Genetic variation in lipid desaturases and its impact on the development of human disease

[1]  B. Koletzko,et al.  Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism. , 2010, Metabolism: clinical and experimental.

[2]  G. Vereb,et al.  Rafts and the battleships of defense: the multifaceted microdomains for positive and negative signals in immune cells. , 2010, Immunology letters.

[3]  M. Zeegers,et al.  FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk. , 2010, The American journal of clinical nutrition.

[4]  C. Schneider Lipids in health and disease. , 2010, Molecular nutrition & food research.

[5]  S. Shaikh,et al.  The nutritional and clinical significance of lipid rafts , 2010, Current opinion in clinical nutrition and metabolic care.

[6]  M. Inoue,et al.  Impact of Lifestyle on Overall Cancer Risk among Japanese: The Japan Public Health Center-Based Prospective Study (JPHC Study) , 2010, Journal of epidemiology.

[7]  Christian Gieger,et al.  A genome-wide perspective of genetic variation in human metabolism , 2010, Nature Genetics.

[8]  J. Sepulveda,et al.  Variation in human erythrocyte membrane unsaturated Fatty acids: correlation with cardiovascular disease. , 2010, Archives of pathology & laboratory medicine.

[9]  D. Mehta,et al.  A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1 , 2010, Journal of Lipid Research.

[10]  Kai Simons,et al.  Lipid Rafts As a Membrane-Organizing Principle , 2010, Science.

[11]  K. Kothapalli,et al.  Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicing. , 2009, Gene.

[12]  M. Fessler,et al.  Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome , 2009, Current opinion in lipidology.

[13]  D. Lairon,et al.  Nutrigenetics: links between genetic background and response to Mediterranean-type diets , 2009, Public Health Nutrition.

[14]  J. Ntambi,et al.  Biochemical and physiological function of stearoyl-CoA desaturase. , 2009, American journal of physiology. Endocrinology and metabolism.

[15]  J. Lecerf Fatty acids and cardiovascular disease. , 2009, Nutrition reviews.

[16]  M. Miyazaki,et al.  Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. , 2009, Biochemical and biophysical research communications.

[17]  B. McManus,et al.  Despite Antiatherogenic Metabolic Characteristics, SCD1-Deficient Mice Have Increased Inflammation and Atherosclerosis , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[18]  T. Bridger Childhood obesity and cardiovascular disease. , 2009, Paediatrics & child health.

[19]  P. Kraft,et al.  Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome? , 2009, The American journal of clinical nutrition.

[20]  J. Ntambi,et al.  Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity. , 2009, Biochimica et biophysica acta.

[21]  Luigi Ferrucci,et al.  Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study , 2009, PLoS genetics.

[22]  S. Innis,et al.  Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. , 2008, The Journal of nutrition.

[23]  Amit R. Indap,et al.  Genes mirror geography within Europe , 2008, Nature.

[24]  A. Deshpande,et al.  Epidemiology of Diabetes and Diabetes-Related Complications , 2008, Physical Therapy.

[25]  Thomas Illig,et al.  FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. , 2008, The American journal of clinical nutrition.

[26]  D. Giugliano,et al.  Mediterranean dietary patterns and chronic diseases. , 2008, The American journal of clinical nutrition.

[27]  A. Sala-Vila,et al.  Fatty acid composition abnormalities in atopic disease: evidence explored and role in the disease process examined , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[28]  J. Ntambi,et al.  Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism , 2008, Current opinion in lipidology.

[29]  R. Cantor,et al.  Association of Stearoyl-CoA Desaturase 1 Activity With Familial Combined Hyperlipidemia , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[30]  P. Rzehak,et al.  Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes , 2008, British Journal of Nutrition.

[31]  M. Marmot,et al.  Dietary patterns and 15-y risks of major coronary events, diabetes, and mortality. , 2008, The American journal of clinical nutrition.

[32]  Thomas Illig,et al.  SNPs of the FADS Gene Cluster are Associated with Polyunsaturated Fatty Acids in a Cohort of Patients with Cardiovascular Disease , 2008, Lipids.

[33]  P. Calder,et al.  Gender differences in the n-3 fatty acid content of tissues , 2008, Proceedings of the Nutrition Society.

[34]  M. Miyazaki,et al.  Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. , 2007, Cell metabolism.

[35]  A. Caspi,et al.  Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism , 2007, Proceedings of the National Academy of Sciences.

[36]  Age K Smilde,et al.  Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis , 2007, Genome Biology.

[37]  E. Ingelsson,et al.  Polymorphisms in the SCD1 Gene: Associations With Body Fat Distribution and Insulin Sensitivity , 2007, Obesity.

