From good to bad: Intravital imaging of the hijack of physiological processes by cancer cells.

[1]  Michael F. Cuccarese,et al.  Quantitating drug-target engagement in single cells in vitro and in vivo. , 2017, Nature chemical biology.

[2]  Mauro J. Muraro,et al.  Identity and dynamics of mammary stem cells during branching morphogenesis , 2017, Nature.

[3]  J. Condeelis,et al.  Mechanism of early dissemination and metastasis in Her2+ mammary cancer , 2016, Nature.

[4]  J. Condeelis,et al.  Macrophage-dependent tumor cell transendothelial migration is mediated by Notch1/MenaINV-initiated invadopodium formation , 2016, Scientific Reports.

[5]  Qingming Luo,et al.  Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy , 2016, eLife.

[6]  Malgorzata Nowicka,et al.  T cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments , 2016, Nature.

[7]  Luigi Preziosi,et al.  Plasticity of Cell Migration In Vivo and In Silico. , 2016, Annual review of cell and developmental biology.

[8]  Hans Clevers,et al.  Tissue-specific mutation accumulation in human adult stem cells during life , 2016, Nature.

[9]  E. Voest,et al.  Intravital characterization of tumor cell migration in pancreatic cancer , 2016, Intravital.

[10]  G. Dharmadhikari,et al.  Sequential intravital imaging reveals in vivo dynamics of pancreatic tissue transplanted under the kidney capsule in mice , 2016, Diabetologia.

[11]  J. Vincent,et al.  Exosomes in developmental signalling , 2016, Development.

[12]  J. Robert.  Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread , 2016 .

[13]  P. Kubes,et al.  A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair , 2016, Cell.

[14]  J. van Rheenen,et al.  Implications of Extracellular Vesicle Transfer on Cellular Heterogeneity in Cancer: What Are the Potential Clinical Ramifications? , 2016, Cancer research.

[15]  J. van Rheenen,et al.  Intravital Insights into Heterogeneity, Metastasis, and Therapy Responses. , 2016, Trends in cancer.

[16]  A. van Oudenaarden,et al.  Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity , 2016, Cell reports.

[17]  J. Lippincott-Schwartz,et al.  Intravital Imaging Reveals Ghost Fibers as Architectural Units Guiding Myogenic Progenitors during Regeneration. , 2016, Cell stem cell.

[18]  Erik Sahai,et al.  Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization , 2015, Cell reports.

[19]  A. Zannettino,et al.  Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche , 2015, Nature Communications.

[20]  Adelaide I J Young,et al.  ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells , 2015, PLoS biology.

[21]  Stephen T. C. Wong,et al.  EMT is not required for lung metastasis but contributes to chemoresistance , 2015, Nature.

[22]  O. Garaschuk,et al.  Brain tumour cells interconnect to a functional and resistant network , 2015, Nature.

[23]  Yarong Wang,et al.  Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA. , 2015, Cancer discovery.

[24]  D. Hume,et al.  Immune surveillance of the lung by migrating tissue monocytes , 2015, eLife.

[25]  B. Liu,et al.  Biocompatible Green and Red Fluorescent Organic Dots with Remarkably Large Two-Photon Action Cross Sections for Targeted Cellular Imaging and Real-Time Intravital Blood Vascular Visualization. , 2015, ACS applied materials & interfaces.

[26]  M. Spitaler,et al.  Automated Identification and Localization of Hematopoietic Stem Cells in 3D Intravital Microscopy Data , 2015, Stem cell reports.

[27]  P. Friedl,et al.  Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb , 2015, Proceedings of the National Academy of Sciences.

[28]  Jacco van Rheenen,et al.  In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior , 2015, Cell.

[29]  Ralph Weissleder,et al.  Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters , 2015, Nature Communications.

[30]  A. Waisman,et al.  Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes , 2015, Nature Methods.

[31]  M. Detmar,et al.  Intravital and Whole-Organ Imaging Reveals Capture of Melanoma-Derived Antigen by Lymph Node Subcapsular Macrophages Leading to Widespread Deposition on Follicular Dendritic Cells , 2015, Front. Immunol..

