A DNA Hypomethylating Drug Alters the Tumor Microenvironment and Improves the Effectiveness of Immune Checkpoint Inhibitors in a Mouse Model of Pancreatic Cancer
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B. Tycko | C. Drake | K. Olive | T. Wang | R. Takahashi | T. Gonda | Martha Salas | G. Manji | E. Hsu | A. Zhukovskaya | Zoila A. Lopez-Bujanda | Catherine Do | Jarwei Fang | Ariel Siegel
[1] R. Fields,et al. Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies , 2019, Science Translational Medicine.
[2] C. Iacobuzio-Donahue,et al. Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer , 2019, Proceedings of the National Academy of Sciences.
[3] B. El-Rayes,et al. Pancreatic Cancer and Immunotherapy: Resistance Mechanisms and Proposed Solutions , 2018, Journal of Gastrointestinal Cancer.
[4] A. Ferguson-Smith,et al. Identification, Characterization, and Heritability of Murine Metastable Epialleles: Implications for Non-genetic Inheritance , 2018, Cell.
[5] A. Welm,et al. Inhibition of RON kinase potentiates anti-CTLA-4 immunotherapy to shrink breast tumors and prevent metastatic outgrowth , 2018, Oncoimmunology.
[6] Asha Nair,et al. Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes , 2018, Nature Communications.
[7] C. Zahnow,et al. Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden , 2017, Proceedings of the National Academy of Sciences.
[8] C. Zahnow,et al. Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer , 2017, Cell.
[9] Chunsheng Zhang,et al. Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. , 2017, Cancer cell.
[10] A. Maitra,et al. The role of stromal cancer-associated fibroblasts in pancreatic cancer , 2017, Journal of Hematology & Oncology.
[11] T. Oyama,et al. Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages , 2016, Oncotarget.
[12] W. Ge,et al. Elevated YKL-40 expression is associated with a poor prognosis in breast cancer patients , 2016, Oncotarget.
[13] B. Stanger,et al. Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer , 2016, Clinical Cancer Research.
[14] V. Ellenrieder,et al. Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon? , 2016, Gut.
[15] Michael C. Ostrowski,et al. IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer , 2016, Gut.
[16] A. Maitra,et al. Exploiting the neoantigen landscape for immunotherapy of pancreatic ductal adenocarcinoma , 2016, Scientific Reports.
[17] S. Pandol,et al. Macrophages and pancreatic ductal adenocarcinoma. , 2016, Cancer letters.
[18] Y. Shentu,et al. Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer. , 2016, The New England journal of medicine.
[19] Michael C. Ostrowski,et al. Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia1 , 2016, Neoplasia.
[20] M. Pasca di Magliano,et al. Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer , 2016, Gut.
[21] Christopher Malcuit,et al. Macrophage‐Associated Osteoactivin/GPNMB Mediates Mesenchymal Stem Cell Survival, Proliferation, and Migration Via a CD44‐Dependent Mechanism , 2016, Journal of cellular biochemistry.
[22] A. Biankin,et al. CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma , 2016, Cancer cell.
[23] Sarah I. Alothman,et al. Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice. , 2016, Gastroenterology.
[24] D. Weaver,et al. Targeting Focal Adhesion Kinase Renders Pancreatic Cancers Responsive to Checkpoint Immunotherapy , 2016, Nature Medicine.
[25] A. Dear. Epigenetic Modulators and the New Immunotherapies. , 2016, The New England journal of medicine.
[26] D. Linehan,et al. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. , 2015, Cancer research.
[27] J. Larkin,et al. Pembrolizumab versus Ipilimumab in Advanced Melanoma. , 2015, The New England journal of medicine.
[28] Halli E. Miller,et al. Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses , 2015, Proceedings of the National Academy of Sciences.
[29] K. Rothamel,et al. Gene Expression during the Generation and Activation of Mouse Neutrophils: Implication of Novel Functional and Regulatory Pathways , 2014, PloS one.
[30] J. Liu,et al. Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity , 2014, Proceedings of the National Academy of Sciences.
[31] Lieping Chen,et al. Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity. , 2014, The Journal of clinical investigation.
[32] D. Fearon. The Carcinoma-Associated Fibroblast Expressing Fibroblast Activation Protein and Escape from Immune Surveillance , 2014, Cancer Immunology Research.
