Cancer cell plasticity during tumor progression, metastasis and response to therapy

[1]  Akiyoshi Uemura,et al.  RHOJ controls EMT-associated resistance to chemotherapy , 2023, Nature.

[2]  Camille Stephan-Otto Attolini,et al.  Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells , 2022, Nature.

[3]  C. Li,et al.  Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment , 2022, Nature Communications.

[4]  G. Hannon,et al.  The NALCN channel regulates metastasis and nonmalignant cell dissemination , 2022, Nature Genetics.

[5]  Y. Saeys,et al.  A cellular hierarchy in melanoma uncouples growth and metastasis , 2022, Nature.

[6]  E. Kenigsberg,et al.  ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung , 2022, Nature Cancer.

[7]  Tao Wang,et al.  Ectopic JAK–STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance , 2022, Nature Cancer.

[8]  L. Mazutis,et al.  Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling , 2022, Science.

[9]  P. Wirapati,et al.  Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia , 2022, Cell stem cell.

[10]  Takeshi Imamura,et al.  Cell–matrix interface regulates dormancy in human colon cancer stem cells , 2022, Nature.

[11]  G. Stassi,et al.  Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy , 2022, Nature Cancer.

[12]  S. Dietmann,et al.  Mitochondrial RNA modifications shape metabolic plasticity in metastasis , 2022, Nature.

[13]  Stephen M. Douglass,et al.  Stromal changes in the aged lung induce an emergence from melanoma dormancy , 2022, Nature.

[14]  M. Salido,et al.  p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis , 2022, Nature Communications.

[15]  P. Carmeliet,et al.  PHGDH heterogeneity potentiates cancer cell dissemination and metastasis , 2022, Nature.

[16]  M. Stratton,et al.  Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors , 2022, Nature Cancer.

[17]  Kongming Wu,et al.  Notch signaling pathway: architecture, disease, and therapeutics , 2022, Signal Transduction and Targeted Therapy.

[18]  P. Saw,et al.  Targeting CAFs to overcome anticancer therapeutic resistance. , 2022, Trends in cancer.

[19]  F. Buettner,et al.  Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer. , 2022, Cancer cell.

[20]  S. Horswell,et al.  Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization , 2022, Nature Cancer.

[21]  Catherine J. Wu,et al.  Natural Barcodes for Longitudinal Single Cell Tracking of Leukemic and Immune Cell Dynamics , 2022, Frontiers in Immunology.

[22]  G. Christofori,et al.  Distinct contributions of partial and full EMT to breast cancer malignancy. , 2021, Developmental cell.

[23]  Sendurai A Mani,et al.  Epithelial-to-Mesenchymal Plasticity in Circulating Tumor Cell Lines Sequentially Derived from a Patient with Colorectal Cancer , 2021, Cancers.

[24]  Stephanie Ma,et al.  The Role of Cancer-Associated Fibroblast as a Dynamic Player in Mediating Cancer Stemness in the Tumor Microenvironment , 2021, Frontiers in Cell and Developmental Biology.

[25]  Hongmei Zhou,et al.  Cancer-Associated Fibroblasts Facilitate Squamous Cell Carcinoma Lung Metastasis in Mice by Providing TGFβ-Mediated Cancer Stem Cell Niche , 2021, Frontiers in Cell and Developmental Biology.

[26]  A. Regev,et al.  Cycling cancer persister cells arise from lineages with distinct programs , 2021, Nature.

[27]  Howard Y. Chang,et al.  LKB1 inactivation modulates chromatin accessibility to drive metastatic progression , 2021, Nature Cell Biology.

[28]  E. Fertig,et al.  A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy , 2021, Nature Cancer.

[29]  E. Kenigsberg,et al.  Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells , 2021, Nature.

[30]  R. Kalluri,et al.  αSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression , 2021, Oncogene.

[31]  D. Lambrechts,et al.  Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma. , 2021, Cancer cell.

[32]  D. Chan,et al.  The Impact of the Tumor Microenvironment on Macrophage Polarization in Cancer Metastatic Progression , 2021, International journal of molecular sciences.

[33]  Beth K. Martin,et al.  Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states. , 2021, Cancer cell.

[34]  A. Regev,et al.  Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. , 2021, Cancer cell.

