论文信息 - Amino Acids and Peptides. Part 48. 1 Studies on the Structure of an Unexpected Reaction Product from Dipeptidyl Chloromethyl Ketone during Acid Hydrolysis 2

Amino Acids and Peptides. Part 48. 1 Studies on the Structure of an Unexpected Reaction Product from Dipeptidyl Chloromethyl Ketone during Acid Hydrolysis 2

During the course of the synthesis of peptidyl chloromethyl ketones (CMKs), it was revealed that amino acid recovery after acid hydrolysis (6 mol dm -3 HCl, 110 °C, 20 h) of dipeptidyl chloromethyl ketones was markedly low (7.1–33.7%) owing to the formation of 5-methylpyrazin-2(1H)-one derivatives during the acid hydrolysis.

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