[32]  K. Blagoev,et al.  Niche induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool , 2015, Nature.

[33]  L. Reymond,et al.  Genetic targeting of chemical indicators in vivo , 2014, Nature Methods.

[34]  K. Khosrotehrani,et al.  Correction: In Vivo Imaging Reveals a Pioneer Wave of Monocyte Recruitment into Mouse Skin Wounds , 2014, PLoS ONE.

[35]  Z. Werb,et al.  Remodelling the extracellular matrix in development and disease , 2014, Nature Reviews Molecular Cell Biology.

[36]  Z. Werb,et al.  Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations , 2014, Proceedings of the National Academy of Sciences.

[37]  Bojana Gligorijevic,et al.  Multiparametric Classification Links Tumor Microenvironments with Tumor Cell Phenotype , 2014, PLoS biology.

[38]  K. Khosrotehrani,et al.  In Vivo Imaging Reveals a Pioneer Wave of Monocyte Recruitment into Mouse Skin Wounds , 2014, PloS one.

[39]  Amy E. Robertson,et al.  Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis. , 2014, Cell reports.

[40]  A. Miyawaki,et al.  Tracking and quantification of dendritic cell migration and antigen trafficking between the skin and lymph nodes , 2014, Scientific Reports.

[41]  I. Roeder,et al.  In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells. , 2014, Blood.

[42]  Jacco van Rheenen,et al.  Imaging hallmarks of cancer in living mice , 2014, Nature Reviews Cancer.

[43]  H. Enomoto,et al.  Mouse Spermatogenic Stem Cells Continually Interconvert between Equipotent Singly Isolated and Syncytial States , 2014, Cell stem cell.

[44]  Ralph Weissleder,et al.  Imaging windows for long-term intravital imaging , 2014, Intravital.

[45]  Max Nobis,et al.  The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues , 2014, Cell reports.

[46]  Hans Clevers,et al.  Intestinal crypt homeostasis revealed at single stem cell level by in vivo live-imaging , 2014, Nature.

[47]  H. Clevers,et al.  Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion , 2013, EMBO reports.

[48]  Andrea Sottoriva,et al.  Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation , 2013, Science.

[49]  Panteleimon Rompolas,et al.  Spatial organization within a niche as a determinant of stem cell fate , 2013, Nature.

[50]  J. van Rheenen,et al.  In vivo imaging and histochemistry are combined in the cryosection labelling and intravital microscopy technique , 2013, Nature Communications.

[51]  Neil O Carragher,et al.  Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer. , 2013, Cancer research.

[52]  Paul A. Bates,et al.  Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions , 2013, Nature Cell Biology.

[53]  D. Sipkins,et al.  LYMPHOID NEOPLASIA Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy , 2013 .

[54]  Yoshiki Miyachi,et al.  Intravital analysis of vascular permeability in mice using two-photon microscopy , 2013, Scientific Reports.

[55]  Bastian R. Angermann,et al.  Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo , 2013, Nature.

[56]  M. Clarke,et al.  Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors , 2013, Intravital.

[57]  Robert P. Jenkins,et al.  Intravital imaging reveals conversion between distinct tumor vascular morphologies and localized vascular response to Sunitinib , 2013 .

[58]  J. van Rheenen,et al.  Brief Report: Intravital Imaging of Cancer Stem Cell Plasticity in Mammary Tumors , 2012, Stem cells.

[59]  R. Jain,et al.  Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases , 2012, Proceedings of the National Academy of Sciences.

[60]  Yan Li,et al.  Quantum Dots for Cancer Research: Current Status, Remaining Issues, and Future Perspectives , 2012, Cancer biology & medicine.

[61]  P. Friedl,et al.  Classifying collective cancer cell invasion , 2012, Nature Cell Biology.

[62]  Panteleimon Rompolas,et al.  Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration , 2012, Nature.

[63]  P. Friedl,et al.  Intravital third harmonic generation microscopy of collective melanoma cell invasion , 2012, Intravital.

