Elevated levels of 1‐hydroxypyrene and N′‐nitrosonornicotine in smokers with head and neck cancer: A matched control study

Head and neck squamous cell carcinoma (HNSCC) is associated with tobacco use. Still, most smokers do not develop HNSCC. The mechanisms of varying susceptibility to HNSCC are poorly studied to date. Tobacco metabolite research provides insight regarding the innate metabolism and excretion of carcinogens.

[1]  M. Malcangio,et al.  The role of glia in the spinal cord in neuropathic and inflammatory pain. , 2015, Handbook of experimental pharmacology.

[2]  Jian-Min Yuan,et al.  Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers. , 2011, Carcinogenesis.

[3]  S. Hecht,et al.  Quantitation of a minor enantiomer of phenanthrene tetraol in human urine: correlations with levels of overall phenanthrene tetraol, benzo[a]pyrene tetraol, and 1-hydroxypyrene. , 2011, Chemical research in toxicology.

[4]  P. Delvenne,et al.  Immune Suppression in Head and Neck Cancers: A Review , 2011, Clinical & developmental immunology.

[5]  Jian-Min Yuan,et al.  Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention. , 2010, Chemical research in toxicology.

[6]  S. Burchiel,et al.  Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures. , 2010, IARC monographs on the evaluation of carcinogenic risks to humans.

[7]  A. Malarcher,et al.  Cigarette smoking among adults and trends in smoking cessation - United States, 2008. , 2009, MMWR. Morbidity and mortality weekly report.

[8]  B. Lindgren,et al.  Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products. , 2009, Cancer research.

[9]  Jian-Min Yuan,et al.  Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers. , 2009, Cancer research.

[10]  D. Hatsukami,et al.  Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers. , 2009, Chemical research in toxicology.

[11]  T. Church,et al.  A Prospectively Measured Serum Biomarker for a Tobacco-Specific Carcinogen and Lung Cancer in Smokers , 2009, Cancer Epidemiology Biomarkers & Prevention.

[12]  S. Hecht,et al.  Detection and Quantitation of N′-Nitrosonornicotine in Human Toenails by Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry , 2008, Cancer Epidemiology Biomarkers & Prevention.

[13]  S. Hecht,et al.  Endogenous formation of N'-nitrosonornicotine in F344 rats in the presence of some antioxidants and grape seed extract. , 2007, Journal of agricultural and food chemistry.

[14]  C. Husten,et al.  Tobacco use among adults--United States, 2005. , 2006, MMWR. Morbidity and mortality weekly report.

[15]  S. Hecht,et al.  Tobacco-Specific Nitrosamines and Their Pyridine-N-glucuronides in the Urine of Smokers and Smokeless Tobacco Users , 2005, Cancer Epidemiology Biomarkers & Prevention.

[16]  M. Spitz,et al.  Descriptive epidemiology and risk factors for head and neck cancer. , 2004, Seminars in oncology.

[17]  S. Hecht,et al.  Improved method for determination of 1-hydroxypyrene in human urine. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[18]  M. Thun,et al.  Tobacco smoke and involuntary smoking. , 2004, IARC monographs on the evaluation of carcinogenic risks to humans.

[19]  S. Hecht,et al.  Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[20]  Stephen S. Hecht,et al.  Tobacco carcinogens, their biomarkers and tobacco-induced cancer , 2003, Nature Reviews Cancer.

[21]  Alicia Samuels,et al.  Cancer Statistics, 2003 , 2003, CA: a cancer journal for clinicians.

[22]  S. Hecht,et al.  Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer. , 2002, Carcinogenesis.

[23]  S. Hecht,et al.  Analysis of N- and O-glucuronides of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine. , 2002, Chemical research in toxicology.

[24]  L. Hagmar,et al.  CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure. , 2000, Carcinogenesis.

[25]  P. Wertz,et al.  Penetration of N-nitrosonornicotine (NNN) across oral mucosa in the presence of ethanol and nicotine. , 2000, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[26]  J. Pintos,et al.  Effect of smoking cessation and tobacco type on the risk of cancers of the upper aero-digestive tract in Brazil. , 1999, Epidemiology.

[27]  S. Hecht,et al.  Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. , 1998, Chemical research in toxicology.

[28]  H Schultz,et al.  Tobacco or health: A global status report. , 1998, Annals of Saudi medicine.

[29]  R Doll,et al.  Mortality from smoking worldwide. , 1996, British medical bulletin.

[30]  S. Hecht,et al.  Intraindividual and interindividual differences in metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers' urine. , 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[31]  W. Blot,et al.  Second cancers following oral and pharyngeal cancers: role of tobacco and alcohol. , 1994, Journal of the National Cancer Institute.

[32]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.

[33]  Seymour Reichlin,et al.  Handbook of experimental pharmacology , 1984 .