Can Digital Tools Be Used for Improving Immunization Programs?

In order to successfully control and eliminate vaccine-preventable infectious diseases, an appropriate vaccine coverage has to be achieved and maintained. This task requires a high level of effort as it may be compromised by a number of barriers. Public health agencies have issued specific recommendations to address these barriers and therefore improve immunization programs. In the present review, we characterize issues and challenges of immunization programs for which digital tools are a potential solution. In particular, we explore previously published research on the use of digital tools in the following vaccine-related areas: immunization registries, dose tracking, and decision support systems; vaccine-preventable diseases surveillance; surveillance of adverse events following immunizations; vaccine confidence monitoring; and delivery of information on vaccines to the public. Subsequently, we analyze the limits of the use of digital tools in such contexts and envision future possibilities and challenges.

[1]  Susanne Larrabee,et al.  Recognizing the institutional benefits of bar-code point-of-care technology. , 2003, Joint Commission journal on quality and safety.

[2]  S. Kalichman,et al.  Vaccine-Related Internet Search Activity Predicts H1N1 and HPV Vaccine Coverage: Implications for Vaccine Acceptance , 2015, Journal of health communication.

[3]  Daniela Paolotti,et al.  The representativeness of a European multi-center network for influenza-like-illness participatory surveillance , 2014, BMC Public Health.

[4]  J. Brownstein,et al.  Social and news media enable estimation of epidemiological patterns early in the 2010 Haitian cholera outbreak. , 2012, The American journal of tropical medicine and hygiene.

[5]  O. Wichmann,et al.  Knowledge, attitude, and uptake related to human papillomavirus vaccination among young women in Germany recruited via a social media site , 2014, Human vaccines & immunotherapeutics.

[6]  Marientina Gotsis,et al.  Social media microblogs as an HPV vaccination forum , 2013, Human vaccines & immunotherapeutics.

[7]  Paola Velardi,et al.  Influenza-Like Illness Surveillance on Twitter through Automated Learning of Naïve Language , 2013, PloS one.

[8]  Manish M Patel,et al.  Monovalent rotavirus vaccine provides protection against an emerging fully heterotypic G9P[4] rotavirus strain in Mexico. , 2011, The Journal of infectious diseases.

[9]  P. Lopalco,et al.  The complementary roles of Phase 3 trials and post-licensure surveillance in the evaluation of new vaccines. , 2015, Vaccine.

[10]  Rumi Chunara,et al.  Public health for the people: participatory infectious disease surveillance in the digital age , 2014, Emerging Themes in Epidemiology.

[11]  Jeanette B. Ruiz,et al.  Understanding vaccination resistance: vaccine search term selection bias and the valence of retrieved information. , 2014, Vaccine.

[12]  Xiaozhen Du,et al.  Effectiveness of a smart phone app on improving immunization of children in rural Sichuan Province, China: study protocol for a paired cluster randomized controlled trial , 2014, BMC Public Health.

[13]  S Andrew Spooner,et al.  Special Requirements of Electronic Health Record Systems in Pediatrics , 2007, Pediatrics.

[14]  C. Dalton,et al.  Vaxtracker: Active on-line surveillance for adverse events following inactivated influenza vaccine in children. , 2014, Vaccine.

[15]  A. Dempsey,et al.  A pilot study on the effects of individually tailored education for MMR vaccine-hesitant parents on MMR vaccination intention , 2013, Human vaccines & immunotherapeutics.

[16]  H. Abenhaim,et al.  Google and Women’s Health-Related Issues: What Does the Search Engine Data Reveal? , 2014, Online journal of public health informatics.

[17]  Virgílio A. F. Almeida,et al.  Dengue surveillance based on a computational model of spatio-temporal locality of Twitter , 2011, WebSci '11.

[18]  K. Wilson,et al.  An analysis of the Human Papilloma Virus vaccine debate on MySpace blogs. , 2010, Vaccine.

