AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.
暂无分享,去创建一个
M. Nussenzweig | T. Ried | Kevin M. McBride | A. Nussenzweig | Thomas R. Eisenreich | D. Robbiani | Isaac A. Klein | Anne Bothmer | J. Camps | S. Bunting | N. Feldhahn | S. Deroubaix | Gary C Stone
[1] T. Ried,et al. Chimeric IgH-TCRα/δ translocations in T lymphocytes mediated by RAG , 2009 .
[2] F. Alt,et al. Mechanisms promoting translocations in editing and switching peripheral B cells , 2009, Nature.
[3] Wei Gu,et al. Modes of p53 Regulation , 2009, Cell.
[4] T. Rabbitts,et al. Commonality but Diversity in Cancer Gene Fusions , 2009, Cell.
[5] Alexandre Orthwein,et al. Active nuclear import and cytoplasmic retention of activation-induced deaminase , 2009, Nature Structural &Molecular Biology.
[6] D. Green,et al. Cytoplasmic functions of the tumour suppressor p53 , 2009, Nature.
[7] F. Alt,et al. Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice , 2009, Proceedings of the National Academy of Sciences.
[8] M. Nussenzweig,et al. AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations , 2008, Cell.
[9] M. Lieber,et al. Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity , 2008, Cell.
[10] B. Chait,et al. Regulation of class switch recombination and somatic mutation by AID phosphorylation , 2008, The Journal of experimental medicine.
[11] B. Hoffman,et al. Apoptotic signaling by c-MYC , 2008, Oncogene.
[12] F. Alt,et al. AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development , 2008, The Journal of experimental medicine.
[13] M. Lieber,et al. Mechanistic aspects of lymphoid chromosomal translocations. , 2008, Journal of the National Cancer Institute. Monographs.
[14] J. Weill,et al. Proteasomal degradation restricts the nuclear lifespan of AID , 2008 .
[15] Thomas Tuschl,et al. MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. , 2008, Immunity.
[16] Michel C Nussenzweig,et al. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. , 2008, Immunity.
[17] Kevin M. McBride,et al. Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney. , 2008, Molecular immunology.
[18] C. E. Schrader,et al. Mechanism and regulation of class switch recombination. , 2008, Annual review of immunology.
[19] Sergio Roa,et al. The biochemistry of somatic hypermutation. , 2008, Annual review of immunology.
[20] D. Schatz,et al. Two levels of protection for the B cell genome during somatic hypermutation , 2008, Nature.
[21] G. Teng,et al. Immunoglobulin somatic hypermutation. , 2007, Annual review of genetics.
[22] T. Ried,et al. AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements , 2007, The Journal of experimental medicine.
[23] M. Nussenzweig,et al. A role for AID in chromosome translocations between c-myc and the IgH variable region , 2007, The Journal of experimental medicine.
[24] M. Nussenzweig,et al. Antigen receptor diversification and chromosome translocations , 2007, Nature Immunology.
[25] H. Inagaki. Mucosa‐associated lymphoid tissue lymphoma: Molecular pathogenesis and clinicopathological significance , 2007, Pathology international.
[26] M. Nussenzweig,et al. ATM Prevents the Persistence and Propagation of Chromosome Breaks in Lymphocytes , 2007, Cell.
[27] C. Sander,et al. A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing , 2007, Cell.
[28] M. Neuberger,et al. Molecular mechanisms of antibody somatic hypermutation. , 2007, Annual review of biochemistry.
[29] N. Carter,et al. Ultra-high resolution array painting facilitates breakpoint sequencing , 2006, Journal of Medical Genetics.
[30] M. Lieber,et al. Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations. , 2006, DNA repair.
[31] M. Nussenzweig,et al. Switching on chromosomal translocations. , 2006, Cancer research.
[32] Vasco M. Barreto,et al. Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[33] Michel C. Nussenzweig,et al. Role of genomic instability and p53 in AID-induced c-myc–Igh translocations , 2006, Nature.
[34] Yoshimasa Tanaka,et al. Negative regulation of activation-induced cytidine deaminase in B cells. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[35] D. Robbiani,et al. Maintained rules of development in a mouse B-cell tumor , 2005, Leukemia.
