In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives
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E. L. Albuquerque | A. Katzin | U. L. Fulco | V. S. de Sena Pereira | Flavio da Silva Emery | Lis Lobo | F. Nogueira | J. I. Oliveira | V. F. de Andrade-Neto
[1] J. S. Militão,et al. Antimalarial ethnopharmacology in the Brazilian Amazon , 2015 .
[2] Olivier Sperandio,et al. FAF-Drugs3: a web server for compound property calculation and chemical library design , 2015, Nucleic Acids Res..
[3] Vinícius Gonçalves Maltarollo,et al. Applying machine learning techniques for ADME-Tox prediction: a review , 2015, Expert opinion on drug metabolism & toxicology.
[4] S. Bourguignon,et al. Evidences for leishmanicidal activity of the naphthoquinone derivative epoxy-α-lapachone. , 2014, Experimental parasitology.
[5] E. Padilha,et al. Evaluation of Antimalarial Activity and Toxicity of a New Primaquine Prodrug , 2014, PloS one.
[6] A. Krettli,et al. Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies , 2014, Memorias do Instituto Oswaldo Cruz.
[7] V. Andrade-Neto,et al. Comparative Study on the Antioxidant and Anti-Toxoplasma Activities of Vanillin and Its Resorcinarene Derivative , 2014, Molecules.
[8] Philip Smith,et al. Synthesis, in vitro antiplasmodial activity and cytotoxicity of a series of artemisinin-triazine hybrids and hybrid-dimers. , 2014, European journal of medicinal chemistry.
[9] M. Lafuente,et al. Magnetic isolation of Plasmodium falciparum schizonts iRBCs to generate a high parasitaemia and synchronized in vitro culture , 2014, Malaria Journal.
[10] F. Emery,et al. In vivo antimalarial activity of novel 2-hydroxy-3-anilino-1,4-naphthoquinones obtained by epoxide ring-opening reaction. , 2013, Bioorganic & medicinal chemistry letters.
[11] P. Rosenthal,et al. Biological evaluation of hydroxynaphthoquinones as anti-malarials , 2013, Malaria Journal.
[12] G. Wunderlich,et al. Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum , 2013, Malaria Journal.
[13] A. Vaidya,et al. The Antimalarial Activities of Methylene Blue and the 1,4-Naphthoquinone 3-[4-(Trifluoromethyl)Benzyl]-Menadione Are Not Due to Inhibition of the Mitochondrial Electron Transport Chain , 2013, Antimicrobial Agents and Chemotherapy.
[14] G. Lian,et al. Recent advances in predicting skin permeability of hydrophilic solutes. , 2013, Advanced drug delivery reviews.
[15] Jonathan B. Baell,et al. Broad Coverage of Commercially Available Lead-like Screening Space with Fewer than 350, 000 Compounds , 2013, J. Chem. Inf. Model..
[16] Barbara M. Bakker,et al. Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism , 2013, PLoS neglected tropical diseases.
[17] A. Hoerauf,et al. New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain. , 2012, European journal of medicinal chemistry.
[18] K. Becker,et al. Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents. , 2012, Organic & biomolecular chemistry.
[19] Jignasa K. Savjani,et al. Drug Solubility: Importance and Enhancement Techniques , 2012, ISRN pharmaceutics.
[20] Lionel Colliandre,et al. e-Drug3D: 3D structure collections dedicated to drug repurposing and fragment-based drug design , 2012, Bioinform..
[21] Koichi Wada,et al. Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications. , 2011, International journal of pharmaceutics.
[22] Joseph L. DeRisi,et al. Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum , 2011, PLoS biology.
[23] E. Kimura,et al. Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum. , 2011, Memorias do Instituto Oswaldo Cruz.
[24] V. Yardley,et al. Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites. , 2011, Journal of the American Chemical Society.
[25] E. Kimura,et al. In Vitro and In Vivo Antiplasmodial Activities of Risedronate and Its Interference with Protein Prenylation in Plasmodium falciparum , 2011, Antimicrobial Agents and Chemotherapy.
[26] P. Rosenthal,et al. Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy , 2010, Malaria Journal.
[27] F. L. D’Alexandri,et al. Intraerythrocytic stages of Plasmodium falciparum biosynthesize menaquinone , 2010, FEBS letters.
[28] Ian Collins,et al. Probing the Probes: Fitness Factors For Small Molecule Tools , 2010, Chemistry & biology.
[29] C. Humblet,et al. Escape from flatland: increasing saturation as an approach to improving clinical success. , 2009, Journal of medicinal chemistry.
[30] M. Edwards,et al. Using the Golden Triangle to optimize clearance and oral absorption. , 2009, Bioorganic & medicinal chemistry letters.
[31] A. Pawlak,et al. Tocochromanols, plastoquinol, and other biological prenyllipids as singlet oxygen quenchers-determination of singlet oxygen quenching rate constants and oxidation products. , 2008, Free radical biology & medicine.
[32] Kimberley A. Lentz,et al. Current Methods for Predicting Human Food Effect , 2008, The AAPS Journal.
