The effect of inhaled thiorphan on allergen‐induced airway responses in asthmatic subjects

Background Neuropeptides are likely to be implicated in the pathophysiology of allergen‐induced airway responses. However, upon release in the airways, neuropeptides are potentially inactivated by neutral endopeptidase (NEP). Objective We hypothesized that NEP‐inhibition by inhaled thiorphan (TH) would increase allergen‐induced early (EAR) and late (LAR) asthmatic responses, and allergen‐induced airway hyperresponsiveness to histamine in asthmatic subjects in vivo. The dose and dosing intervals of TH were derived from previous pharmacokinetic and dose‐finding studies.

[1]  D. Cockcroft,et al.  Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine. , 2015, The American review of respiratory disease.

[2]  A. Mistretta,et al.  Effect of an inhaled neutral endopeptidase inhibitor, phosphoramidon, on baseline airway calibre and bronchial responsiveness to bradykinin in asthma. , 1995, Thorax.

[3]  A. Mistretta,et al.  Neutral endopeptidase inhibitor thiorphan increases airway narrowing to inhaled sodium metabisulfite in normal subjects. , 1994, American journal of respiratory and critical care medicine.

[4]  P. Sterk,et al.  Effects of inhaled substance P on airway responsiveness to methacholine in asthmatic subjects in vivo. , 1994, Journal of applied physiology.

[5]  R. Pauwels,et al.  Sensory neuropeptides and the human lower airways: present state and future directions. , 1994, The European respiratory journal.

[6]  J. Drazen,et al.  Effects of chronic airway inflammation on the activity and enzymatic inactivation of neuropeptides in guinea pig lungs. , 1994, The Journal of clinical investigation.

[7]  P. Sterk,et al.  Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects. , 1994, The European respiratory journal.

[8]  A. Zwinderman,et al.  Neutral endopeptidase activity and airway hyperresponsiveness to neurokinin A in asthmatic subjects in vivo. , 1993, The American review of respiratory disease.

[9]  T. Hsiue,et al.  Impaired sensorineural function after allergen-induced mediator release. , 1993, The American review of respiratory disease.

[10]  H. Kohrogi,et al.  Neutral endopeptidase inhibitor potentiates allergic bronchoconstriction in guinea pigs in vivo. , 1993, Journal of applied physiology.

[11]  J. Roche,et al.  Modulation of T lymphocyte function by neuropeptides. Evidence for their role as local immunoregulatory elements. , 1993, Journal of immunology.

[12]  A. Foresi,et al.  Reproducibility of allergen-induced asthma and associated increase in bronchial responsiveness to methacholine in asthmatic children. , 1993, Annals of allergy.

[13]  F. Nijkamp,et al.  Capsaicin pretreatment of guinea pigs in vivo prevents ovalbumin-induced tracheal hyperreactivity in vitro. , 1993, European journal of pharmacology.

[14]  M. Fournié-Zaluski,et al.  Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology. , 1993, Pharmacological reviews.

[15]  J E Cotes,et al.  Lung volumes and forced ventilatory flows , 1993, European Respiratory Journal.

[16]  E. Juniper,et al.  Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults , 1993, European Respiratory Journal.

[17]  S. Anderson,et al.  Airway responsiveness : standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults , 1993 .

[18]  C. Bertrand,et al.  Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea. , 1993, Journal of immunology.

[19]  Z. Tomori,et al.  Comparison of inspiratory effort in sniff-like aspiration reflex, gasping and normal breathing in cats. , 1993, The European respiratory journal.

[20]  D. Agrawal,et al.  Neuropeptides modulate human eosinophil chemotaxis. , 1992, Journal of immunology.

[21]  J. Furkert,et al.  Substance P and beta-endorphin-like immunoreactivity in lavage fluids of subjects with and without allergic asthma. , 1992, The Journal of allergy and clinical immunology.

[22]  P. Sterk,et al.  The effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responses to neurokinin A in normal humans in vivo. , 1992, The American review of respiratory disease.

[23]  R. Schellenberg,et al.  Capsaicin inhibits airway hyperresponsiveness but not lipoxygenase activity or eosinophilia after repeated aerosolized antigen in guinea pigs. , 1991, The American review of respiratory disease.

[24]  A. Woolcock,et al.  Substance P immunoreactive nerves in airways from asthmatics and nonasthmatics. , 1991, The European respiratory journal.

[25]  J. Nadel.  Regulation of neurogenic inflammation by neutral endopeptidase. , 1991, The American review of respiratory disease.

[26]  E. Ingenito,et al.  Effects of capsaicin on mechanical, cellular, and mediator responses to antigen in sensitized guinea pigs. , 1991, The American review of respiratory disease.

[27]  J. Lötvall,et al.  Capsaicin pretreatment does not inhibit allergen‐induced airway microvascular leakage in guinea pig , 1991, Allergy.

[28]  J. Nadel,et al.  Virus induces airway hyperresponsiveness to tachykinins: role of neutral endopeptidase. , 1989, Journal of applied physiology.

[29]  J. Nadel,et al.  Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig. Possible role of free radicals. , 1989, The Journal of clinical investigation.

[30]  M. Waldrop.  NASA Delays Space Telescope. , 1988, Science.

[31]  D. Carson,et al.  Effect of neuropeptides on production of inflammatory cytokines by human monocytes , 1988 .

[32]  A. Mistretta,et al.  Effect of nedocromil on bronchospasm induced by inhalation of substance P in asthmatic subjects , 1988, Clinical allergy.

[33]  D. Sheppard,et al.  Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase. , 1988, The Journal of clinical investigation.

[34]  R. Pauwels,et al.  Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects. , 1987, Thorax.

[35]  C. Maggi,et al.  Capsaicin desensitization protects from antigen-induced bronchospasm in conscious guinea-pigs. , 1987, European journal of pharmacology.

[36]  T. Takishima,et al.  Dysfunction of nonadrenergic noncholinergic inhibitory system after antigen inhalation in actively sensitized cat airways. , 1992, The American review of respiratory disease.

[37]  P. Barnes,et al.  Neuropeptides in the respiratory tract. Part II. , 1991, The American review of respiratory disease.

[38]  S. Silbaugh,et al.  Effects of inhaled or intravenous thiorphan on substance P-induced airway obstruction. , 1991, Agents and actions. Supplements.

[39]  I. Honda,et al.  Inhibition of neutral endopeptidase potentiates bronchial contraction induced by immune response in guinea pigs in vitro. , 1991, The American review of respiratory disease.