Recent synthetic ion channels and pores

[1]  P. Scrimin,et al.  Model membranes: developments in functional micelles and vesicles. , 1999, Current opinion in chemical biology.

[2]  A. Klibanov,et al.  Bactericidal Properties of Flat Surfaces and Nanoparticles Derivatized with Alkylated Polyethylenimines , 2002, Biotechnology progress.

[3]  D. Gross,et al.  pH-Sensitive, cation-selective channels formed by a simple synthetic polyelectrolyte in artificial bilayer membranes , 1996 .

[4]  Alexander M. Klibanov,et al.  Designing surfaces that kill bacteria on contact , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Seong-Ho Shin,et al.  Single-molecule covalent chemistry with spatially separated reactants. , 2003, Angewandte Chemie.

[6]  P. Bandyopadhyay,et al.  An Ion Conductor Derived from Spermine and Cholic Acid , 2000 .

[7]  W. M. Leevy,et al.  Synthetic hydraphile channels of appropriate length kill Escherichia coli. , 2002, Journal of the American Chemical Society.

[8]  S. Matile,et al.  Synthetic multifunctional pores: lessons from rigid-rod β-barrels , 2003 .

[9]  Y. Kobuke.  Artificial ion channels , 1997 .

[10]  Annelise E Barron,et al.  Helical peptoid mimics of lung surfactant protein C. , 2003, Chemistry & biology.

[11]  Bradley D. Smith,et al.  Chloride transport across vesicle and cell membranes by steroid-based receptors. , 2003, Angewandte Chemie.

[12]  B. de Kruijff,et al.  Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. 3. Molecular structure of the polyene antibiotic-cholesterol complexes. , 1974, Biochimica et biophysica acta.

[13]  Adam L. Sisson,et al.  Perturbing the Hofmeister series: a steroid-based anion receptor with preorganised quaternary ammonium and H-bond donor groups. , 2003, Chemical communications.

[14]  D Ranganathan,et al.  Designer hybrid cyclopeptides for membrane ion transport and tubular structures. , 2001, Accounts of chemical research.

[15]  G. Tew,et al.  New poly(phenyleneethynylene)s with cationic, facially amphiphilic structures. , 2002, Journal of the American Chemical Society.

[16]  David H. Thompson,et al.  Phototriggering of liposomal drug delivery systems. , 2001, Advanced drug delivery reviews.

[17]  Stefan Matile,et al.  p-Octiphenyl β-Barrels with Ion Channel and Esterase Activity , 2001 .

[18]  J. Bowie.  Stabilizing membrane proteins. , 2001, Current opinion in structural biology.

[19]  S. Regen,et al.  Fully detachable molecular umbrellas as peptide delivery agents. , 2003, Bioconjugate chemistry.

[20]  S. Futaki.  Arginine-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms. , 2002, International journal of pharmaceutics.

[21]  Jeffery T. Davis,et al.  Chloride transport across lipid bilayers and transmembrane potential induction by an oligophenoxyacetamide. , 2003, Journal of the American Chemical Society.

[22]  P. Bandyopadhyay,et al.  An ion conductor that recognizes osmotically-stressed phospholipid bilayers. , 2002, Journal of the American Chemical Society.

[23]  Horst Vogel,et al.  Immunosensing by a Synthetic Ligand-Gated Ion Channel Financial support from the board of the Swiss Federal Institutes of Technology (SPP Minast, 7.06) is acknowledged. We thank G. Corradin for numerous discussions and J. Lakey for critical reading of the manuscript. , 2001, Angewandte Chemie.

[24]  S. Otto,et al.  Detection of Nonideal Mixing of Phospholipids in Fluid Bilayers , 2000 .

[25]  Juan R. Granja,et al.  Self-Assembling Organic Nanotubes. , 2001, Angewandte Chemie.

[26]  S. Futaki,et al.  Alamethicin-leucine zipper hybrid peptide: a prototype for the design of artificial receptors and ion channels. , 2001, Journal of the American Chemical Society.