[19]  Glen Nowak,et al.  Confidence about vaccines in the United States: understanding parents' perceptions. , 2011, Health affairs.

[20]  S. Clark,et al.  Parents' Experiences With and Preferences for Immunization Reminder/Recall Technologies , 2011, Pediatrics.

[21]  Ali M Shropshire,et al.  Mass Media Campaign Impacts Influenza Vaccine Obtainment of University Students , 2013, Journal of American college health : J of ACH.

[22]  S. Nundy,et al.  A Web-Based Patient Tool for Preventive Health , 2012, Journal of primary care & community health.

[23]  David A. Moskowitz,et al.  The role of media and the Internet on vaccine adverse event reporting: a case study of human papillomavirus vaccination. , 2014, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[24]  Louis M Bell,et al.  Impact of Electronic Health Record-Based Alerts on Influenza Vaccination for Children With Asthma , 2009, Pediatrics.

[25]  Cesira Pasquarella,et al.  Effectiveness of interventions that apply new media to improve vaccine uptake and vaccine coverage , 2015, Human vaccines & immunotherapeutics.

[26]  T. Lancet Supply and safety issues surrounding an H1N1 vaccine , 2009, The Lancet.

[27]  J. Brownstein,et al.  A Case Study of the New York City 2012-2013 Influenza Season With Daily Geocoded Twitter Data From Temporal and Spatiotemporal Perspectives , 2014, Journal of medical Internet research.

[28]  David M. Pennock,et al.  Using internet searches for influenza surveillance. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[29]  J. Hamid,et al.  The integration of barcode scanning technology into Canadian public health immunization settings. , 2014, Vaccine.

[30]  W. Schaffner,et al.  A randomized trial to increase acceptance of childhood vaccines by vaccine-hesitant parents: a pilot study. , 2013, Academic pediatrics.

[31]  Flavie Goutard,et al.  Use of a Text Message-Based Pharmacovigilance Tool in Cambodia: Pilot Study , 2013, Journal of medical Internet research.

[32]  A. Haines,et al.  The effectiveness of M-health technologies for improving health and health services: a systematic review protocol , 2010, BMC Research Notes.

[33]  Jaranit Kaewkungwal,et al.  Application of smart phone in "Better Border Healthcare Program": A module for mother and child care , 2010, BMC Medical Informatics Decis. Mak..

[34]  Eric Mykhalovskiy,et al.  The Global Public Health Intelligence Network and early warning outbreak detection: a Canadian contribution to global public health. , 2006, Canadian journal of public health = Revue canadienne de sante publique.

[35]  C. Dolea,et al.  World Health Organization , 1949, International Organization.

[36]  David C Grossman,et al.  Integrated Personal Health Record Use: Association With Parent-Reported Care Experiences , 2012, Pediatrics.

[37]  Gaetano Borriello,et al.  Digitizing paper forms with mobile imaging technologies , 2012, ACM DEV '12.

[38]  A Vespignani,et al.  Web‐based participatory surveillance of infectious diseases: the Influenzanet participatory surveillance experience , 2013, Clinical Microbiology and Infection.

[39]  J S Brownstein,et al.  An overview of internet biosurveillance. , 2013, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[40]  L E Rodewald,et al.  Reviews of evidence regarding interventions to improve vaccination coverage in children, adolescents, and adults. The Task Force on Community Preventive Services. , 2000, American journal of preventive medicine.

[41]  Diane P. Martin,et al.  Development of a survey to identify vaccine-hesitant parents , 2011, Human vaccines.

[42]  M. Nowalk,et al.  Using Facebook™ to Recruit College-Age Men for a Human Papillomavirus Vaccine Trial , 2016, American journal of men's health.

[43]  George Reynolds,et al.  Smartphone preventive health care: parental use of an immunization reminder system. , 2014, Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners.