[35]  J. Visvader,et al.  A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast , 2021, The EMBO journal.

[36]  K. Tomczak,et al.  Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing , 2021, Proceedings of the National Academy of Sciences.

[37]  A. Trumpp,et al.  Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs , 2021, Nature Cancer.

[38]  F. Lemonnier,et al.  BH3 profiling identifies ruxolitinib as a promising partner for venetoclax to treat T-cell prolymphocytic leukemia. , 2021, Blood.

[39]  D. Pe’er,et al.  A gene-environment induced epigenetic program initiates tumorigenesis , 2021, Nature.

[40]  G. Bergers,et al.  The metabolism of cancer cells during metastasis , 2021, Nature Reviews Cancer.

[41]  Jordan G Bryan,et al.  An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence. , 2021, Cancer cell.

[42]  Z. Zeng,et al.  Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments , 2021, Molecular cancer.

[43]  Trevor J Pugh,et al.  Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy , 2021, Cell.

[44]  J. Massagué,et al.  Targeting metastatic cancer , 2021, Nature Medicine.

[45]  K. Mortezaee,et al.  Steps in metastasis: an updated review , 2021, Medical Oncology.

[46]  Yi-Wen Chang,et al.  STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT–MET switch and cancer metastasis , 2020, Oncogene.

[47]  X. Zhang,et al.  The bone microenvironment invigorates metastatic seeds for further dissemination , 2020, Cell.

[48]  Soon Sung Kwon,et al.  Cancer-initiating cells in human pancreatic cancer organoids are maintained by interactions with endothelial cells. , 2020, Cancer letters.

[49]  S. Shen,et al.  Persistent Cancer Cells: The Deadly Survivors , 2020, Cell.

[50]  Shivashankar H. Nagaraj,et al.  Limiting Self-Renewal of the Basal Compartment by PKA Activation Induces Differentiation and Alters the Evolution of Mammary Tumors. , 2020, Developmental cell.

[51]  L. Geris,et al.  Tumor exposed-lymphatic endothelial cells promote primary tumor growth via IL6 , 2020, Cancer letters.

[52]  Wei Sun,et al.  Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1 , 2020, Nature Communications.

[53]  S. Dawson,et al.  Non-genetic mechanisms of therapeutic resistance in cancer , 2020, Nature Reviews Cancer.

[54]  K. Mechtler,et al.  LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma , 2020, EMBO molecular medicine.

[55]  C. Klein.  Cancer progression and the invisible phase of metastatic colonization , 2020, Nature Reviews Cancer.

[56]  A. Rustgi,et al.  EMT, MET, Plasticity, and Tumor Metastasis. , 2020, Trends in cell biology.

[57]  Erin L. Schenk,et al.  Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing , 2020, Cell.

[58]  I. Spiteri,et al.  Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype , 2020, Science Translational Medicine.

[59]  T. Voet,et al.  Heterotypic cell–cell communication regulates glandular stem cell multipotency , 2020, Nature.

[60]  S. Aerts,et al.  Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma , 2020, Nature Cell Biology.

[61]  R. Hass.  Role of MSC in the Tumor Microenvironment , 2020, Cancers.

[62]  F. Camargo,et al.  Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. , 2020, Cell stem cell.

[63]  R. Derynck,et al.  TGFβ biology in cancer progression and immunotherapy , 2020, Nature Reviews Clinical Oncology.

[64]  S. Morrison,et al.  Lymph protects metastasizing melanoma cells from ferroptosis , 2020, Nature.

[65]  A. Regev,et al.  Emergence of a High-Plasticity Cell State during Lung Cancer Evolution. , 2020, Cancer cell.

[66]  Kevin Petrecca,et al.  Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy , 2020, Nature Communications.

[67]  Kathy O. Lui,et al.  Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. , 2020, Developmental cell.

[68]  Albert C. Chen,et al.  Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex. , 2020, Developmental cell.

[69]  R. Piñeiro,et al.  Analysis of a Real-World Cohort of Metastatic Breast Cancer Patients Shows Circulating Tumor Cell Clusters (CTC-clusters) as Predictors of Patient Outcomes , 2020, Cancers.

[70]  B. Faubert,et al.  Metabolic reprogramming and cancer progression , 2020, Science.