[33] P. Greenberg,et al. Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity , 2014, Gut.
[34] Derek S. Chan,et al. Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer , 2013, Proceedings of the National Academy of Sciences.
[35] Charles C. Kim,et al. Beyond the transcriptome: completion of act one of the Immunological Genome Project. , 2013, Current opinion in immunology.
[36] C. Jacobi,et al. Induction of M2-macrophages by tumour cells and tumour growth promotion by M2-macrophages: a quid pro quo in pancreatic cancer. , 2013, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
[37] S. Gordon,et al. Tissue macrophage heterogeneity: issues and prospects , 2013, Seminars in Immunopathology.
[38] Ting Gong,et al. DeconRNASeq: a statistical framework for deconvolution of heterogeneous tissue samples based on mRNA-Seq data , 2013, Bioinform..
[39] B. Tycko,et al. Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma. , 2013, Cancer research.
[40] S. Goerdt,et al. The CD20 homolog Ms4a8a integrates pro‐ and anti‐inflammatory signals in novel M2‐like macrophages and is expressed in parasite infection , 2012, European journal of immunology.
[41] S. Goerdt,et al. Differentiation and gene expression profile of tumor-associated macrophages. , 2012, Seminars in cancer biology.
[42] Kevin W Eliceiri,et al. NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.
[43] C. Drake,et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. , 2012, The New England journal of medicine.
[44] N. Jhala,et al. Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. , 2012, Cancer cell.
[45] Yuan Ji,et al. Reduced levels of p15INK4b, p16INK4a, p21cip1 and p27kip1 in pancreatic carcinoma , 2012, Molecular medicine reports.
[46] Lieping Chen,et al. Cutting Edge: A Monoclonal Antibody Specific for the Programmed Death-1 Homolog Prevents Graft-versus-Host Disease in Mouse Models , 2011, The Journal of Immunology.
[47] M. Willart,et al. Persistent activation of dendritic cells after resolution of allergic airway inflammation breaks tolerance to inhaled allergens in mice. , 2011, American journal of respiratory and critical care medicine.
[48] David C. Gondek,et al. VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses , 2011, The Journal of experimental medicine.
[49] A. Mackensen,et al. Suppression of T-cell responses by tumor metabolites , 2011, Cancer Immunology, Immunotherapy.
[50] S. Rosenberg,et al. Phase 2 Trial of Single Agent Ipilimumab (Anti-CTLA-4) for Locally Advanced or Metastatic Pancreatic Adenocarcinoma , 2010, Journal of immunotherapy.
[51] Cole Trapnell,et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. , 2010, Nature biotechnology.
[52] M. Robinson,et al. A scaling normalization method for differential expression analysis of RNA-seq data , 2010, Genome Biology.
[53] David Allard,et al. Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer , 2009, Science.
[54] P. Loke. Faculty Opinions recommendation of Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung. , 2009 .
[55] A. Murphy,et al. Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung , 2009, The Journal of experimental medicine.
[56] D. Hume,et al. Gpnmb Is Induced in Macrophages by IFN-γ and Lipopolysaccharide and Acts as a Feedback Regulator of Proinflammatory Responses1 , 2007, The Journal of Immunology.
[57] M. Azuma,et al. Clinical Significance and Therapeutic Potential of the Programmed Death-1 Ligand/Programmed Death-1 Pathway in Human Pancreatic Cancer , 2007, Clinical Cancer Research.
[58] Paolo Serafini,et al. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. , 2006, The Journal of clinical investigation.
[59] R. Hruban,et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. , 2005, Cancer cell.
[60] Judith E. Allen,et al. Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro. , 2003, Immunology letters.
[61] John S. Welch,et al. TH2 Cytokines and Allergic Challenge Induce Ym1 Expression in Macrophages by a STAT6-dependent Mechanism* , 2002, The Journal of Biological Chemistry.
[62] M. Wills-Karp. Faculty Opinions recommendation of Expression of the Ym2 lectin-binding protein is dependent on interleukin (IL)-4 and IL-13 signal transduction: identification of a novel allergy-associated protein. , 2001 .
[63] J. Liao,et al. Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity. , 2001, Cancer research.