[27]  A. Asokan,et al.  Exploitation of intracellular pH gradients in the cellular delivery of macromolecules. , 2002, Journal of pharmaceutical sciences.

[28]  A. Hall,et al.  Cation transport by a redox-active synthetic ion channel. , 2003, Organic & biomolecular chemistry.

[29]  U. Koert,et al.  Synthetic efficiency and functional selectivity: two goals for synthetic ion channels , 2002 .

[30]  M. Sansom,et al.  Protonation of lysine residues inverts cation/anion selectivity in a model channel. , 2000, Biophysical journal.

[31]  S. Matile,et al.  Voltage-dependent formation of anion channels by synthetic rigid-rod push-pull beta-barrels. , 2003, Chemistry.

[32]  A. R. Freeman,et al.  Synthetic peptides form ion channels in artificial lipid bilayer membranes. , 1977, Science.

[33]  C. T. Miller,et al.  The synthesis and screening of 1,4,5,8-naphthalenetetracarboxylic diimide-peptide conjugates with antibacterial activity. , 2001, Bioorganic & medicinal chemistry.

[34]  S. Matile,et al.  Binding of Organic Anions by Synthetic Supramolecular Metallopores with Internal Mg2+–Aspartate Complexes , 2002, Chembiochem : a European journal of chemical biology.

[35]  C. Toniolo,et al.  Zinc(II) as an allosteric regulator of liposomal membrane permeability induced by synthetic template-assembled tripodal polypeptides. , 2002, Chemistry.

[36]  Youxing Jiang,et al.  The principle of gating charge movement in a voltage-dependent K+ channel , 2003, Nature.

[37]  S. Matile,et al.  Outer surface modification of synthetic multifunctional pores. , 2004, Bioorganic & medicinal chemistry.

[38]  S. Oiki,et al.  Voltage-dependent gating of an asymmetric gramicidin channel. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[39]  S. Matile,et al.  Transmembrane B‐DNA , 2000, Chembiochem : a European journal of chemical biology.

[40]  Jean-Marie Lehn,et al.  Comprehensive Supramolecular Chemistry , 1996 .

[41]  E. Rojas,et al.  Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[42]  T M Fyles,et al.  Bilayer membranes and transporter models. , 1997, Current opinion in chemical biology.

[43]  Bradley D. Smith,et al.  Facilitated phosphatidylserine (PS) flip-flop and thrombin activation using a synthetic PS scramblase. , 2003, Journal of the American Chemical Society.

[44]  Molecular design and synthesis of artificial ion channels based on cyclic peptides containing unnatural amino acids. , 2001, The Journal of organic chemistry.

[45]  M. Mutter,et al.  Template-Assembled Synthetic Proteins Designed To Adopt a Globular, Four-Helix Bundle Conformation Form Ionic Channels in Lipid Bilayers , 1993 .

[46]  G. Tew,et al.  Cationic Facially Amphiphilic Poly(phenylene ethynylene)s Studied at the Air−Water Interface , 2003 .

[47]  M. Flonta,et al.  Interaction of the antioxidant flavonoid quercetin with planar lipid bilayers. , 2000, International journal of pharmaceutics.

[48]  K. Nagai,et al.  BE‐18591 as a new H+/Cl− symport ionophore that inhibits immunoproliferation and gastritis , 2002, FEBS letters.

[49]  S. Gellman,et al.  Mimicry of Host-Defense Peptides by Unnatural Oligomers: Antimicrobial β-Peptides , 2002 .

[50]  R. Bisby,et al.  Wavelength-programmed solute release from photosensitive liposomes. , 2000, Biochemical and biophysical research communications.

[51]  K. Müllen,et al.  Membrane Activity of Isophthalic Acid Derivatives: Ion Channel Formation by a Low Molecular Weight Compound , 2001 .

[52]  P. Eggers,et al.  Ion channels from linear and branched bola-amphiphiles. , 2003, The Journal of organic chemistry.

[53]  A. Mueller,et al.  Photoinitiated destabilization of sterically stabilized liposomes. , 2001, Biochimica et biophysica acta.

[54]  Rushana Azimova,et al.  The channel hypothesis of Huntington’s disease , 2001, Brain Research Bulletin.

