Oxymatrine ameliorates myocardial injury by inhibiting oxidative stress and apoptosis via the Nrf2/HO-1 and JAK/STAT pathways in type 2 diabetic rats

[1]  Zhiwei Huang,et al.  Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis , 2021, Bioengineered.

[2]  Haiyang Yu,et al.  Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment , 2021, Cancer Cell International.

[3]  Xiaomin Kang,et al.  Signaling Pathways Involved in Diabetic Renal Fibrosis , 2021, Frontiers in Cell and Developmental Biology.

[4]  L. Yanan,et al.  Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review , 2021, Frontiers in Pharmacology.

[5]  A. Kappo,et al.  The triterpene, methyl-3β-hydroxylanosta-9,24-dien-21-oate (RA3), attenuates high glucose-induced oxidative damage and apoptosis by improving energy metabolism. , 2021, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[6]  N. Allouche,et al.  Cardiopreventive capacity of a novel (E)‐Nʹ‐(1‐(7‐methoxy‐2‐oxo‐2H‐chromen‐3‐yl) ethylidene)‐4‐methylbenzenesulfonohydrazide against isoproterenol‐induced myocardial infarction by moderating biochemical, oxidative stress, and histological parameters , 2021, Journal of biochemical and molecular toxicology.

[7]  Ning Wang,et al.  Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management , 2021, Acta pharmaceutica Sinica. B.

[8]  Hanwei Chen,et al.  Ozone protects cardiomyocytes against ischemia/reperfusion injury: Regulating the heat shock protein 70 (HSP70) expression through activating the JAK2/STAT3 Pathway , 2021, Bioengineered.

[9]  Xi Zhang,et al.  Oxymatrine Ameliorates Memory Impairment in Diabetic Rats by Regulating Oxidative Stress and Apoptosis: Involvement of NOX2/NOX4 , 2020, Oxidative medicine and cellular longevity.

[10]  Wan-gang Guo,et al.  Bakuchiol Alleviates Hyperglycemia-Induced Diabetic Cardiomyopathy by Reducing Myocardial Oxidative Stress via Activating the SIRT1/Nrf2 Signaling Pathway , 2020, Oxidative medicine and cellular longevity.

[11]  A. Śliwińska,et al.  The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress , 2020, International journal of molecular sciences.

[12]  Zhinan Mei,et al.  Oxymatrine ameliorates Imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes. , 2020, Toxicology and applied pharmacology.

[13]  C. Chien,et al.  Diabetes Upregulates Oxidative Stress and Downregulates Cardiac Protection to Exacerbate Myocardial Ischemia/Reperfusion Injury in Rats , 2020, Antioxidants.

[14]  D. Bers,et al.  Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O-linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes , 2020, Circulation research.

[15]  P. Moore,et al.  Induction of caveolin-3/eNOS complex by nitroxyl (HNO) ameliorates diabetic cardiomyopathy , 2020, Redox biology.

[16]  Laichun Song,et al.  Baicalin regulates macrophages polarization and alleviates myocardial ischaemia/reperfusion injury via inhibiting JAK/STAT pathway , 2020, Pharmaceutical biology.

[17]  C. Cheung,et al.  Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats , 2019, Journal of cellular and molecular medicine.

[18]  T. Guzik,et al.  Oxidative stress and inflammatory markers in prediabetes and diabetes. , 2019, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[19]  Yue Liu,et al.  Oxymatrine Exerts Organ- and Tissue-Protective Effects by Regulating Inflammation, Oxidative Stress, Apoptosis, and Fibrosis: From Bench to Bedside. , 2019, Pharmacological research.

[20]  Jingyao Zhang,et al.  Methane Alleviates Acetaminophen-Induced Liver Injury by Inhibiting Inflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Apoptosis through the Nrf2/HO-1/NQO1 Signaling Pathway , 2019, Oxidative medicine and cellular longevity.

[21]  Zhanghua Wu,et al.  IL6R inhibits viability and apoptosis of pancreatic beta-cells in type 2 diabetes mellitus via regulation by miR-22 of the JAK/STAT signaling pathway , 2019, Diabetes, metabolic syndrome and obesity : targets and therapy.