[71]  A. Regev,et al.  Transcriptional mediators of treatment resistance in lethal prostate cancer , 2020, Nature Medicine.

[72]  F. Castro-Giner,et al.  Tracking cancer progression: from circulating tumor cells to metastasis , 2020, Genome Medicine.

[73]  A. Sieuwerts,et al.  Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer , 2020, Cell stem cell.

[74]  Z. Zeng,et al.  Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal cancer. , 2020, Cancer letters.

[75]  N. Birkbak,et al.  Cancer Genome Evolutionary Trajectories in Metastasis. , 2020, Cancer cell.

[76]  Ashley M. Laughney,et al.  L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer , 2020, Nature Cancer.

[77]  V. De Maertelaer,et al.  Context Dependency of Epithelial-to-Mesenchymal Transition for Metastasis. , 2019, Cell reports.

[78]  D. Schadendorf,et al.  Metabolic heterogeneity confers differences in melanoma metastatic potential , 2019, Nature.

[79]  C. Blanpain,et al.  Spatiotemporal regulation of multipotency during prostate development , 2019, Development.

[80]  K. Vousden,et al.  Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization , 2019, Cell metabolism.

[81]  S. Kletukhina,et al.  Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Epithelial–Mesenchymal Transition , 2019, International journal of molecular sciences.

[82]  J. Mills,et al.  Nomenclature for cellular plasticity: are the terms as plastic as the cells themselves? , 2019, The EMBO journal.

[83]  Joel S. Bader,et al.  E-cadherin is required for metastasis in multiple models of breast cancer , 2019, Nature.

[84]  Mariella G. Filbin,et al.  An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma , 2019, Cell.

[85]  K. Polyak,et al.  Intratumoral Heterogeneity: More Than Just Mutations. , 2019, Trends in cell biology.

[86]  N. Nishimura,et al.  Endothelial cells promote 3D invasion of GBM by IL-8-dependent induction of cancer stem cell properties , 2019, Scientific Reports.

[87]  E. Fuchs,et al.  Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells , 2019, Cell.

[88]  Sydney M. Shaffer,et al.  Genetic screening for single-cell variability modulators driving therapy resistance , 2019, bioRxiv.

[89]  Kin F. Chan,et al.  Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell , 2019, Nature.

[90]  Shuyi Wang,et al.  Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis , 2019, Molecular Cancer.

[91]  R. Weinberg,et al.  Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells , 2019, Proceedings of the National Academy of Sciences.

[92]  Yibin Kang,et al.  Bone Vascular Niche E-selectin Induces Mesenchymal-Epithelial Transition and Wnt Activation in Cancer Cells to Promote Bone Metastasis , 2019, Nature Cell Biology.

[93]  Martin J. Aryee,et al.  Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics , 2019, Cell.

[94]  C. Blanpain,et al.  EMT Transition States during Tumor Progression and Metastasis. , 2019, Trends in cell biology.

[95]  C. Verfaillie,et al.  Breast cancer cells rely on environmental pyruvate to shape the metastatic niche , 2019, Nature.

[96]  N. Beerenwinkel,et al.  Neutrophils escort circulating tumour cells to enable cell cycle progression , 2019, Nature.

[97]  Z. Zeng,et al.  Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape , 2019, Molecular Cancer.

[98]  J. Rich,et al.  Cancer Stem Cells: The Architects of the Tumor Ecosystem. , 2019, Cell stem cell.

[99]  T. Brabletz,et al.  Non-redundant functions of EMT transcription factors , 2019, Nature Cell Biology.

[100]  Piyush B. Gupta,et al.  Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance. , 2019, Cell stem cell.

[101]  Xiaohui Zhu,et al.  Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis , 2018, Nature Communications.

[102]  J. Tabernero,et al.  A slow-cycling Lgr5 tumour population mediates basal cell carcinoma relapse after therapy , 2018, Nature.

[103]  F. Peale,et al.  A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition , 2018, Nature.

[104]  Michael S. Goldberg,et al.  Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice , 2018, Science.

[105]  S. Sleijfer,et al.  Pan-cancer whole-genome analyses of metastatic solid tumours , 2018, bioRxiv.

[106]  Margaret P. Chapman,et al.  Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer , 2018, Nature Communications.