[55]  S. Regen,et al.  Molecular Umbrella-Assisted Transport of a Hydrophilic Peptide Across a Phospholipid Membrane , 2000 .

[56]  R. Nolte.  Helical poly(isocyanides) , 1994 .

[57]  S. Regen,et al.  Molecular umbrella-assisted transport of glutathione across a phospholipid membrane. , 2001, Journal of the American Chemical Society.

[58]  Y. Shai,et al.  Interaction of the mammalian antibacterial peptide cecropin P1 with phospholipid vesicles. , 1995, Biochemistry.

[59]  D. Seebach,et al.  On the Antimicrobial and Hemolytic Activities of Amphiphilic β‐Peptides , 2001 .

[60]  Thomas M. Fyles,et al.  Biomimetic ion transport: a functional model of a unimolecular ion channel , 1989 .

[61]  M. Akeson,et al.  Biosensors for DNA sequence detection. , 2002, Current opinion in chemical biology.

[62]  George W. Gokel,et al.  Synthetic models of cation-conducting channels , 2001 .

[63]  C. Miller,et al.  Visible light‐induced destabilization of endocytosed liposomes , 2000, FEBS letters.

[64]  S. Matile,et al.  On the Importance of Intermediate Internal Charge Repulsion for the Synthesis of Multifunctional Pores , 2002 .

[65]  S. Schreiber,et al.  Transmembrane channels based on tartaric acid-gramicidin A hybrids. , 1989, Science.

[66]  G Andrew Woolley,et al.  Modeling ion channel regulation. , 2003, Current opinion in chemical biology.

[67]  M. Ghadiri,et al.  A Synthetic Pore-Mediated Transmembrane Transport of Glutamic Acid. , 2001, Angewandte Chemie.

[68]  W. DeGrado,et al.  beta-Peptides: from structure to function. , 2001, Chemical reviews.

[69]  S. Matile,et al.  On the electrostatics of cell-membrane recognition: from natural antibiotics to rigid push-pull rods. , 2000, Chemistry.

[70]  G. Gokel,et al.  The C-terminal ester of membrane anchored peptide ion channels affects anion transport. , 2003, Chemical communications.

[71]  Alan E Mark,et al.  Simulation of pore formation in lipid bilayers by mechanical stress and electric fields. , 2003, Journal of the American Chemical Society.

[72]  D. Seebach,et al.  Antibiotic and Hemolytic Activity of a β2/β3 Peptide Capable of Folding into a 12/10‐Helical Secondary Structure , 2003 .

[73]  H. Minakata,et al.  Poly-L-glutamine forms cation channels: relevance to the pathogenesis of the polyglutamine diseases. , 2000, Biophysical journal.

[74]  R. Nagaraj,et al.  Norbornene-constrained cyclic peptides with hairpin architecture: design, synthesis, conformation, and membrane ion transport. , 2000, The Journal of organic chemistry.

[75]  J. M. Sanderson,et al.  The design, synthesis and characterisation of channel-forming peptides. , 2002, Chemical communications.

[76]  Bradley D. Smith,et al.  Synthetic membrane transporters. , 2002, Current opinion in chemical biology.

[77]  Gopal Das,et al.  Fluorometric Detection of Enzyme Activity with Synthetic Supramolecular Pores , 2002, Science.

[78]  S. Matile.  En route to supramolecular functional plasticity: artificial β-barrels, the barrel-stave motif, and related approaches , 2001 .

[79]  Jeffery T. Davis,et al.  Toward Artificial Ion Channels: A Lipophilic G-Quadruplex , 2000 .

[80]  F. Cohen,et al.  Toward the synthesis of artificial proteins: the discovery of an amphiphilic helical peptoid assembly. , 2002, Chemistry & biology.

[81]  H. Arndt,et al.  Cyclohexylether δ-Amino Acids: New Leads for Selectivity Filters in Ion Channels. , 2001, Angewandte Chemie.

[82]  L. Yang,et al.  Barrel-stave model or toroidal model? A case study on melittin pores. , 2001, Biophysical journal.