[64]  Jae-Hyun Park,et al.  Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. , 2012, Cancer cell.

[65]  Mikala Egeblad,et al.  Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. , 2012, Cancer cell.

[66]  David Piwnica-Worms,et al.  On in vivo imaging in cancer. , 2012, Cold Spring Harbor perspectives in biology.

[67]  A. Rocha,et al.  Distinct stem cells contribute to mammary gland development and maintenance , 2011, Nature.

[68]  D. Kobat,et al.  In vivo two-photon microscopy to 1.6-mm depth in mouse cortex. , 2011, Journal of biomedical optics.

[69]  M. Ducros,et al.  Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels , 2011, Nature Medicine.

[70]  D. Lauffenburger,et al.  Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer , 2011, Journal of Cell Science.

[71]  N. Gorfinkiel,et al.  Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium , 2011, Proceedings of the National Academy of Sciences.

[72]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[73]  Z. Werb,et al.  Monitoring of vital signs for long-term survival of mice under anesthesia. , 2011, Cold Spring Harbor protocols.

[74]  Z. Werb,et al.  Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy. , 2011, Cold Spring Harbor protocols.

[75]  Z. Werb,et al.  Preparation of mice for long-term intravital imaging of the mammary gland. , 2011, Cold Spring Harbor protocols.

[76]  Ralph Weissleder,et al.  In vivo imaging in cancer. , 2010, Cold Spring Harbor perspectives in biology.

[77]  P. Bousso,et al.  Intravital imaging reveals distinct dynamics for natural killer and CD8(+) T cells during tumor regression. , 2010, Immunity.

[78]  P. Kubes,et al.  Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation , 2010, Science.

[79]  H. Clevers,et al.  Stem cells and cancer of the stomach and intestine , 2010, Molecular oncology.

[80]  Dai Fukumura,et al.  Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in tumor vascular networks , 2010, Nature Methods.

[81]  R. Braun,et al.  Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment , 2010, Science.

[82]  Dai Fukumura,et al.  Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre‐Clinical Models , 2010, Microcirculation.

[83]  J. Spatz,et al.  Adaptive force transmission in amoeboid cell migration , 2009, Nature Cell Biology.

[84]  Erik Sahai,et al.  Localised and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility , 2009, Nature Cell Biology.

[85]  Jacco van Rheenen,et al.  Collagen-based cell migration models in vitro and in vivo. , 2009, Seminars in cell & developmental biology.

[86]  P. Lio’,et al.  Estimating Dormant and Active Hematopoietic Stem Cell Kinetics through Extensive Modeling of Bromodeoxyuridine Label-Retaining Cell Dynamics , 2009, PloS one.

[87]  Andreas Trumpp,et al.  Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair , 2008, Cell.

[88]  P. Friedl,et al.  Collective cell migration in morphogenesis, regeneration and cancer , 2009, Nature Reviews Molecular Cell Biology.

[89]  Raghu Kalluri,et al.  The basics of epithelial-mesenchymal transition. , 2009, The Journal of clinical investigation.

[90]  Rakesh K Jain,et al.  In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts , 2009, Nature Methods.

[91]  D. Lauffenburger,et al.  A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. , 2008, Developmental cell.

[92]  Jacco van Rheenen,et al.  Intravital imaging of metastatic behavior through a mammary imaging window , 2008, Nature Methods.

[93]  E. Sahai,et al.  Imaging amoeboid cancer cell motility in vivo , 2008, Journal of microscopy.

[94]  Philippe Bousso,et al.  Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice. , 2008, The Journal of clinical investigation.

[95]  D. Hume,et al.  Expression of Gal4‐dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r‐Gal4VP16/UAS‐ECFP double‐transgenic mice , 2008, Journal of leukocyte biology.

[96]  H. Clevers,et al.  Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.

[97]  R. Kalluri,et al.  Fibroblasts Derive from Hepatocytes in Liver Fibrosis via Epithelial to Mesenchymal Transition* , 2007, Journal of Biological Chemistry.