[107]  A. Schneeweiss,et al.  Stress signaling in breast cancer cells induces matrix components that promote chemoresistant metastasis , 2018, EMBO molecular medicine.

[108]  Maria C. Lecca,et al.  Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer , 2018, Nature Cell Biology.

[109]  Zhong-hua Chu,et al.  The mechanisms of colorectal cancer cell mesenchymal–epithelial transition induced by hepatocyte exosome-derived miR-203a-3p , 2018, Journal of Bio-X Research.

[110]  H. Clevers,et al.  Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling. , 2018, Cell reports.

[111]  K. Flaherty,et al.  Toward Minimal Residual Disease-Directed Therapy in Melanoma , 2018, Cell.

[112]  F. Rojo,et al.  Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer , 2018, Nature Communications.

[113]  M. Rosenblum,et al.  Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization , 2018, Nature Cell Biology.

[114]  O. Klein,et al.  Parasitic helminthes induce fetal-like reversion in the intestinal stem cell niche , 2018, Nature.

[115]  E. Furth,et al.  EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration. , 2018, Developmental cell.

[116]  Johan Hartman,et al.  Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing , 2018, Cell.

[117]  T. Voet,et al.  Identification of the tumour transition states occurring during EMT , 2018, Nature.

[118]  P. Glazer,et al.  The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells , 2018, Breast Cancer Research.

[119]  M. Shen,et al.  Lineage Plasticity in Cancer Progression and Treatment. , 2018, Annual review of cancer biology.

[120]  R. Sachidanandam,et al.  Quiescent Tissue Stem Cells Evade Immune Surveillance , 2018, Immunity.

[121]  E. Wagner,et al.  Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas , 2018, Nature.

[122]  Camille Stephan-Otto Attolini,et al.  TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis , 2018, Nature.

[123]  H. Yao,et al.  CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness , 2018, Cell.

[124]  R. Bourgon,et al.  TGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells , 2018, Nature.

[125]  O. Nielsen,et al.  YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration , 2018, Cell stem cell.

[126]  Q. She,et al.  Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1 , 2017, Nature Communications.

[127]  A. Tsirigos,et al.  TGF-β-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma. , 2017, Cell stem cell.

[128]  Shawn M. Gillespie,et al.  Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer , 2017, Cell.

[129]  H. Clevers,et al.  Cancer stem cells revisited , 2017, Nature Medicine.

[130]  R. Kaplan,et al.  KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis , 2017, Nature Medicine.

[131]  Richard A. Moore,et al.  Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy , 2017, Nature.

[132]  P. Giresi,et al.  Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure. , 2017, Cancer cell.

[133]  Jill P. Mesirov,et al.  Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway , 2017, Nature.

[134]  Stuart L. Schreiber,et al.  Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition , 2017, Nature.

[135]  J. Thiery,et al.  New insights into the role of EMT in tumor immune escape , 2017, Molecular oncology.

[136]  Sydney M. Shaffer,et al.  Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance , 2017, Nature.

[137]  E. Batlle,et al.  A genome editing approach to study cancer stem cells in human tumors , 2017, EMBO molecular medicine.

[138]  Francisco J. Sánchez-Rivera,et al.  A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma , 2017, Nature.

[139]  Antonina V. Kurtova,et al.  A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer , 2017, Nature.

[140]  Shinya Sugimoto,et al.  Visualization and targeting of LGR5+ human colon cancer stem cells , 2017, Nature.

[141]  Thomas R. Cox,et al.  Pre-metastatic niches: organ-specific homes for metastases , 2017, Nature Reviews Cancer.

[142]  R. Weinberg,et al.  Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells , 2017, Proceedings of the National Academy of Sciences.

[143]  Shawn M. Gillespie,et al.  Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. , 2017, Cell stem cell.

[144]  Michael R. Padgen,et al.  Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments , 2017, Nature Cell Biology.

[145]  Henry W. Long,et al.  Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance , 2017, Science.

[146]  M. Rubin,et al.  SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer , 2017, Science.

[147]  Rainer Spang,et al.  Early dissemination seeds metastasis in breast cancer , 2016, Nature.

[148]  Mariella G. Filbin,et al.  Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma , 2016, Nature.