[83]  Stefan Matile,et al.  Rigid‐Rod β‐Barrel Ion Channels with Internal “Cascade Blue” Cofactors − Catalysis of Amide, Carbonate, and Ester Hydrolysis , 2002 .

[84]  S. Matile,et al.  Synthetic multifunctional pores: deletion and inversion of anion/cation selectivity using pM and pH. , 2003, Organic & biomolecular chemistry.

[85]  G. Gokel,et al.  A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes. , 2002, Chemical communications.

[86]  G. Gokel,et al.  The central ‘relay’ unit in hydraphile channels as a model for the water-and-ion ‘capsule’ of channel proteins , 2000 .

[87]  A. Barron,et al.  Helical peptoid mimics of magainin-2 amide. , 2003, Journal of the American Chemical Society.

[88]  G. Gokel,et al.  Spacer chain length dependence in hydraphile channels , 2001 .

[89]  Annalisa Pastore,et al.  From Alzheimer to Huntington: why is a structural understanding so difficult? , 2003, The EMBO journal.

[90]  Y. Kobuke,et al.  An Artificial Ion Channel Formed by a Macrocyclic Resorcin[4]arene with Amphiphilic Cholic Acid Ether Groups. , 2001, Angewandte Chemie.

[91]  Charles R. Martin,et al.  Resistive-Pulse SensingFrom Microbes to Molecules , 2000 .

[92]  N. Fujii,et al.  An antimicrobial peptide, magainin 2, induced rapid flip-flop of phospholipids coupled with pore formation and peptide translocation. , 1996, Biochemistry.

[93]  Annelise E Barron,et al.  Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers. , 2002, Current opinion in chemical biology.

[94]  Y. Kobuke,et al.  Transmembrane ion channels constructed of cholic acid derivatives. , 2001, The Journal of organic chemistry.

[95]  D. Seebach,et al.  Differential effects of temperature on E. coli and synthetic polyhydroxybutyrate/polyphosphate channels. , 2002, Biochemistry.

[96]  Bradley D. Smith,et al.  Membrane disruption ability of facially amphiphilic helical peptides. , 2002, Chemical communications.

[97]  Bradley D. Smith,et al.  Facilitated phospholipid flip-flop using synthetic steroid-derived translocases. , 2002, Journal of the American Chemical Society.

[98]  S. Regen,et al.  Selective transport of ATP across a phospholipid bilayer by a molecular umbrella. , 2003, Journal of the American Chemical Society.

[99]  S. Matile,et al.  Giant Artificial Ion Channels Formed by Self-Assembled, Cationic Rigid-Rodβ-Barrels , 2000 .

[100]  A. Gliozzi,et al.  Valinomycin acts as a channel in ultrathin lipid membranes. , 1996, Biochimica et biophysica acta.

[101]  M. Adrian,et al.  β‐Fibrillogenesis from Rigid‐Rod β‐Barrels: Hierarchical Preorganization Beyond Microns , 2001 .

[102]  S. Matile,et al.  Transmembrane pores formed by synthetic p-octiphenyl β-barrels with internal carboxylate clusters: Regulation of ion transport by pH and Mg2+- complexed 8-aminonaphthalene-1,3,6-trisulfonate , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[103]  R. J. Doerksen,et al.  Nontoxic membrane-active antimicrobial arylamide oligomers. , 2004, Angewandte Chemie.

[104]  J. Fuhrhop,et al.  Monensin 26-pyromellitate forms lithium channels in monolayer lipid membranes , 1984 .

[105]  W. DeGrado,et al.  De Novo Design, Synthesis, and Characterization of Antimicrobial β-Peptides , 2001 .

[106]  M. Ghadiri,et al.  Modulating ion channel properties of transmembrane peptide nanotubes through heteromeric supramolecular assemblies. , 2002, Journal of the American Chemical Society.

[107]  H. Bayley,et al.  Stochastic sensing of nanomolar inositol 1,4,5-trisphosphate with an engineered pore. , 2002, Chemistry & biology.

[108]  N. Voyer.  The development of peptide nanostructures , 1997 .