[36] K. Manova,et al. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models , 2005, Nature Cell Biology.
[37] Ralf Küppers,et al. Mechanisms of B-cell lymphoma pathogenesis , 2005, Nature Reviews Cancer.
[38] M. Nussenzweig,et al. Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[39] Ryan T. Phan,et al. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells , 2004, Nature.
[40] S. Lowe,et al. Intrinsic tumour suppression , 2004, Nature.
[41] M. Nussenzweig,et al. ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions , 2004, The Journal of experimental medicine.
[42] D. Schatz,et al. Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc , 2004, Nature Immunology.
[43] M. Nussenzweig,et al. AID Is Required for c-myc/IgH Chromosome Translocations In Vivo , 2004, Cell.
[44] Samuel H. Wilson,et al. Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. , 2004, The Journal of clinical investigation.
[45] M. Nussenzweig,et al. 53BP1 is required for class switch recombination , 2004, The Journal of cell biology.
[46] Vasco M. Barreto,et al. Somatic Hypermutation Is Limited by CRM1-dependent Nuclear Export of Activation-induced Deaminase , 2004, The Journal of experimental medicine.
[47] F. Alt,et al. 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination , 2004, Nature Immunology.
[48] D. Bartel,et al. MicroRNAs Modulate Hematopoietic Lineage Differentiation , 2004, Science.
[49] M. Greaves,et al. Origins of chromosome translocations in childhood leukaemia , 2003, Nature Reviews Cancer.
[50] F. Alt,et al. Histone H2AX A Dosage-Dependent Suppressor of Oncogenic Translocations and Tumors , 2003, Cell.
[51] M. Potter. Neoplastic development in plasma cells , 2003, Immunological reviews.
[52] N. Kakazu,et al. Constitutive Expression of AID Leads to Tumorigenesis , 2003, The Journal of experimental medicine.
[53] L. Staudt,et al. Decision making in the immune system: Lymphoid Malignancies: the dark side of B-cell differentiation , 2002, Nature Reviews Immunology.
[54] M. Neuberger,et al. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification , 2002, Nature.
[55] F. Alt,et al. The Mechanism and Regulation of Chromosomal V(D)J Recombination , 2002, Cell.
[56] D. Schatz. V(D)J recombination , 2002, Immunological reviews.
[57] Thomas Ried,et al. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching , 2001, Nature.
[58] Riccardo Dalla-Favera,et al. Mechanisms of chromosomal translocations in B cell lymphomas , 2001, Oncogene.
[59] K. Rajewsky,et al. Contribution of Receptor Editing to the Antibody Repertoire , 2001, Science.
[60] T. Honjo,et al. Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme , 2000, Cell.
[61] L. Pasqualucci,et al. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[62] U. Storb,et al. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. , 1998, Science.
[63] M. Qumsiyeh,et al. No Requirement for V(D)J Recombination in p53-Deficient Thymic Lymphoma , 1998, Molecular and Cellular Biology.
[64] R. Weinberg,et al. Tumor spectrum analysis in p53-mutant mice , 1994, Current Biology.
[65] J. Langhorne,et al. Role of gamma interferon during infection with Plasmodium chabaudi chabaudi , 1990, Infection and immunity.
[66] P. Nowell,et al. Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[67] L. Staudt,et al. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[68] S. Tonegawa. Somatic generation of antibody diversity , 1983, Nature.
[69] L. Pasqualucci,et al. AID is required for germinal center–derived lymphomagenesis , 2008, Nature Genetics.
[70] Vasco M. Barreto,et al. The role of activation-induced deaminase in antibody diversification and chromosome translocations. , 2007, Advances in immunology.
[71] M. Schlissel,et al. Leukemia and lymphoma: a cost of doing business for adaptive immunity. , 2006, Genes & development.
[72] F. Alt,et al. Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. , 2005, Advances in immunology.
[73] T. Honjo,et al. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. , 2002, Annual review of immunology.
[74] W. Peters,et al. The chemotherapy of rodent malaria. LVIII. Drug combinations to impede the selection of drug resistance, Part. 2: The new generation--artemisinin or artesunate with long-acting blood schizontocides. , 2000, Annals of tropical medicine and parasitology.