[149]  Christian Frezza,et al.  Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival , 2016, Nature Communications.

[150]  X. Bian,et al.  Cancer stem cells and their vascular niche: Do they benefit from each other? , 2016, Cancer letters.

[151]  R. Kalluri.  The biology and function of fibroblasts in cancer , 2016, Nature Reviews Cancer.

[152]  Sridhar Ramaswamy,et al.  HER2 expression identifies dynamic functional states within circulating breast cancer cells , 2016, Nature.

[153]  N. Aceto,et al.  Stem-like features of cancer cells on their way to metastasis , 2016, Biology Direct.

[154]  C. Blanpain,et al.  Cancer Stem Cells: Basic Concepts and Therapeutic Implications. , 2016, Annual review of pathology.

[155]  I. Ng,et al.  Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling. , 2016, Cell reports.

[156]  M. Shen,et al.  Basal Progenitors Contribute to Repair of the Prostate Epithelium Following Induced Luminal Anoikis , 2016, Stem cell reports.

[157]  Elisa de Stanchina,et al.  Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT , 2016, Cell.

[158]  L. Ferrucci,et al.  sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance , 2016, Nature.

[159]  Alexander van Oudenaarden,et al.  Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters. , 2016, Cell stem cell.

[160]  Marc J. Williams,et al.  Identification of neutral tumor evolution across cancer types , 2016, Nature Genetics.

[161]  M. Miyazaki,et al.  Prrx1 isoform switching regulates pancreatic cancer invasion and metastatic colonization , 2016, Genes & development.

[162]  S. Durinck,et al.  Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function , 2015, Nature.

[163]  J. Theys,et al.  Targeting Notch to overcome radiation resistance , 2015, Oncotarget.

[164]  C. Nervi,et al.  Epigenetic treatment of solid tumours: a review of clinical trials , 2015, Clinical Epigenetics.

[165]  Erik Sahai,et al.  Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization , 2015, Cell reports.

[166]  Yang Xie,et al.  Phase 1 study of romidepsin plus erlotinib in advanced non-small cell lung cancer. , 2015, Lung cancer.

[167]  J. Wrana,et al.  Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer , 2015, Nature.

[168]  Jeong-Seok Nam,et al.  Combinatorial TGF-β attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells , 2015, Oncotarget.

[169]  Chih-Yang Wang,et al.  Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells , 2015, Nature.

[170]  R. Deberardinis,et al.  Oxidative stress inhibits distant metastasis by human melanoma cells , 2015, Nature.

[171]  Mehmet Toner,et al.  En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition. , 2015, Trends in cancer.

[172]  May Yin Lee,et al.  Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity , 2015, Nature.

[173]  Michael B. Stadler,et al.  PIK3CAH1047R induces multipotency and multi-lineage mammary tumours , 2015, Nature.

[174]  Michael Kahn,et al.  Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update , 2015, Nature Reviews Clinical Oncology.

[175]  Hwa-Yong Lee,et al.  Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype , 2015, Scientific Reports.

[176]  Borja Saez,et al.  Parent stem cells can serve as niches for their own daughter cells , 2015, Nature.

[177]  Albert C. Chen,et al.  Matrix stiffness drives Epithelial-Mesenchymal Transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway , 2015, Nature Cell Biology.

[178]  L. Borsu,et al.  RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer , 2015, Cancer.

[179]  Steffen Dickopf,et al.  A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis , 2015, Nature.

[180]  G. Getz,et al.  RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer , 2015, Nature Communications.

[181]  Z. Werb,et al.  The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? , 2015, Cell stem cell.

[182]  Takanori Kanai,et al.  Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids , 2015, Nature Medicine.

[183]  F. Dautry,et al.  SMAD signaling and redox imbalance cooperate to induce prostate cancer cell dormancy , 2015, Cell cycle.

[184]  Stephen T. C. Wong,et al.  The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. , 2015, Cancer cell.

[185]  M. Tan,et al.  The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism. , 2015, Cancer letters.

[186]  T. Welling,et al.  Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. , 2014, Gastroenterology.

[187]  Ben S. Wittner,et al.  Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells , 2014, Cell reports.

[188]  S. Carr,et al.  A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages , 2014, Nature Cell Biology.