[109]  G. Miller.  The Puzzling Portrait of a Pore , 2003, Science.

[110]  Oscar Murillo,et al.  Synthetic Organic Chemical Models for Transmembrane Channels , 1996 .

[111]  L. Jones,et al.  Artificial ion channels formed by a synthetic cyclic peptide. , 2001, The journal of peptide research : official journal of the American Peptide Society.

[112]  J. Killian,et al.  Gramicidin channel controversy — revisited , 1999, Nature Structural Biology.

[113]  Michael J. Aziz,et al.  Ion-beam sculpting at nanometre length scales , 2001, Nature.

[114]  Jeffery T. Davis,et al.  Ion channel formation from a calix[4]arene amide that binds HCl. , 2002, Journal of the American Chemical Society.

[115]  P. Bandyopadhyay,et al.  Ion conductors derived from biogenic amines, bile acids, and amino acids. , 2002, Bioconjugate chemistry.

[116]  Fred J. Sigworth,et al.  Structural biology: Life's transistors , 2003, Nature.

[117]  P. Savage,et al.  Antibacterial properties of cationic steroid antibiotics. , 2002, FEMS microbiology letters.

[118]  M. Auger,et al.  Conformational and orientation studies of artificial ion channels incorporated into lipid bilayers. , 2000, Biopolymers.

[119]  W. Seufert.  Induced Permeability Changes in Reconstituted Cell Membrane Structure , 1965, Nature.

[120]  Pérez,et al.  A synthetic hydroxy acid that shows tubular-shaped structure in solid-state and ionophoric activity in phospholipid bilayers , 2000, Organic letters.

[121]  G. Gokel,et al.  Anchor chain length alters the apparent mechanism of chloride channel function in SCMTR derivatives. , 2003, Chemical communications.

[122]  N. Matsumori,et al.  Amphotericin B-phospholipid covalent conjugates: dependence of membrane-permeabilizing activity on acyl-chain length. , 2003, Organic & biomolecular chemistry.

[123]  P. Beer,et al.  Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics. , 2001, Chemistry.

[124]  A. Mueller,et al.  Visible-Light-Stimulated Destabilization of PEG-Liposomes , 2000 .

[125]  S. Matile,et al.  Anion-mediated transfer of polyarginine across liquid and bilayer membranes. , 2003, Journal of the American Chemical Society.

[126]  N. Voyer,et al.  A Synthetic Transmembrane Channel Active in Lipid Bilayers , 1997 .

[127]  Julio D. Martín,et al.  A synthetic transmembrane polyether model active in lipid bilayers. , 2000, Organic letters.

[128]  H. Sentenac,et al.  Cluster organization and pore structure of ion channels formed by beticolin 3, a nonpeptidic fungal toxin. , 1999, Biophysical journal.

[129]  Mark D. Hollingsworth.  Crystal Engineering: from Structure to Function , 2002, Science.

[130]  S. Matile.  Bioorganic chemistry à la baguette: studies on molecular recognition in biological systems using rigid-rod molecules. , 2001, Chemical record.

[131]  Y. Kobuke,et al.  Artificial ion channels showing rectified current behavior. , 2001, Journal of the American Chemical Society.

[132]  Rickert,et al.  Synthesis and Functional Studies of a Membrane-Bound THF-Gramicidin Cation Channel This work was supported by the Deutschen Forschungsgemeinschaft, the Fonds der Chemischen Industrie, the Volkswagenstiftung, Schering AG, and the Pinguin Foundation. , 2000, Angewandte Chemie.

[133]  H. Arndt,et al.  Synthesis of Minigramicidin Ion Channels and Test of Their Hydrophobic Match with the Membrane , 2001, Chembiochem : a European journal of chemical biology.

[134]  S. Matile,et al.  α-Helix recognition by rigid-rod β-barrel ion channels with internal arginine-histidine dyads in polarized bilayer membranes , 2002 .

[135]  H. Fenniri,et al.  Helical rosette nanotubes with tunable chiroptical properties. , 2002, Journal of the American Chemical Society.