[98]  Xueli Yuan,et al.  Endothelial-to-mesenchymal transition contributes to cardiac fibrosis , 2007, Nature Medicine.

[99]  Yarong Wang,et al.  Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. , 2007, Cancer research.

[100]  Benjamin D. Simons,et al.  A single type of progenitor cell maintains normal epidermis , 2007, Nature.

[101]  Sebastian Amigorena,et al.  In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor , 2007, The Journal of experimental medicine.

[102]  D. Sheppard,et al.  Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix , 2006, Proceedings of the National Academy of Sciences.

[103]  Ralph Weissleder,et al.  Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. , 2006, Immunity.

[104]  J. Segall,et al.  The great escape: when cancer cells hijack the genes for chemotaxis and motility. , 2005, Annual review of cell and developmental biology.

[105]  N. Hirokawa,et al.  FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left–right determination , 2005, Nature.

[106]  P. Coulie,et al.  Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen , 2005, The Journal of experimental medicine.

[107]  J. Pollard,et al.  A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors , 2004, Cancer Research.

[108]  Dai Fukumura,et al.  Dissecting tumour pathophysiology using intravital microscopy , 2002, Nature Reviews Cancer.

[109]  A. Ghysen,et al.  Pattern formation in the lateral line of zebrafish , 2001, Mechanisms of Development.

[110]  Xin Zeng,et al.  A freely diffusible form of Sonic hedgehog mediates long-range signalling , 2001, Nature.

[111]  Thomas N. Sato,et al.  Universal GFP reporter for the study of vascular development , 2000, Genesis.

[112]  J. Segall,et al.  A critical step in metastasis: in vivo analysis of intravasation at the primary tumor. , 2000, Cancer research.

[113]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[114]  R. Baler,et al.  Genetic Targeting , 1999, Journal of neurochemistry.

[115]  T. Kornberg,et al.  Cytonemes Cellular Processes that Project to the Principal Signaling Center in Drosophila Imaginal Discs , 1999, Cell.

[116]  S. Fraser,et al.  Neural crest cell dynamics revealed by time-lapse video microscopy of whole embryo chick explant cultures. , 1998, Developmental biology.

[117]  A. Balmain,et al.  The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted , 1998, Current Biology.

[118]  Rakesh K. Jain,et al.  Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation , 1997, Nature Medicine.

[119]  Arturo Alvarez-Buylla,et al.  Chain Migration of Neuronal Precursors , 1996, Science.

[120]  R. Jain,et al.  Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. , 1992, Cancer research.

[121]  A. Spradling,et al.  slow border cells, a locus required for a developmentally regulated cell migration during oogenesis, encodes Drosophila C EBP , 1992, Cell.

[122]  K Messmer,et al.  Angiogenesis and Hemodynamics of Microvasculature of Transplanted Islets of Langerhans , 1989, Diabetes.

[123]  H. Dvorak.  Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. , 1986, The New England journal of medicine.

[124]  Clotilde Théry,et al.  CD8+ tumor-infiltrating T cells are trapped in the tumor-dendritic cell network. , 2013, Neoplasia.

[125]  R. T. Sasmono,et al.  Generation and characterization of MacGreen mice, the Cfs1r-EGFP transgenic mice. , 2012, Methods in molecular biology.

[126]  Ralph Weissleder,et al.  Intravital Imaging , 2011, Cell.

[127]  Jochen Herms,et al.  Real-time imaging reveals the single steps of brain metastasis formation , 2010, Nature Medicine.

[128]  Rudolf Jaenisch,et al.  Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells , 2009, Nature Biotechnology.

[129]  David W. Rowe,et al.  Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche , 2009, Nature.

[130]  D. Newgreen,et al.  Factors controlling the time of onset of the migration of neural crest cells in the fowl embryo , 2004, Cell and Tissue Research.

[131]  William A Mohler,et al.  Three-dimensional high-resolution second-harmonic generation imaging of endogenous structural proteins in biological tissues. , 2002, Biophysical journal.