What does endotyping mean for treatment in chronic obstructive pulmonary disease?
暂无分享,去创建一个
[1] Richard Beasley,et al. After asthma: redefining airways diseases , 2017, The Lancet.
[2] Lisa Rosenbaum,et al. Bridging the Data-Sharing Divide - Seeing the Devil in the Details, Not the Other Camp. , 2017, The New England journal of medicine.
[3] M. Obeidat,et al. Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease , 2017, Respiratory Research.
[4] C. Manichanh,et al. The microbiome in respiratory medicine: current challenges and future perspectives , 2017, European Respiratory Journal.
[5] Meilan K. Han,et al. Chronic Respiratory Symptoms with Normal Spirometry. A Reliable Clinical Entity? , 2017, American journal of respiratory and critical care medicine.
[6] A. Bush. Lung Development and Aging. , 2016, Annals of the American Thoracic Society.
[7] A. Agustí,et al. Multilevel, Dynamic Chronic Obstructive Pulmonary Disease Heterogeneity. A Challenge for Personalized Medicine. , 2016, Annals of the American Thoracic Society.
[8] Jesper Tegnér,et al. From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration , 2016, BMC Bioinformatics.
[9] Ivana V. Yang,et al. Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. , 2016, American journal of respiratory and critical care medicine.
[10] F. Martinez. Early-Life Origins of Chronic Obstructive Pulmonary Disease. , 2016, The New England journal of medicine.
[11] R. Rodríguez-Roisín,et al. Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema. , 2016, American journal of respiratory and critical care medicine.
[12] L. Fabbri. Smoking, Not COPD, as the Disease. , 2016, The New England journal of medicine.
[13] I. Pavord,et al. Treatable traits: toward precision medicine of chronic airway diseases , 2016, European Respiratory Journal.
[14] A. Agustí,et al. Biomarkers, the control panel and personalized COPD medicine , 2016, Respirology.
[15] B. Celli,et al. B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease. , 2015, American journal of respiratory and critical care medicine.
[16] Ferran Sanz,et al. Molecular and clinical diseasome of comorbidities in exacerbated COPD patients , 2015, European Respiratory Journal.
[17] Berend C Stoel,et al. Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial , 2015, The Lancet.
[18] J. Soriano,et al. Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease. , 2015, The New England journal of medicine.
[19] D. Longo,et al. Precision medicine--personalized, problematic, and promising. , 2015, The New England journal of medicine.
[20] I. Pavord,et al. Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials. , 2015, The Lancet. Respiratory medicine.
[21] A. Barabasi,et al. A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma. , 2015, Human molecular genetics.
[22] A. Agustí,et al. Drug development for airway diseases: looking forward , 2015, Nature Reviews Drug Discovery.
[23] F. Martinez,et al. Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management , 2015, The Lancet.
[24] N. Schork. Personalized medicine: Time for one-person trials , 2015, Nature.
[25] Albert-László Barabási,et al. A DIseAse MOdule Detection (DIAMOnD) Algorithm Derived from a Systematic Analysis of Connectivity Patterns of Disease Proteins in the Human Interactome , 2015, PLoS Comput. Biol..
[26] F. Collins,et al. A new initiative on precision medicine. , 2015, The New England journal of medicine.
[27] A. Barabasi,et al. Uncovering disease-disease relationships through the incomplete interactome , 2015, Science.
[28] C. Auffray,et al. Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014. , 2015, American journal of respiratory and critical care medicine.
[29] Martin Hofmann-Apitius,et al. Towards the taxonomy of human disease , 2015, Nature Reviews Drug Discovery.
[30] Weiliang Qiu,et al. Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods , 2015, BMC Medical Genomics.
[31] E. Bleecker,et al. Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: a randomised, double-blind, placebo-controlled, phase 2a study. , 2014, The Lancet. Respiratory medicine.
[32] Frederick B. Marcus,et al. A systems medicine clinical platform for understanding and managing non- communicable diseases. , 2014, Current pharmaceutical design.
[33] Craig E Wheelock,et al. Network analysis in the investigation of chronic respiratory diseases. From basics to application. , 2014, American journal of respiratory and critical care medicine.
[34] Pablo Villoslada,et al. Modules, networks and systems medicine for understanding disease and aiding diagnosis , 2014, Genome Medicine.
[35] J. Roca,et al. Network medicine analysis of COPD multimorbidities , 2014, Respiratory Research.
[36] Tudor I. Oprea,et al. Temporal disease trajectories condensed from population-wide registry data covering 6.2 million patients , 2014, Nature Communications.
[37] Meilan K. Han,et al. Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy. , 2014, American journal of respiratory and critical care medicine.
[38] Martine Vrijheid,et al. The exposome: a new paradigm to study the impact of environment on health , 2014, Thorax.
[39] A. Agustí,et al. Systemic Inflammatory Response to Smoking in Chronic Obstructive Pulmonary Disease: Evidence of a Gender Effect , 2014, PloS one.
[40] A. Agustí. The path to personalised medicine in COPD , 2014, Thorax.
[41] Albert-László Barabási,et al. A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in Chronic Obstructive Pulmonary Disease , 2014, BMC Systems Biology.
[42] Meilan K. Han,et al. Tumour necrosis factor receptor-75 and risk of COPD exacerbation in the azithromycin trial , 2013, European Respiratory Journal.
[43] A. Agustí,et al. Immune response in chronic obstructive pulmonary disease , 2013, Expert review of clinical immunology.