[44]  R. Pebody,et al.  Vaccine registers--experiences from Europe and elsewhere. , 2012, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[45]  R. Loomis,et al.  Prospective cost-benefit analysis of a two-dimensional barcode for vaccine production, clinical documentation, and public health reporting and tracking. , 2013, Vaccine.

[46]  G. Tomlinson,et al.  YouTube as a source of information on immunization: a content analysis. , 2007, JAMA.

[47]  P L Miller,et al.  Tools for immunization guideline knowledge maintenance. II. Automated Web-based generation of user-customized test cases. , 1998, Computers and biomedical research, an international journal.

[48]  Jeremy Ginsberg,et al.  Detecting influenza epidemics using search engine query data , 2009, Nature.

[49]  A. Holton,et al.  Twitter as a source of vaccination information: content drivers and what they are saying. , 2013, American journal of infection control.

[50]  Farah Magrabi,et al.  Impact of a web-based personally controlled health management system on influenza vaccination and health services utilization rates: a randomized controlled trial , 2012, J. Am. Medical Informatics Assoc..

[51]  P. Lopalco,et al.  Actual immunization coverage throughout Europe: are existing data sufficient? , 2014, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[52]  D. Bates,et al.  How can information technology improve patient safety and reduce medication errors in children's health care? , 2001, Archives of pediatrics & adolescent medicine.

[53]  G. Eysenbach Infodemiology and Infoveillance: Framework for an Emerging Set of Public Health Informatics Methods to Analyze Search, Communication and Publication Behavior on the Internet , 2009, Journal of medical Internet research.

[54]  Dana R. Thomson,et al.  Using Mobile Health (mHealth) and Geospatial Mapping Technology in a Mass Campaign for Reactive Oral Cholera Vaccination in Rural Haiti , 2014, PLoS neglected tropical diseases.

[55]  G. Merekoulias,et al.  Mass psychogenic illness in nationwide in-school vaccination for pandemic influenza A ( H 1 N 1 ) 2009 , Taiwan , November 2009 – January 2010 , 2010 .

[56]  M. Partinen,et al.  Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland , 2012, PloS one.

[57]  Xiaoli Nan,et al.  Sorting through search results: a content analysis of HPV vaccine information online. , 2012, Vaccine.

[58]  Russ Burtner,et al.  INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS REVIEW Open Access , 2022 .

[59]  S. Garland,et al.  Asking about human papillomavirus vaccination and the usefulness of registry validation: a study of young women recruited using Facebook. , 2015, Vaccine.

[60]  G. Rodier,et al.  Hot spots in a wired world: WHO surveillance of emerging and re-emerging infectious diseases. , 2001, The Lancet. Infectious diseases.

[61]  Stephen P. Lewis,et al.  Googling Self-injury: the state of health information obtained through online searches for self-injury. , 2014, JAMA pediatrics.

[62]  Perry L. Miller,et al.  Issues in accommodating national changes and local variation in a computer-based guideline for childhood immunization and in related knowledge maintenance tools , 1998, AMIA.

[63]  Horace J Spencer,et al.  A novel use of a statewide telecolposcopy network for recruitment of participants in a Phase I clinical trial of a human papillomavirus therapeutic vaccine , 2015, Clinical trials.

[64]  Progress in immunization information systems --- United States, 2009. , 2011, MMWR. Morbidity and mortality weekly report.

[65]  Rishi Desai,et al.  Use of Internet search data to monitor impact of rotavirus vaccination in the United States. , 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[66]  Steven J. Jacobsen,et al.  The Vaccine Safety Datalink: A Model for Monitoring Immunization Safety , 2011, Pediatrics.

[67]  Vivienne J. Zhu,et al.  Evaluation of a clinical decision support algorithm for patient-specific childhood immunization , 2012, Artif. Intell. Medicine.

[68]  William R. Hersh,et al.  A survey of current work in biomedical text mining , 2005, Briefings Bioinform..

[69]  A D LANGMUIR,et al.  The surveillance of communicable diseases of national importance. , 1963, The New England journal of medicine.