[33] Daniel James,et al. Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases , 2007, ChemMedChem.
[34] S. Nunomura,et al. In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. , 2007, Memorias do Instituto Oswaldo Cruz.
[35] Alexander Hillisch,et al. In Silico ADMET Traffic Lights as a Tool for the Prioritization of HTS Hits , 2006, ChemMedChem.
[36] David S. Wishart,et al. DrugBank: a comprehensive resource for in silico drug discovery and exploration , 2005, Nucleic Acids Res..
[37] C. Laggner,et al. Why drugs fail--a study on side effects in new chemical entities. , 2005, Current pharmaceutical design.
[38] Xiaolin Ma,et al. Predictive model of blood-brain barrier penetration of organic compounds , 2005, Acta Pharmacologica Sinica.
[39] I. Tetko,et al. Application of ALOGPS to predict 1-octanol/water distribution coefficients, logP, and logD, of AstraZeneca in-house database. , 2004, Journal of pharmaceutical sciences.
[40] H. Kubinyi. Drug research: myths, hype and reality , 2003, Nature Reviews Drug Discovery.
[41] W. Patrick Walters,et al. A guide to drug discovery: Designing screens: how to make your hits a hit , 2003, Nature Reviews Drug Discovery.
[42] Manfred Kansy,et al. Predicting plasma protein binding of drugs: a new approach. , 2002, Biochemical pharmacology.
[43] Vinod P. Shah,et al. Biopharmaceutics Classification System: The Scientific Basis for Biowaiver Extensions , 2002, Pharmaceutical Research.
[44] Stephen R. Johnson,et al. Molecular properties that influence the oral bioavailability of drug candidates. , 2002, Journal of medicinal chemistry.
[45] A. Baggish,et al. Antiparasitic Agent Atovaquone , 2002, Antimicrobial Agents and Chemotherapy.
[46] A. Beresford,et al. The emerging importance of predictive ADME simulation in drug discovery. , 2002, Drug discovery today.
[47] John Hodgson,et al. ADMET—turning chemicals into drugs , 2001, Nature Biotechnology.
[48] Tudor I. Oprea,et al. Is There a Difference between Leads and Drugs? A Historical Perspective , 2001, J. Chem. Inf. Comput. Sci..
[49] U Norinder,et al. Experimental and computational screening models for the prediction of intestinal drug absorption. , 2001, Journal of medicinal chemistry.
[50] J. Dressman,et al. In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs. , 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[51] J J Baldwin,et al. Prediction of drug absorption using multivariate statistics. , 2000, Journal of medicinal chemistry.
[52] Liliana R. Stefan,et al. Multiple computer-automated structure evaluation model of the plasma protein binding affinity of diverse drugs , 2000 .
[53] Tudor I. Oprea,et al. Property distribution of drug-related chemical databases* , 2000, J. Comput. Aided Mol. Des..
[54] G. Bemis,et al. Properties of known drugs. 2. Side chains. , 1999, Journal of medicinal chemistry.
[55] Ajay,et al. Designing libraries with CNS activity. , 1999, Journal of medicinal chemistry.
[56] Xin Eric Wang,et al. Vitamin E and its function in membranes. , 1999, Progress in lipid research.
[57] D. Rees,et al. Structure of the Escherichia coli fumarate reductase respiratory complex. , 1999, Science.
[58] M. Yazdanian,et al. Correlating Partitioning and Caco-2 Cell Permeability of Structurally Diverse Small Molecular Weight Compounds , 1998, Pharmaceutical Research.
[59] S. D. Di Santi,et al. In vivo and in vitro Plasmodium falciparum resistance to chloroquine, amodiaquine and quinine in the Brazilian Amazon. , 1997, Revista do Instituto de Medicina Tropical de Sao Paulo.
[60] F. Lombardo,et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .
[61] J. Crison,et al. A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability , 1995, Pharmaceutical Research.
[62] Russell O. Potts,et al. Predicting Skin Permeability , 1992, Pharmaceutical Research.
[63] P. Artursson,et al. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. , 1991, Biochemical and biophysical research communications.
[64] C. Lambros,et al. Synchronization of Plasmodium falciparum erythrocytic stages in culture. , 1979, The Journal of parasitology.
[65] R. Trelstad,et al. The collagen of chick embryonic notochord. , 1973, Biochemical and biophysical research communications.
[66] W. R. Vaughan,et al. Naphthoquinone Antimalarials. IV-XI. Synthesis1 , 1948 .
[67] Marta Machado,et al. Whole-cell SYBR Green I assay for antimalarial activity assessment , 2016 .
[68] V. J. Peres,et al. Intraerythrocytic stages of Plasmodium falciparum biosynthesize vitamin E , 2011, FEBS letters.
[69] Brian K. Shoichet,et al. ZINC - A Free Database of Commercially Available Compounds for Virtual Screening , 2005, J. Chem. Inf. Model..
[70] J. Tolan,et al. MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening. , 1999, Journal of pharmaceutical sciences.
[71] L. Fieser,et al. Naphthoquinone antimalarials; synthesis. , 1948, Journal of the American Chemical Society.