[44] I. Pavord,et al. Moving from the Oslerian paradigm to the post-genomic era: are asthma and COPD outdated terms? , 2013, Thorax.
[45] B. Beghé,et al. Exacerbation of respiratory symptoms in COPD patients may not be exacerbations of COPD , 2013, European Respiratory Journal.
[46] L. Wood,et al. Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense? , 2013, Thorax.
[47] F. Martinez,et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. , 2007, American journal of respiratory and critical care medicine.
[48] Alvar Agusti,et al. The COPD control panel: towards personalised medicine in COPD , 2012, Thorax.
[49] Christopher E Brightling,et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. , 2012, American journal of respiratory and critical care medicine.
[50] Courtney Crim,et al. Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype , 2012, PloS one.
[51] P. Sorger,et al. Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks , 2012, Cell.
[52] C. Wild,et al. The exposome: from concept to utility. , 2012, International journal of epidemiology.
[53] H. Kitano,et al. Software for systems biology: from tools to integrated platforms , 2011, Nature Reviews Genetics.
[54] A. Barabasi,et al. Systems biology and the future of medicine , 2011, Wiley interdisciplinary reviews. Systems biology and medicine.
[55] Christopher E Brightling,et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. , 2011, American journal of respiratory and critical care medicine.
[56] I. Kola,et al. A call to reform the taxonomy of human disease , 2011, Nature Reviews Drug Discovery.
[57] John Connett,et al. Azithromycin for prevention of exacerbations of COPD. , 2011, The New England journal of medicine.
[58] B. Celli,et al. Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine. , 2011, American journal of respiratory and critical care medicine.
[59] Adnan Custovic,et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. , 2011, The Journal of allergy and clinical immunology.
[60] I. Pavord,et al. Acute Exacerbations of COPD: Identification of Biological Clusters and Their Biomarkers , 2011 .
[61] J. Wedzicha,et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. , 2010, The New England journal of medicine.
[62] D. Noble,et al. Systems Biology: An Approach , 2010, Clinical pharmacology and therapeutics.
[63] A. Barabasi,et al. Network medicine : a network-based approach to human disease , 2010 .
[64] Alvar Agusti,et al. Immunologic aspects of chronic obstructive pulmonary disease. , 2009, The New England journal of medicine.
[65] S. Salvi,et al. Chronic obstructive pulmonary disease in non-smokers , 2009, The Lancet.
[66] D. Mannino,et al. The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort. , 2009, American journal of respiratory and critical care medicine.
[67] Albert-László Barabási,et al. A Dynamic Network Approach for the Study of Human Phenotypes , 2009, PLoS Comput. Biol..
[68] D. Mannino,et al. Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD , 2008, European Respiratory Journal.
[69] F. Sciurba,et al. Autoantibodies in patients with chronic obstructive pulmonary disease. , 2008, American journal of respiratory and critical care medicine.
[70] K. Rabe,et al. From COPD to chronic systemic inflammatory syndrome? , 2007, The Lancet.
[71] A. Barabasi,et al. Network medicine--from obesity to the "diseasome". , 2007, The New England journal of medicine.
[72] A. Barabasi,et al. Human disease classification in the postgenomic era: A complex systems approach to human pathobiology , 2007, Molecular systems biology.
[73] A. Barabasi,et al. The human disease network , 2007, Proceedings of the National Academy of Sciences.
[74] I. Pavord,et al. Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial , 2007, European Respiratory Journal.
[75] H. Coxson,et al. Antielastin autoimmunity in tobacco smoking–induced emphysema , 2007, Nature Medicine.
[76] S. Biswal,et al. Role of lung maintenance program in the heterogeneity of lung destruction in emphysema. , 2006, Proceedings of the American Thoracic Society.
[77] P. Jones,et al. Outcomes and markers in the assessment of chronic obstructive pulmonary disease , 2006, European Respiratory Journal.
[78] I. Adcock,et al. Epigenetics and airways disease , 2006, Respiratory research.
[79] I. Pavord,et al. Multi‐dimensional phenotyping: towards a new taxonomy for airway disease , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[80] I. Pavord,et al. Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease , 2005, Thorax.
[81] X. Busquets,et al. Systemic effects of chronic obstructive pulmonary disease , 2003, European Respiratory Journal.
[82] H. Kitano,et al. Computational systems biology , 2002, Nature.
[83] H. Kitano. Systems Biology: A Brief Overview , 2002, Science.
[84] Hiroaki Kitano,et al. Foundations of systems biology , 2001 .
[85] I. Pavord,et al. Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial , 2000, The Lancet.
[86] Farid Neema,et al. Data sharing , 1998 .
[87] P. J. Barnes,et al. Increased nitric oxide in exhaled air of asthmatic patients , 1994, The Lancet.
[88] J. Scadding,et al. Health and disease: what can medicine do for philosophy? , 1988, Journal of medical ethics.
[89] R. Peto,et al. The natural history of chronic airflow obstruction. , 1977, British medical journal.
[90] C. Laurell. Is emphysema in alpha 1 -antitrypsin deficiency a result of autodigestion? , 1971, Scandinavian journal of clinical and laboratory investigation.
[91] G. Turino,et al. Serum Elastase Inhibitor Deficiency and αl-Antitrypsin Deficiency in Patients with Obstructive Emphysema , 1969, Science.
[92] C. Laurell,et al. Obstructive Lung Disease and Trypsin Inhibitors in α1-Antitrypsin Deficiency , 1967 .