[189]  E. Fuchs,et al.  Plasticity of epithelial stem cells in tissue regeneration , 2014, Science.

[190]  S. Rorive,et al.  SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma , 2014, Nature.

[191]  J. Huse,et al.  Osteopontin-CD44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth. , 2014, Cell stem cell.

[192]  A. Krešo,et al.  Evolution of the cancer stem cell model. , 2014, Cell stem cell.

[193]  Christopher J. Ott,et al.  An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia , 2014, Nature Genetics.

[194]  M. Kris,et al.  Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis , 2014, Cell.

[195]  F. D. de Sauvage,et al.  Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration. , 2014, Cell stem cell.

[196]  M. Ittmann,et al.  Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin , 2013, Proceedings of the National Academy of Sciences.

[197]  F. Giancotti.  Mechanisms Governing Metastatic Dormancy and Reactivation , 2013, Cell.

[198]  P. Bragado,et al.  TGFβ2 dictates disseminated tumour cell fate in target organs through TGFβ-RIII and p38α/β signalling , 2013, Nature Cell Biology.

[199]  Panteleimon Rompolas,et al.  Spatial organization within a niche as a determinant of stem cell fate , 2013, Nature.

[200]  Berthold Göttgens,et al.  The Epidermis Comprises Autonomous Compartments Maintained by Distinct Stem Cell Populations , 2013, Cell stem cell.

[201]  Tim Holland-Letz,et al.  Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay , 2013, Nature Biotechnology.

[202]  R. Russell,et al.  Intestinal label-retaining cells are secretory precursors expressing Lgr5 , 2013, Nature.

[203]  Sridhar Ramaswamy,et al.  Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition , 2013, Science.

[204]  H. Clevers,et al.  Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties , 2013, Cell.

[205]  M. Nieto,et al.  Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. , 2012, Cancer cell.

[206]  Jing Yang,et al.  Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. , 2012, Cancer cell.

[207]  K. Jensen,et al.  Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. , 2012, Cancer cell.

[208]  R. Kageyama,et al.  Dclk1 distinguishes between tumor and normal stem cells in the intestine , 2012, Nature Genetics.

[209]  C. Blanpain,et al.  Multipotent and unipotent progenitors contribute to prostate postnatal development , 2012, Nature Cell Biology.

[210]  G. Bell,et al.  Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy , 2012, Proceedings of the National Academy of Sciences.

[211]  A. Oudenaarden,et al.  Dll1+ secretory progenitor cells revert to stem cells upon crypt damage , 2012, Nature Cell Biology.

[212]  Sylvain Brohée,et al.  Distinct contribution of stem and progenitor cells to epidermal maintenance , 2012, Nature.

[213]  Melanie A. Huntley,et al.  Recurrent R-spondin fusions in colon cancer , 2012, Nature.

[214]  Hans Clevers,et al.  Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas , 2012, Science.

[215]  Judith Campisi,et al.  Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B , 2012, Nature Medicine.

[216]  Benjamin D. Simons,et al.  Defining the mode of tumour growth by clonal analysis , 2012, Nature.

[217]  Tzong-Shiue Yu,et al.  A restricted cell population propagates glioblastoma growth following chemotherapy , 2012, Nature.

[218]  Jane Fridlyand,et al.  Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors , 2012, Nature.

[219]  T. Golub,et al.  Tumor microenvironment induces innate RAF-inhibitor resistance through HGF secretion , 2012, Nature.

[220]  K. Polyak,et al.  Intra-tumour heterogeneity: a looking glass for cancer? , 2012, Nature Reviews Cancer.

[221]  M. Ittmann,et al.  Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. , 2012, Cancer cell.

[222]  A. Rocha,et al.  Distinct stem cells contribute to mammary gland development and maintenance , 2011, Nature.

[223]  P. Carmeliet,et al.  A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumours , 2011, Nature.

[224]  O. Klein,et al.  A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable , 2011, Nature.

[225]  D. Planchard,et al.  Detection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer , 2011, British Journal of Cancer.

[226]  Richard O Hynes,et al.  Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. , 2011, Cancer cell.

[227]  Mauro Biffoni,et al.  Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells , 2011, Nature.

[228]  Hideaki Tahara,et al.  Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells , 2011, Proceedings of the National Academy of Sciences.