[136]  John T. Groves,et al.  Tetraphilin : a four-helix proton channel built on a tetraphenylporphyrin framework , 1992 .

[137]  Anna K. Schrey,et al.  Electrophysiological response of cultured trabecular meshwork cells to synthetic ion channels. , 2003, Chemistry & biology.

[138]  F. Szoka,et al.  Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG--diortho ester--lipid conjugate. , 2001, Bioconjugate chemistry.

[139]  G. Gokel,et al.  Replacing proline at the apex of heptapeptide-based chloride ion transporters alters their properties and their ionophoretic efficacy , 2003 .

[140]  C. D. Hall,et al.  Supramolecular assemblies in natural and artificial ion channels , 2000 .

[141]  I. Izzo,et al.  C2-symmetrical sterol–polyether conjugates as highly efficient synthetic ionophores , 2003 .

[142]  Y. Kobuke,et al.  Supramolecular ion channel containing trans-azobenzene for photocontrol of ionic fluxes , 2000 .

[143]  S. Gellman,et al.  Interactions of the antimicrobial β‐peptide β‐17 with phospholipid vesicles differ from membrane interactions of magainins , 2003 .

[144]  I. Tabushi,et al.  A,B,D,F-tetrasubstituted β-cyclodextrin as artificial channel compound , 1982 .

[145]  G. Gokel,et al.  Hydraphile channels: models for transmembrane, cation-conducting transporters. , 2001, Chemistry.

[146]  Y. Okamoto,et al.  Stereospecific anionic polymerization of α-(alkoxymethyl)acrylate derivatives affording novel vinyl polymers with macrocyclic side chains , 2002 .

[147]  P. Bandyopadhyay,et al.  Evidence for an umbrella mechanism of bilayer transport. , 2001, Journal of the American Chemical Society.

[148]  S. Matile,et al.  Recognition of polarized lipid bilayers by p-oligophenyl ion channels: from push-pull rods to push-pull barrels. , 2002, Journal of the American Chemical Society.

[149]  H. Bayley,et al.  Stochastic sensors inspired by biology , 2001, Nature.

[150]  S. Gellman,et al.  Structure-activity studies of 14-helical antimicrobial beta-peptides: probing the relationship between conformational stability and antimicrobial potency. , 2002, Journal of the American Chemical Society.

[151]  J. Karanicolas,et al.  Voltage-dependent behavior of a "ball-and-chain" gramicidin channel. , 1997, Biophysical journal.

[152]  John A. Robinson,et al.  Macrocyclic Hairpin Mimetics of the Cationic Antimicrobial Peptide Protegrin I: A New Family of Broad‐Spectrum Antibiotics , 2002, Chembiochem : a European journal of chemical biology.

[153]  S. Regen,et al.  Molecular umbrella-assisted transport of thiolated AMP and ATP across phospholipid bilayers. , 2002, Bioconjugate chemistry.

[154]  G. Gokel,et al.  A Synthetic Cation-Transporting Calix[4]arene Derivative Active in Phospholipid Bilayers. , 1998, Angewandte Chemie.

[155]  E. Neumann,et al.  Fatty Acid-Oligo(ethylene glycol) Ester Forms Ion Channels in Lipid Membranes This contribution was supported by the Deutsche Forschungsgemeinschaft (SFB 424: Molekulare Orientierung als Funktionskriterium in chemischen Systemen). , 2000, Angewandte Chemie.

[156]  Jianbing Zhang,et al.  Kinetic evidence for the existence and mechanism of formation of a barrel stave structure from pore-forming dendrimers. , 2003, Journal of the American Chemical Society.

[157]  M. Nantz,et al.  Self-Cleaving Ortho Ester Lipids: A New Class of pH-Vulnerable Amphiphiles , 2000 .

[158]  A. Klibanov,et al.  Mechanism of bactericidal and fungicidal activities of textiles covalently modified with alkylated polyethylenimine. , 2003, Biotechnology and bioengineering.

[159]  Y. Kirino,et al.  Blepharismins, produced by the protozoan, Blepharisma japonicum, form ion‐permeable channels in planar lipid bilayer membranes , 2001, FEBS letters.

