Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

[1]  Dylan S. Small,et al.  Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score , 2018, The Annals of Statistics.

[2]  Stephen Burgess,et al.  PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations , 2019, Bioinform..

[3]  D M Parkin,et al.  Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods , 2018, International journal of cancer.

[4]  Benjamin B. Sun,et al.  New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. , 2018, Nature Genetics.

[5]  K. D. Sørensen,et al.  Shared heritability and functional enrichment across six solid cancers , 2019, Nature Communications.

[6]  M. Oudkerk,et al.  PL02.05 Effects of Volume CT Lung Cancer Screening: Mortality Results of the NELSON Randomised-Controlled Population Based Trial , 2018, Journal of Thoracic Oncology.

[7]  P. Donnelly,et al.  The UK Biobank resource with deep phenotyping and genomic data , 2018, Nature.

[8]  Christian Gieger,et al.  Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease , 2018, Nature Communications.

[9]  A. Price,et al.  Functional architecture of low-frequency variants highlights strength of negative selection across coding and noncoding annotations , 2018, Nature Genetics.

[10]  Lauren S. Mogil,et al.  Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function , 2018, Nature Communications.

[11]  G. Kollias,et al.  Cigarette Smoke–Induced Emphysema Exhausts Early Cytotoxic CD8+ T Cell Responses against Nascent Lung Cancer Cells , 2018, The Journal of Immunology.

[12]  D. Lawlor,et al.  Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption , 2018, bioRxiv.

[13]  Donna D. Zhang,et al.  NRF2 and the Hallmarks of Cancer. , 2018, Cancer cell.

[14]  A. Malik,et al.  Mechanosensing Piezo channels in tissue homeostasis including their role in lungs , 2018, Pulmonary circulation.

[15]  Stephen Burgess,et al.  Genomic atlas of the human plasma proteome , 2018, Nature.

[16]  S. Burgess,et al.  Contextualizing selection bias in Mendelian randomization: how bad is it likely to be? , 2018, International journal of epidemiology.

[17]  D. Raychaudhuri,et al.  Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation , 2018, The Journal of Immunology.

[18]  G. Davey Smith,et al.  Orienting the causal relationship between imprecisely measured traits using GWAS summary data , 2017, PLoS genetics.

[19]  J. Grandl,et al.  Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels. , 2017, Cell reports.

[20]  William S. Bush,et al.  Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes , 2017, Nature Genetics.

[21]  J. Rosenblatt,et al.  Mechanical stretch triggers rapid epithelial cell division through Piezo1 , 2017, Nature.

[22]  N. Sheehan,et al.  A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization , 2017, Statistics in medicine.

[23]  B. Neale,et al.  Linkage disequilibrium dependent architecture of human complex traits reveals action of negative selection , 2016, bioRxiv.

[24]  D. Hougaard,et al.  Genome-wide association study identifies variants in HORMAD2 associated with tonsillectomy , 2016, Journal of Medical Genetics.

[25]  G. Davey Smith,et al.  Response to Hartwig and Davies , 2016, International Journal of Epidemiology.

[26]  N. Sheehan,et al.  Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic , 2016, International journal of epidemiology.

[27]  Stephen Burgess,et al.  PhenoScanner: a database of human genotype–phenotype associations , 2016, Bioinform..

[28]  Shane A. McCarthy,et al.  An organelle-specific protein landscape identifies novel diseases and molecular mechanisms , 2016, Nature Communications.

[29]  E. Xing,et al.  Gene expression profiling of asthma phenotypes demonstrates molecular signatures of atopy and asthma control. , 2016, The Journal of allergy and clinical immunology.

[30]  G. Davey Smith,et al.  Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator , 2016, Genetic epidemiology.

[31]  Guangchuang Yu,et al.  ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization. , 2016, Molecular bioSystems.

[32]  S. Lam,et al.  Macrophages, Inflammation, and Lung Cancer. , 2016, American journal of respiratory and critical care medicine.

[33]  Pablo Tamayo,et al.  Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation. , 2016, Immunity.

[34]  I. Adcock,et al.  The relationship between COPD and lung cancer , 2015, Lung cancer.

[35]  Yakir A Reshef,et al.  Partitioning heritability by functional annotation using genome-wide association summary statistics , 2015, Nature Genetics.

[36]  Ross M. Fraser,et al.  Genetic studies of body mass index yield new insights for obesity biology , 2015, Nature.

[37]  Peter Kraft,et al.  Adjusting for heritable covariates can bias effect estimates in genome-wide association studies. , 2015, American journal of human genetics.

[38]  Michael Q. Zhang,et al.  Integrative analysis of 111 reference human epigenomes , 2015, Nature.

[39]  M. Daly,et al.  LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.

[40]  S. Dubinett Inflammation and Lung Cancer , 2015, Springer New York.

