Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates.

[1]  W. Dekant,et al.  Bacterial beta-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene. , 1986, Chemico-biological interactions.

[2]  M. Metzler,et al.  Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats. , 1986, Biochemical pharmacology.

[3]  M. Metzler,et al.  Identification of S-1,2,2-trichlorovinyl-N-acetylcysteine as a urinary metabolite of tetrachloroethylene: bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity. , 1986, Journal of biochemical toxicology.

[4]  L. Lash,et al.  Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane. , 1986, The Journal of biological chemistry.

[5]  S. Schütz,et al.  Mercapturic acid formation is an activation and intermediary step in the metabolism of hexachlorobutadiene. , 1986, Biochemical pharmacology.

[6]  M. W. Anders,et al.  Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity. , 1986, Biochemical pharmacology.

[7]  L. Lash,et al.  Nephrotoxicity of S-(2-chloro-1,1,2-trifluoroethyl)glutathione and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine, the glutathione and cysteine conjugates of chlorotrifluoroethene. , 1985, The Journal of pharmacology and experimental therapeutics.

[8]  E. Lock,et al.  Effect of the organic acid transport inhibitor probenecid on renal cortical uptake and proximal tubular toxicity of hexachloro-1,3-butadiene and its conjugates. , 1985, Toxicology and applied pharmacology.

[9]  M. W. Anders,et al.  Renal processing of glutathione conjugates. Role in nephrotoxicity. , 1984, Biochemical pharmacology.

[10]  J. Odum,et al.  The metabolism and nephrotoxicity of tetrafluoroethylene in the rat. , 1984, Toxicology and applied pharmacology.

[11]  F. Guengerich,et al.  Glutathione-mediated binding of dibromoalkanes to DNA: specificity of rat glutathione-S-transferases and dibromoalkane structure. , 1984, Carcinogenesis.

[12]  E. Lock,et al.  The metabolism and disposition of hexachloro-1:3-butadiene in the rat and its relevance to nephrotoxicity. , 1984, Toxicology and applied pharmacology.

[13]  A. J. Gandolfi,et al.  In vivo and in vitro nephrotoxicity of the cysteine conjugate of hexachlorobutadiene. , 1983, Journal of toxicology and environmental health.

[14]  B. Ames,et al.  Revised methods for the Salmonella mutagenicity test. , 1983, Mutation research.

[15]  M. W. Anders,et al.  The enzymatic reaction of chlorotrifluoroethylene with glutathione. , 1982, Biochemical and biophysical research communications.

[16]  M. Tateishi,et al.  Purification and characterization of a rat liver enzyme catalyzing N-deacetylation of mercapturic acid conjugates. , 1981, Drug metabolism and disposition: the biological fate of chemicals.

[17]  N. Curthoys,et al.  The absolute asymmetry of orientation of gamma-glutamyltranspeptidase and aminopeptidase on the external surface of the rat renal brush border membrane. , 1980, Journal of Biological Chemistry.

[18]  P. van Bladeren,et al.  Stereoselective activation of vicinal dihalogen compounds to mutagens by glutathione conjugation. , 1979, Biochemical pharmacology.

[19]  T. Shih,et al.  Macromolecular binding and metabolism of the carcinogen 1,2-dibromoethane. , 1978, Cancer research.

[20]  S. Schütz,et al.  Mutagenicity of the mercapturic acid and other S-containing derivatives of hexachloro-1,3-butadiene. , 1986, Carcinogenesis.

[21]  J. Odum,et al.  Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chlgro and fluoroalkenes , 1985 .

[22]  E. Lock,et al.  Role of microsomal and cytosolic glutathione S-transferases in the conjugation of hexachloro-1:3-butadiene and its possible relevance to toxicity. , 1984, The Journal of pharmacology and experimental therapeutics.

[23]  L. F. Chasseaud,et al.  The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents. , 1979, Advances in cancer research.

[24]  U. Rannug,et al.  The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium I. Activation through conjugation with glutathion in vitro. , 1978, Chemico-biological interactions.