[38]  D. Ma,et al.  Lipid mediators in membrane rafts are important determinants of human health and disease. , 2007, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[39]  Helmut Schröder,et al.  Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes. , 2007, The Journal of nutritional biochemistry.

[40]  P. Kraft,et al.  α-Linolenic acid, Δ6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction , 2007 .

[41]  D. Mutch Identifying regulatory hubs in obesity with nutrigenomics , 2006 .

[42]  L. Palmer,et al.  Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. , 2006, Human molecular genetics.

[43]  M. Miyazaki,et al.  Probing the role of stearoyl-CoA desaturase-1 in hepatic insulin resistance. , 2006, The Journal of clinical investigation.

[44]  E. Hoffman,et al.  Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. , 2005, Cell metabolism.

[45]  R. A. Igal,et al.  Stearoyl-CoA Desaturase Is Involved in the Control of Proliferation, Anchorage-independent Growth, and Survival in Human Transformed Cells* , 2005, Journal of Biological Chemistry.

[46]  Neil Mann,et al.  Origins and evolution of the Western diet: health implications for the 21st century. , 2005, The American journal of clinical nutrition.

[47]  M. McCarthy,et al.  Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism , 2004, Diabetologia.

[48]  K. Hayes,et al.  Dietary n-6 and n-3 fatty acid balance and cardiovascular health. , 2004, Annual review of nutrition.

[49]  Manabu T. Nakamura,et al.  STRUCTURE, FUNCTION, AND DIETARY REGULATION OF Δ6, Δ5, AND Δ9 DESATURASES , 2004 .

[50]  A. Lusis,et al.  Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. , 2004, The New England journal of medicine.

[51]  N. Zamaria Alteration of polyunsaturated fatty acid status and metabolism in health and disease. , 2004, Reproduction, nutrition, development.

[52]  K. Shiwaku,et al.  Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians Published, JLR Papers in Press, February 16, 2004. DOI 10.1194/jlr.M300483-JLR200 , 2004, Journal of Lipid Research.

[53]  M. Miyazaki,et al.  Recent insights into stearoyl-CoA desaturase-1 , 2003, Current opinion in lipidology.

[54]  A. Brownlie,et al.  Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia Published, JLR Papers in Press, August 16, 2002. DOI 10.1194/jlr.M200189-JLR200 , 2002, Journal of Lipid Research.

[55]  A. Simopoulos,et al.  The importance of the ratio of omega-6/omega-3 essential fatty acids. , 2002, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[56]  B. Yandell,et al.  Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[57]  Brennan Jt Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man. , 2002 .

[58]  J. Masferrer,et al.  Selective inhibition of Δ-6 desaturase impedes intestinal tumorigenesis , 2002 .

[59]  S. Nwaka,et al.  Activity of human Δ5 and Δ6 desaturases on multiple n‐3 and n‐6 polyunsaturated fatty acids , 2001 .

[60]  J. Hibbeln,et al.  Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. , 2001, Journal of lipid research.

[61]  H. Stöhr,et al.  cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. , 2000, Genomics.

[62]  H. Okuyama,et al.  n-6/n-3 Ratio of Dietary Fatty Acids Rather Than Hypercholesterolemia As the Major Risk Factor for Atherosclerosis and Coronary Heart Disease , 2000 .

[63]  P. Needleman,et al.  Identification and Characterization of a Novel Δ6/Δ5 Fatty Acid Desaturase Inhibitor As a Potential Anti-Inflammatory Agent , 1998 .

[64]  T. Nakada,et al.  Membrane fatty acid composition shows δ-6-desaturase abnormalities in Alzheimer's disease , 1990 .

[65]  D. Ma,et al.  Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimer's disease. , 2009, The Journal of nutritional biochemistry.

[66]  U. de Faire,et al.  Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance , 2009, Lipids in Health and Disease.

[67]  P. Kraft,et al.  alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. , 2007, The American journal of clinical nutrition.

[68]  K. Duffin,et al.  Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice , 2007, Lipids.

[69]  D. Giugliano,et al.  Diet and inflammation: a link to metabolic and cardiovascular diseases. , 2006, European heart journal.

[70]  Manabu T. Nakamura,et al.  Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. , 2004, Annual review of nutrition.

[71]  J. Brenna Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man. , 2002, Current opinion in clinical nutrition and metabolic care.

[72]  J. Masferrer,et al.  Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis. , 2002, Cancer letters.

[73]  N Rifai,et al.  Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk. , 2001, The American journal of clinical nutrition.

[74]  K. Duffin,et al.  Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. , 1999, Lipids.

[75]  P. Needleman,et al.  Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. , 1998, Biochemical pharmacology.

[76]  T. Nakada,et al.  Membrane fatty acid composition shows delta-6-desaturase abnormalities in Alzheimer's disease. , 1990, Neuroreport.