[41]  K. Straif,et al.  Is previous respiratory disease a risk factor for lung cancer? , 2014, American journal of respiratory and critical care medicine.

[42]  N. Yuldasheva,et al.  Piezo1 integration of vascular architecture with physiological force , 2014, Nature.

[43]  R. Zhai,et al.  Smoking and smoking cessation in relation to the development of co‐existing non‐small cell lung cancer with chronic obstructive pulmonary disease , 2014, International journal of cancer.

[44]  M. Ebina,et al.  Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function , 2013, The Journal of experimental medicine.

[45]  K. Fong,et al.  Genetic susceptibility to lung cancer and co-morbidities. , 2013, Journal of thoracic disease.

[46]  A. Butterworth,et al.  Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data , 2013, Genetic epidemiology.

[47]  T. Graeber,et al.  BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint , 2013, Nature Medicine.

[48]  Ivan Limongelli,et al.  Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1. , 2013, Blood.

[49]  A. M. Houghton,et al.  Mechanistic links between COPD and lung cancer , 2013, Nature Reviews Cancer.

[50]  David C. Nickle,et al.  Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma , 2012, PLoS genetics.

[51]  P. Lee,et al.  Systematic review with meta-analysis of the epidemiological evidence relating FEV1 decline to lung cancer risk , 2012, BMC Cancer.

[52]  H. Morgenstern,et al.  Systematic Reviews and Meta-and Pooled Analyses Previous Lung Diseases and Lung Cancer Risk : A Pooled Analysis From the International Lung Cancer Consortium , 2012 .

[53]  D. Postma,et al.  NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. , 2012, Physiological genomics.

[54]  M. Sporn,et al.  NRF2 and cancer: the good, the bad and the importance of context , 2012, Nature Reviews Cancer.

[55]  Tim Peakman,et al.  New Models for Large Prospective Studies: Is There a Better Way? , 2012, American journal of epidemiology.

[56]  C. Gatsonis,et al.  Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening , 2012 .

[57]  Chi-Ying F. Huang,et al.  The Novel Protein Suppressed in Lung Cancer Down-Regulated in Lung Cancer Tissues Retards Cell Proliferation and Inhibits the Oncokinase Aurora-A , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[58]  Darren R. Brenner,et al.  Previous Lung Diseases and Lung Cancer Risk: A Systematic Review and Meta-Analysis , 2011, PloS one.

[59]  G. Gamble,et al.  Chromosome 4q31 locus in COPD is also associated with lung cancer , 2010, European Respiratory Journal.

[60]  Tariq Ahmad,et al.  Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci , 2010, Nature Genetics.

[61]  Josyf Mychaleckyj,et al.  Robust relationship inference in genome-wide association studies , 2010, Bioinform..

[62]  Ming D. Li,et al.  Genome-wide meta-analyses identify multiple loci associated with smoking behavior , 2010, Nature Genetics.

[63]  A. Hofman,et al.  Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function , 2010, Nature Genetics.

[64]  Johan Van Limbergen,et al.  Common variants at five new loci associated with early-onset inflammatory bowel disease , 2009, Nature Genetics.

[65]  C. la Vecchia,et al.  Lung function predicts lung cancer risk in smokers: a tool for targeting screening programmes , 2009, European Respiratory Journal.

[66]  P. Green,et al.  Widespread Genomic Signatures of Natural Selection in Hominid Evolution , 2009, PLoS genetics.

[67]  P. Metcalf,et al.  COPD prevalence is increased in lung cancer, independent of age, sex and smoking history , 2009, European Respiratory Journal.

[68]  J. Leader,et al.  Association of radiographic emphysema and airflow obstruction with lung cancer. , 2008, American journal of respiratory and critical care medicine.

[69]  G. Watts,et al.  UK universities offer degrees in “pseudoscience,” Nature article says , 2007, British medical journal.

[70]  M. Katoh,et al.  Hedgehog signaling pathway and gastric cancer , 2005, Cancer biology & therapy.

[71]  D. Haussler,et al.  Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. , 2005, Genome research.

[72]  J. Hankinson,et al.  Standardisation of spirometry , 2005, European Respiratory Journal.

[73]  P. Paré,et al.  Relationship between reduced forced expiratory volume in one second and the risk of lung cancer: a systematic review and meta-analysis , 2005, Thorax.

[74]  D. Corry,et al.  An Immune Basis for Lung Parenchymal Destruction in Chronic Obstructive Pulmonary Disease and Emphysema , 2004, PLoS medicine.

[75]  D. Mannino,et al.  Low lung function and incident lung cancer in the United States: data From the First National Health and Nutrition Examination Survey follow-up. , 2003, Archives of internal medicine.

[76]  J. Lotem,et al.  Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[77]  H. Birnboim,et al.  Expression of interleukin-8 promotes neutrophil infiltration and genetic instability in mutatect tumors. , 2000, Neoplasia.