discovery BA & Discovery Drug Metabolism and PK, Westfield, NJ 07090, USA “Despite the recent widespread adoption and the benefits of using UHPLC–HRMS for drug metabolism, pharmacokinetics and metabonomic studies, challenges around automated user-friendly software tools, data file comparison techniques and ultimate quantitative sensitivity similar to triple quadrupole MS remain unconquered.”

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