[160]  S. Gellman,et al.  Toward beta-peptide tertiary structure: self-association of an amphiphilic 14-helix in aqueous solution. , 2001, Organic letters.

[161]  Jean Campbell,et al.  Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[162]  S. Gellman,et al.  Antibiotics: Non-haemolytic β-amino-acid oligomers , 2000, Nature.

[163]  C. Foces-Foces,et al.  Tubular hydrogen-bonded networks sustained by water molecules. , 2001, Journal of the American Chemical Society.

[164]  D. Branton,et al.  Characterization of nucleic acids by nanopore analysis. , 2002, Accounts of chemical research.

[165]  P. Schlieper,et al.  Triton X-100 as a channel-forming substance in artificial lipid bilayer membranes. , 1977, Archives of biochemistry and biophysics.

[166]  F. Szoka,et al.  Chemical approaches to triggerable lipid vesicles for drug and gene delivery. , 2003, Accounts of chemical research.

[167]  A. Vescovi,et al.  Synthesis and functional studies of THF-gramicidin hybrid ion channels. , 2003, Organic & biomolecular chemistry.

[168]  R. Nagaraj,et al.  Design, synthesis and membrane ion transport properties of cystine- and serine-based Cyclo-4-oxa-heptane-1,7-bisamides , 2002 .

[169]  T. Andreoli,et al.  On the anatomy of amphotericin B-cholesterol pores in lipid bilayer membranes. , 1973, Kidney international.

[170]  Stefan Matile,et al.  Synthetic catalytic pores. , 2003, Journal of the American Chemical Society.

[171]  S. Matile,et al.  Electrostatics of cell membrane recognition: structure and activity of neutral and cationic rigid push-pull rods in isoelectric, anionic, and polarized lipid bilayer membranes. , 2001, Journal of the American Chemical Society.

[172]  Bradley D. Smith,et al.  Molecular ferries: membrane carriers that promote phospholipid flip-flop and chloride transport. , 2003, Chemical communications.

[173]  M. Cadene,et al.  X-ray structure of a voltage-dependent K+ channel , 2003, Nature.

[174]  Stefan Matile,et al.  Complementary characteristics of homologous p-octiphenyl beta-barrels with ion channel and esterase activity. , 2003, Bioorganic & medicinal chemistry.

[175]  J. Lehn,et al.  An approach to channel-type molecular structures. Part 3. Incorporation studies of the bouquet-shaped BM and BCD in phosphatidylcholine vesicles , 1993 .

[176]  V. Paraschiv,et al.  Complexation of phenolic guests by endo- and exo-hydrogen-bonded receptors. , 2003, Organic & biomolecular chemistry.

[177]  C. Griesinger,et al.  Cation control in functional helical programming: structures of a D,L-peptide ion channel. , 2002, Angewandte Chemie.

[178]  Chih‐Wei Hu,et al.  Synthesis and membrane activity of a bis(metacyclophane)bolaamphiphile. , 2002, The Journal of organic chemistry.

[179]  F. Szoka,et al.  Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid. , 2003, Biophysical journal.

[180]  F. J. Sigworth,et al.  Gramicidin channel controversy — the structure in a lipid environment , 1999, Nature Structural Biology.

[181]  Gopal Das,et al.  Enzyme screening with synthetic multifunctional pores: Focus on biopolymers , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[182]  P. Läuger.  Mechanisms of Biological Ion Transport — Carriers, Channels, and Pumps in Artificial Lipid Membranes , 1985 .

[183]  P. Bandyopadhyay,et al.  Ion conductors derived from cholic acid and spermine: importance of facial hydrophilicity on NA(+) transport and membrane selectivity. , 2001, Journal of the American Chemical Society.

[184]  M. Zasloff.  Antimicrobial peptides of multicellular organisms , 2002, Nature.

[185]  D. M. Lynn,et al.  Biocidal activity of polystyrenes that are cationic by virtue of protonation. , 2004 .

[186]  W. Duax,et al.  Gramicidin channel controversy — reply , 1999, Nature Structural Biology.