[22]  R. Selgas,et al.  Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition , 2019, Front. Pharmacol..

[23]  Sahar A. Khaleel,et al.  Curcumin augments the cardioprotective effect of metformin in an experimental model of type I diabetes mellitus; Impact of Nrf2/HO-1 and JAK/STAT pathways. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[24]  G. Sethi,et al.  Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model , 2019, Cancers.

[25]  Q. Ma,et al.  Oxymatrine ameliorates diabetes‐induced aortic endothelial dysfunction via the regulation of eNOS and NOX4 , 2018, Journal of cellular biochemistry.

[26]  T. Lüscher,et al.  Hyperglycaemia-induced epigenetic changes drive persistent cardiac dysfunction via the adaptor p66Shc. , 2018, International journal of cardiology.

[27]  T. Yi,et al.  NF-κB-Gasdermin D (GSDMD) Axis Couples Oxidative Stress and NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3) Inflammasome-Mediated Cardiomyocyte Pyroptosis Following Myocardial Infarction , 2018, Medical science monitor : international medical journal of experimental and clinical research.

[28]  Hui Liu,et al.  Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway , 2018, International journal of immunopathology and pharmacology.

[29]  Hala A. Attia,et al.  Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3β and p38α/MAPK in a rat model of diabetic cardiomyopathy. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[30]  Tao Zhang,et al.  Oxymatrine exerts protective effects on osteoarthritis via modulating chondrocyte homoeostasis and suppressing osteoclastogenesis , 2018, Journal of cellular and molecular medicine.

[31]  Bo Zhao,et al.  The Roles of Autophagy in Acute Lung Injury Induced by Myocardial Ischemia Reperfusion in Diabetic Rats , 2018, Journal of diabetes research.

[32]  2018 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference , 2018, Journal of Clinical Immunology.

[33]  Jian Yang,et al.  Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway , 2018, Oxidative medicine and cellular longevity.

[34]  J. D. de Haan,et al.  Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications , 2018, Front. Physiol..

[35]  Bassant M Barakat,et al.  Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway , 2018, Oxidative medicine and cellular longevity.

[36]  Lifang Yang,et al.  Insights for Oxidative Stress and mTOR Signaling in Myocardial Ischemia/Reperfusion Injury under Diabetes , 2017, Oxidative medicine and cellular longevity.

[37]  R. Stocker,et al.  Heme Oxygenases in Cardiovascular Health and Disease. , 2016, Physiological reviews.

[38]  Bo Zhao,et al.  Overexpression of DJ-1 reduces oxidative stress and attenuates hypoxia/reoxygenation injury in NRK-52E cells exposed to high glucose , 2016, International journal of molecular medicine.

[39]  J. Scholey,et al.  Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus. , 2016, Journal of molecular and cellular cardiology.

[40]  P. Kamble,et al.  Heme oxygenase-1, a novel target for the treatment of diabetic complications: focus on diabetic peripheral neuropathy. , 2015, Pharmacological research.

[41]  Hui Chen,et al.  Oxymatrine ameliorates renal ischemia-reperfusion injury from oxidative stress through Nrf2/HO-1 pathway. , 2015, Acta cirurgica brasileira.

[42]  F. Santilli,et al.  Oxidative stress-related mechanisms affecting response to aspirin in diabetes mellitus. , 2015, Free radical biology & medicine.

[43]  Aileen J F King,et al.  The use of animal models in diabetes research , 2012, British journal of pharmacology.

[44]  H. Drexler,et al.  The myocardial JAK/STAT pathway: from protection to failure. , 2008, Pharmacology & therapeutics.

[45]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[46]  J. Sowers,et al.  Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease , 2017, Diabetologia.

[47]  D. Bell,et al.  Diabetic cardiomyopathy. , 2003, Diabetes care.

[48]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[49]  Thomas D. Schmittgen,et al.  Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 2 DD C T Method , 2022 .