[229]  Hans Clevers,et al.  The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. , 2011, Cell stem cell.

[230]  S. Pastorino,et al.  Transdifferentiation of glioblastoma cells into vascular endothelial cells , 2011, Proceedings of the National Academy of Sciences.

[231]  Rong Wang,et al.  Glioblastoma stem-like cells give rise to tumour endothelium , 2010, Nature.

[232]  A. Ashworth,et al.  BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. , 2010, Cell stem cell.

[233]  Alexander Roesch,et al.  A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth , 2010, Cell.

[234]  Louis Vermeulen,et al.  Wnt activity defines colon cancer stem cells and is regulated by the microenvironment , 2010, Nature Cell Biology.

[235]  Ben S. Wittner,et al.  A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations , 2010, Cell.

[236]  N. Ferrara,et al.  Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development , 2010, Cell.

[237]  M. Shen,et al.  A luminal epithelial stem cell that is a cell of origin for prostate cancer , 2009, Nature.

[238]  H. Clevers,et al.  Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche , 2009, Nature.

[239]  Andreas Trumpp,et al.  IFNα activates dormant haematopoietic stem cells in vivo , 2009, Nature.

[240]  Hans Clevers,et al.  Lgr5 marks cycling, yet long-lived, hair follicle stem cells , 2008, Nature Genetics.

[241]  S. Morrison,et al.  Efficient tumor formation by single human melanoma cells , 2008, Nature.

[242]  M. Todaro,et al.  Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity , 2008, Proceedings of the National Academy of Sciences.

[243]  A. Puisieux,et al.  Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition , 2008, PloS one.

[244]  Wenjun Guo,et al.  The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells , 2008, Cell.

[245]  Lloyd J. Old,et al.  Adaptive immunity maintains occult cancer in an equilibrium state , 2007, Nature.

[246]  H. Clevers,et al.  Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.

[247]  C. Heeschen,et al.  Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. , 2007, Cell stem cell.

[248]  Michael F. Clarke,et al.  Phenotypic characterization of human colorectal cancer stem cells , 2007, Proceedings of the National Academy of Sciences.

[249]  Benjamin D. Simons,et al.  A single type of progenitor cell maintains normal epidermis , 2007, Nature.

[250]  L. Ricci-Vitiani,et al.  Identification and expansion of human colon-cancer-initiating cells , 2007, Nature.

[251]  J. Dick,et al.  A human colon cancer cell capable of initiating tumour growth in immunodeficient mice , 2007, Nature.

[252]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[253]  Haiyan I. Li,et al.  Purification and unique properties of mammary epithelial stem cells , 2006, Nature.

[254]  François Vaillant,et al.  Generation of a functional mammary gland from a single stem cell , 2006, Nature.

[255]  Jane Q. Nguyen,et al.  Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis , 2005, Nature Medicine.

[256]  R. Henkelman,et al.  Identification of human brain tumour initiating cells , 2004, Nature.

[257]  Michael Karin,et al.  IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer , 2004, Cell.

[258]  S. Ramaswamy,et al.  Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis , 2004, Cell.

[259]  E. Fuchs,et al.  Defining the Epithelial Stem Cell Niche in Skin , 2004, Science.

[260]  M. Rubin,et al.  E-cadherin expression in primary carcinomas of the breast and its distant metastases , 2003, Breast Cancer Research.

[261]  S. Morrison,et al.  Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[262]  M. Caligiuri,et al.  A cell initiating human acute myeloid leukaemia after transplantation into SCID mice , 1994, Nature.

[263]  J. Gurdon,et al.  The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. , 1962, Journal of embryology and experimental morphology.

[264]  H. Thé.  Differentiation therapy revisited , 2018, Nature Reviews Cancer.

[265]  Hushan Yang,et al.  Longitudinally collected CTCs and CTC-clusters and clinical outcomes of metastatic breast cancer , 2016, Breast Cancer Research and Treatment.

[266]  D. Jaffe.  In Vivo Lineage Tracing Defines the Role of Acinar-to-Ductal Transdifferentiation in Inflammatory Ductal Metaplasia , 2008 .

[267]  Lars Holmgren,et al.  Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression , 1995, Nature Medicine.