Development of a hand-held TPI system for medical applications

Terahertz pulsed imaging (TPI) is an emerging modality for medical applications. TPI uses pulses of electromagnetic radiation covering a frequency range of 0.1-3 terahertz. These frequencies are nonionizing, provide submillimeter resolution and penetrate several millimeters into tissue. We have developed a fiber coupled hand held TPI scanner for use in medical imaging. We report on preliminary studies using the system in dermatological applications. This study demonstrates the potential of TPI to image skin and encourages further studies in using the system as a surgical aid for identifying tumor margins.

[1]  R H Clothier,et al.  Effects of THz Exposure on Human Primary Keratinocyte Differentiation and Viability , 2003, Journal of biological physics.

[2]  V. Wallace,et al.  In vivo study of human skin using pulsed terahertz radiation , 2004, Physics in medicine and biology.

[3]  V. Wallace,et al.  Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo , 2004, The British journal of dermatology.

[4]  M. Nuss,et al.  Imaging with terahertz waves. , 1995, Optics letters.

[5]  R. E. Miles,et al.  Do in vivo terahertz imaging systems comply with safety guidelines , 2003 .

[6]  D. Auston Picosecond optoelectronic switching and gating in silicon , 1975 .

[7]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[8]  Bryan Edward Cole,et al.  Three-dimensional terahertz pulse imaging of dental tissue , 2002, SPIE LASE.

[9]  E. Linfield,et al.  Terahertz pulse imaging of ex vivo basal cell carcinoma. , 2003, The Journal of investigative dermatology.