Aptamer-mediated blockade of IL4Rα triggers apoptosis of MDSCs and limits tumor progression.
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P. Serafini | F. Roth | A. C. De La Fuente | J. L. Vella | A. Zoso | L. Inverardi | P. Serafini | A. Zoso | L. Inverardi | Jennifer L. Vella | Adriana De La Fuente | Felix Roth | Alessia Zoso
[1] J. Califano,et al. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function , 2006, The Journal of experimental medicine.
[2] B. Fingleton,et al. Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. , 2004, Cancer cell.
[3] F. Finkelman,et al. Untangling the Complex Web of IL-4– and IL-13–Mediated Signaling Pathways , 2008, Science Signaling.
[4] M. Karin,et al. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4 , 2004, Nature.
[5] M. Taura,et al. TLR3 induction by anticancer drugs potentiates poly I:C‐induced tumor cell apoptosis , 2010, Cancer science.
[6] K. Node,et al. STAT6 Mediates Apoptosis of Human Coronary Arterial Endothelial Cells by Interleukin-13 , 2008, Hypertension Research.
[7] T. Fitzwater,et al. A SELEX primer. , 1996, Methods in enzymology.
[8] G. Barber,et al. PKR, apoptosis and cancer. , 1999, The international journal of biochemistry & cell biology.
[9] S. Ugel,et al. Therapeutic targeting of myeloid-derived suppressor cells. , 2009, Current opinion in pharmacology.
[10] R. Ronca,et al. Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. , 2000, Blood.
[11] M. Hansmann,et al. STAT6 and STAT1 are essential antagonistic regulators of cell survival in classical Hodgkin lymphoma cell line , 2009, Leukemia.
[12] D. Weissman,et al. mRNA Is an Endogenous Ligand for Toll-like Receptor 3* , 2004, Journal of Biological Chemistry.
[13] H. Giladi,et al. TLR3 signaling in a hepatoma cell line is skewed towards apoptosis , 2007, Journal of cellular biochemistry.
[14] S. Lebecque,et al. TLR3 Can Directly Trigger Apoptosis in Human Cancer Cells1 , 2006, The Journal of Immunology.
[15] S. Biswas,et al. Characterization of the nature of granulocytic myeloid‐derived suppressor cells in tumor‐bearing mice , 2012, Journal of leukocyte biology.
[16] H. Young,et al. Immortalized Myeloid Suppressor Cells Trigger Apoptosis in Antigen-Activated T Lymphocytes1 , 2000, The Journal of Immunology.
[17] A. Keefe,et al. SELEX with modified nucleotides. , 2008, Current opinion in chemical biology.
[18] J. Berzofsky,et al. Role of IL-13 in regulation of anti-tumor immunity and tumor growth , 2004, Cancer Immunology, Immunotherapy.
[19] G. Mayer. The chemical biology of aptamers. , 2009, Angewandte Chemie.
[20] S. Mocellin,et al. IL4Rα+ Myeloid-Derived Suppressor Cell Expansion in Cancer Patients1 , 2009, The Journal of Immunology.
[21] Maria R. Gumina,et al. Cutting Edge: IL-4-Mediated Protection of Primary B Lymphocytes from Apoptosis via Stat6-Dependent Regulation of Glycolytic Metabolism1 , 2007, The Journal of Immunology.
[22] P. Giangrande,et al. Therapeutic applications of DNA and RNA aptamers. , 2009, Oligonucleotides.
[23] Srinivas Nagaraj,et al. Myeloid-derived suppressor cells as regulators of the immune system , 2009, Nature Reviews Immunology.
[24] Sudhir Srivastava,et al. Posttranslational Protein Modifications , 2006, Molecular & Cellular Proteomics.
[25] Jay A. Berzofsky,et al. NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway , 2000, Nature Immunology.
[26] Takashi Tanaka,et al. The biology of Stat4 and Stat6 , 2000, Oncogene.
[27] C. Alam,et al. Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes , 2011, European journal of immunology.
[28] P. Bevilacqua,et al. Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure‐specific manner , 2008, RNA.
[29] Michelle Collazo,et al. Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice1 , 2008, The Journal of Immunology.
[30] L. Coussens,et al. MMP9 potentiates pulmonary metastasis formation. , 2002, Cancer cell.
[31] B. Ma,et al. ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. , 2005, The Journal of clinical investigation.
[32] R. Ronca,et al. Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. , 2000, Blood.
[33] D. Green,et al. Apoptosis and cancer. , 1994, Important advances in oncology.
[34] D. Friend,et al. Monoclonal antibodies block murine IL-4 receptor function. , 1990, Journal of immunology.
[35] Rong-cheng Luo,et al. Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells , 2011, Cell biology international.
[36] M. Colombo,et al. IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice1 , 2003, The Journal of Immunology.
[37] Paolo Serafini,et al. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. , 2006, The Journal of clinical investigation.
[38] D. Togninalli,et al. IL-4 and IL-13, But Not IL-10, Protect Human Synoviocytes from Apoptosis1 , 2001, The Journal of Immunology.
[39] S. Bicciato,et al. Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. , 2010, Immunity.
[40] B. Sullenger,et al. Gene therapy progress and prospects: RNA aptamers , 2007, Gene Therapy.
[41] J. Berzofsky,et al. Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte–mediated Tumor Immunosurveillance , 2003, The Journal of Experimental Medicine.
[42] I. Borrello,et al. Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. , 2008, Cancer research.
[43] S. Gordon,et al. Alternative activation of macrophages: mechanism and functions. , 2010, Immunity.
[44] G. Peters,et al. Phosphorylation of Specific Serine Residues in the PKR Activation Domain of PACT Is Essential for Its Ability to Mediate Apoptosis* , 2006, Journal of Biological Chemistry.
[45] W. Paul,et al. Interleukin 4 receptor: signaling mechanisms. , 1994, Immunology today.
[46] P. Sinha,et al. Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis. , 2005, Cancer research.
[47] A. Theocharis,et al. Chondroitin sulfate as a key molecule in the development of atherosclerosis and cancer progression. , 2006, Advances in pharmacology.
[48] I. Dusanter-Fourt,et al. Interleukin‐4 induces human hepatocyte apoptosis through a Fas‐independent pathway , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.