[70]  D. Cummings,et al.  Prediction of Dengue Incidence Using Search Query Surveillance , 2011, PLoS neglected tropical diseases.

[72]  Kumanan Wilson,et al.  Social Media and the Empowering of Opponents of Medical Technologies: The Case of Anti-Vaccinationism , 2013, Journal of medical Internet research.

[73]  W Katherine Yih,et al.  Surveillance for adverse events following receipt of pandemic 2009 H1N1 vaccine in the Post-Licensure Rapid Immunization Safety Monitoring (PRISM) System, 2009-2010. , 2012, American journal of epidemiology.

[74]  C. Wheeler,et al.  Beta-Test Results for an HPV Information Web Site: GoHealthyGirls.org—Increasing HPV Vaccine Uptake in the United States , 2014, Journal of consumer health on the Internet.

[75]  Gail M Williams,et al.  Internet-based surveillance systems for monitoring emerging infectious diseases , 2013, The Lancet Infectious Diseases.

[76]  Xiaoli Nan,et al.  HPV Vaccine Information in the Blogosphere: How Positive and Negative Blogs Influence Vaccine-Related Risk Perceptions, Attitudes, and Behavioral Intentions , 2012, Health communication.

[77]  T. Wetter,et al.  Engaging Patients through Mobile Phones: Demonstrator Services, Success Factors, and Future Opportunities in Low and Middle-income Countries , 2014, Yearbook of Medical Informatics.

[78]  L. Moulton,et al.  Parents' Source of Vaccine Information and Impact on Vaccine Attitudes, Beliefs, and Nonmedical Exemptions , 2012, Advances in preventive medicine.

[79]  Jessica J. Hale,et al.  Vaccine hesitancy among parents of adolescents and its association with vaccine uptake. , 2015, Vaccine.

[80]  S. Öncel,et al.  How reliable is the Internet for caregivers on their decision to vaccinate their child against influenza? Results from googling in two languages , 2013, European Journal of Pediatrics.

[81]  D. Salmon,et al.  Pertussis Resurgence and Vaccine Uptake: Implications for Reducing Vaccine Hesitancy , 2014, Pediatrics.

[82]  A. Hall,et al.  The Global Eradication of Smallpox. Final Report of the Global Commission for the Certification of Smallpox Eradication , 1982 .

[83]  John S Brownstein,et al.  Measuring vaccine confidence: analysis of data obtained by a media surveillance system used to analyse public concerns about vaccines. , 2013, The Lancet. Infectious diseases.

[84]  Michael J. Paul,et al.  National and Local Influenza Surveillance through Twitter: An Analysis of the 2012-2013 Influenza Epidemic , 2013, PloS one.

[85]  M. Stockwell,et al.  Utilizing health information technology to improve vaccine communication and coverage , 2013, Human vaccines & immunotherapeutics.

[86]  Marcel Salathé,et al.  Assessing Vaccination Sentiments with Online Social Media: Implications for Infectious Disease Dynamics and Control , 2011, PLoS Comput. Biol..

[87]  G. Eysenbach,et al.  Pandemics in the Age of Twitter: Content Analysis of Tweets during the 2009 H1N1 Outbreak , 2010, PloS one.

[88]  H. D. de Melker,et al.  Parental information-seeking behaviour in childhood vaccinations , 2013, BMC Public Health.

[89]  Bettina Berendt Text Mining for News and Blogs Analysis , 2017, Encyclopedia of Machine Learning and Data Mining.

[90]  John S. Brownstein,et al.  Evaluation of Local Media Surveillance for Improved Disease Recognition and Monitoring in Global Hotspot Regions , 2014, PloS one.

[91]  Rossella Zucco,et al.  Parents Seeking Health-Related Information on the Internet: Cross-Sectional Study , 2013, Journal of medical Internet research.

[92]  H. Witteman,et al.  The defining characteristics of Web 2.0 and their potential influence in the online vaccination debate. , 2012, Vaccine.