[187]  U. Gräfe,et al.  Cation selective ion channels formed by macrodiolide antibiotic elaiophylin in lipid bilayer membranes. , 2001, Bioelectrochemistry.

[188]  H. Bayley,et al.  Kinetics of a three-step reaction observed at the single-molecule level. , 2003, Angewandte Chemie.

[189]  S. Matile,et al.  Toward p-octiphenyl β-barrel RNases , 2002 .

[190]  Y. Okamoto,et al.  Anionic polymerization of macrocyclic α-(alkoxymethyl)acrylates leading to novel vinyl polymer with crown ether type side chain , 2002 .

[191]  G. Gokel,et al.  SCMTR: a chloride-selective, membrane-anchored peptide channel that exhibits voltage gating. , 2002, Journal of the American Chemical Society.

[192]  R. J. Doerksen,et al.  De novo design of biomimetic antimicrobial polymers , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[193]  Jean Campbell,et al.  Bioinspired pH-responsive polymers for the intracellular delivery of biomolecular drugs. , 2003, Bioconjugate chemistry.

[194]  D. Deamer,et al.  Alpha-helical hydrophobic polypeptides form proton-selective channels in lipid bilayers. , 1994, Biophysical journal.

[195]  K. Harms,et al.  Oligo‐THF Peptides: Synthesis, Membrane Insertion, and Studies of Ion Channel Activity , 1996 .

[196]  J. Fuhrhop,et al.  Membranes and Molecular Assemblies: The Synkinetic Approach , 1998 .

[197]  K. Yamashita,et al.  Amphotericin B Mimics: A Sterol-Based Ionophore , 1994 .

[198]  S. Otto,et al.  Ion Conductors that Favor Passive Transport in Ergosterol-Rich over Cholesterol-Rich Phospholipid Membranes , 2000 .

[199]  Juan R. Granja,et al.  Antibacterial agents based on the cyclic d,l-α-peptide architecture , 2001, Nature.

[200]  A. Hall,et al.  Towards a redox-active artificial ion channel , 1999 .

[201]  A. Hoffman,et al.  pH-Sensitive hemolysis by random copolymers of alkyl acrylates and acrylic acid , 2001 .

[202]  Anna K. Schrey,et al.  Solution phase synthesis and purification of the minigramicidin ion channels and a succinyl-linked gramicidin , 2002 .

[203]  C G Morgan,et al.  Active Uptake of Drugs into Photosensitive Liposomes and Rapid Release on UV Photolysis¶ , 2000, Photochemistry and photobiology.

[204]  J. Slotte,et al.  Characterization of flavonoid--biomembrane interactions. , 2002, Archives of biochemistry and biophysics.

[205]  T. Fyles,et al.  Transmembrane ion conductance by an acyclic bolaamphiphile. , 2001, Organic letters.

[206]  Sergey M. Bezrukov,et al.  Designed to penetrate: Time-resolved interaction of single antibiotic molecules with bacterial pores , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[207]  Y. Kobuke,et al.  A Supramolecular Ion Channel Based on Amphiphilic Cholic Acid Derivatives. , 2000 .

[208]  T. Iwamoto,et al.  Distinct structural elements that direct solution aggregation and membrane assembly in the channel-forming peptide M2GlyR. , 2002, Biochemistry.

[209]  D. Cafiso,et al.  Membrane mimetic environments alter the conformation of the outer membrane protein BtuB. , 2003, Journal of the American Chemical Society.

[210]  M. Gross,et al.  Evidence for multiple alkali metal cation complexation in membrane-spanning ion transporters , 2000 .

[211]  G. Gokel,et al.  Enhancement of cation transport in synthetic hydraphile channels having covalently-linked headgroups , 2000 .

[212]  J. Winum,et al.  Rigid Push−Pull Oligo(p-Phenylene) Rods: Depolarization of Bilayer Membranes with Negative Membrane Potential , 1999 .

[213]  N. Kimizuka.  Self-assembly in mesoscopic dimension and artificial supramolecular membranes. , 2003, Current opinion in chemical biology.