Dielectric analysis of blood by means of a raster-electrode technique

Dielectric measurements were made on blood samples containing erythrocytes of varying diameter D and percentage p. For effective measurements of the conductivity γ and the dielectric constant ε, in the frequency range f=10–100 kHz electrode effects were corrected by means of a raster-electrode technique, which is based on the automatic variation of the effective electrode area. The results, which proved to be independent of f, indicate that an increase of haematocrit p is linked with a strong decrease of γ, being essentially independent of D. For low and medium p an increase of ε, resulted from increasing p. For physiological values of p close to 40 per cent, a strong increase of ε, was found with increasing D, indicating possibilities of using the method for rapid determination of D in addition to p. For very high values of p (>60 per cent) ε, showed a distinct decrease. This finding is discussed using a cube model for the particle suspension.

[1]  A. Neureuther,et al.  Electron-beam resist edge profile simulation , 1979, IEEE Transactions on Electron Devices.

[2]  Frewer Ra,et al.  The electrical conductivity of flowing blood. , 1974 .

[3]  Hiroshi Kanai,et al.  Electrical Characteristics of Flowing Blood , 1979, IEEE Transactions on Biomedical Engineering.

[4]  A. Oosterom,et al.  Electrical properties of platinum electrodes: Impedance measurements and time-domain analysis , 2006, Medical and Biological Engineering and Computing.

[5]  L. Geddes,et al.  The specific resistance of canine blood at body temperature. , 1973, IEEE transactions on bio-medical engineering.

[7]  Anthony M. Dymond,et al.  Characteristics of the Metal-Tissue Interface of Stimulation Electrodes , 1976, IEEE Transactions on Biomedical Engineering.

[8]  H. Pauly,et al.  Über die Impedanz einer Suspension von kugelförmigen Teilchen mit einer Schale , 1959 .

[9]  H. Pauly Über die elektrische Kapazität der Zellmembran und die Leitfähigkeit des Zytoplasmas von Ehrlich-Aszitestumorzellen , 1963 .

[10]  R. Gosling,et al.  Use of electrical conductance measurements in studies of the orientation of microscopic particles in stationary and flowing suspensions , 1973 .

[11]  A. Ehrly,et al.  Aggregation und Desaggregation von Erythrozyten , 1966 .

[12]  B. Bull,et al.  Red Cell Membrane Deformability: an Examination of Two Apparently Disparate Methods of Measurement , 1978 .

[13]  H. Fricke,et al.  A Mathematical Treatment of the Electric Conductivity and Capacity of Disperse Systems I. The Electric Conductivity of a Suspension of Homogeneous Spheroids , 1924 .

[14]  W. Groner,et al.  Characterizing blood cells by biophysical measurements in flow. , 1980, Blood cells.

[15]  L. A. Geddes,et al.  The impedance of stainless-steel electrodes , 1971, Medical and biological engineering.

[16]  Francis A. Gayon,et al.  Electrode and Electrolyte Impedance in the Detection of Bacterial Growth , 1981, IEEE Transactions on Biomedical Engineering.

[17]  Tatsuo Togawa,et al.  Noninvasive Measurement of Hematocrit by Electrical Admittance Plethysmography Technique , 1980, IEEE Transactions on Biomedical Engineering.

[18]  H. Fricke,et al.  A Mathematical Treatment of the Electric Conductivity and Capacity of Disperse Systems ii. The Capacity of a Suspension of Conducting Spheroids Surrounded by a Non-Conducting Membrane for a Current of Low Frequency , 1925 .

[19]  C. W. Smith,et al.  In vivo dielectric spectrometer , 2006, Medical and Biological Engineering and Computing.