The known unknowns of nanomaterials: Describing and characterizing uncertainty within environmental, health and safety risks

Various stakeholders have acknowledged that uncertainty within determining the potential environmental, health and safety (EHS) risks of nanomaterials (NM) may inhibit nanotechnology from reaching its full potential. A thorough description of such uncertainties is an imperative first step towards closing knowledge gaps and prioritizing research strategies. Through a qualitative uncertainty analysis which systematically screened 31 reports and articles published by leading scientists and authorities on the potential risks of NM, we found that knowledge gaps pervade nearly all aspects of basic EHS knowledge, with a well recognized need for improved testing procedures and equipment, human and environmental effect and exposure assessments and full characterization of NM. We also estimate the current level of knowledge to be at an early state of development, and further empirical research will most likely reduce most knowledge gaps. According to this analysis, research should be prioritized towards the assessment and development of test procedures and equipment and full characterization of NM in order to most effectively reduce uncertainties in the short term.

[1]  Richard Russell,et al.  Environmental Health and Safety Research Needs for Engineered Nanoscale Materials , 2006 .

[2]  Pratim Biswas,et al.  Assessing the risks of manufactured nanomaterials. , 2006, Environmental science & technology.

[3]  C. Hirsch,et al.  C60 fullerene: a powerful antioxidant or a damaging agent? The importance of an in-depth material characterization prior to toxicity assays. , 2009, Environmental pollution.

[4]  W. Walker,et al.  Defining Uncertainty: A Conceptual Basis for Uncertainty Management in Model-Based Decision Support , 2003 .

[5]  Richard D Handy,et al.  Manufactured nanoparticles: their uptake and effects on fish—a mechanistic analysis , 2008, Ecotoxicology.

[6]  M. Kandlikar,et al.  Health risk assessment for nanoparticles: A case for using expert judgment , 2006 .

[7]  J R Ravetz,et al.  A guidance for assessing and communicating uncertainties. , 2005, Water science and technology : a journal of the International Association on Water Pollution Research.

[8]  Hari Singh Nalwa,et al.  Nanotechnology and health safety--toxicity and risk assessments of nanostructured materials on human health. , 2007, Journal of nanoscience and nanotechnology.

[9]  Nigel J Walker,et al.  Research strategies for safety evaluation of nanomaterials, part II: toxicological and safety evaluation of nanomaterials, current challenges and data needs. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[10]  E. I. Sawin.  Taxonomy of Educational Objectives: The Classification of Educational Goals. Handbook 1. Committee of College and University Examiners, Benjamin S. Bloom , 1957 .

[12]  J. M. Davis,et al.  How to assess the risks of nanotechnology: learning from past experience. , 2007, Journal of nanoscience and nanotechnology.

[13]  M. B. Beck,et al.  Uncertainty and precaution in environmental management. , 2005, Water science and technology : a journal of the International Association on Water Pollution Research.

[14]  Peter A. Vanrolleghem,et al.  Uncertainty in the environmental modelling process - A framework and guidance , 2007, Environ. Model. Softw..

[15]  Scott E McNeil,et al.  Nanotechnology safety concerns revisited. , 2008, Toxicological sciences : an official journal of the Society of Toxicology.

[16]  Steffen Foss Hansen,et al.  Categorization framework to aid exposure assessment of nanomaterials in consumer products , 2008, Ecotoxicology.

[17]  Arie Rip,et al.  TAKING EUROPEAN KNOWLEDGE SOCIETY SERIOUSLY Report of the Expert Group on Science and Governance to the Science, Economy and Society Directorate, Directorate-General for Research, European Commission , 2007 .

[18]  M. Morris.  Understanding Risk - Informing Decisions in a Democratic Society , 1997 .

[19]  Lang Tran,et al.  Safe handling of nanotechnology , 2006, Nature.

[20]  B. P. Jones,et al.  British Standards Institution , 1943, Nature.

[21]  Nanna B. Hartmann,et al.  Ecotoxicity of engineered nanoparticles to aquatic invertebrates: a brief review and recommendations for future toxicity testing , 2008, Ecotoxicology.

[22]  G. Oberdörster,et al.  Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles , 2005, Environmental health perspectives.

[23]  D. G. Rickerby,et al.  Nanotechnology and the environment: A European perspective , 2007 .

[24]  Jerome R. Ravetz,et al.  Exploring the quality of evidence for complex and contested policy decisions , 2008 .

[25]  Y. Dori,et al.  Question-posing capability as an alternative evaluation method: Analysis of an environmental case study , 1999 .

[26]  S. Olsen,et al.  Limits and prospects of the "incremental approach" and the European legislation on the management of risks related to nanomaterials. , 2007, Regulatory toxicology and pharmacology : RTP.

[27]  Richard Handy,et al.  Formulating the problems for environmental risk assessment of nanomaterials. , 2007, Environmental science & technology.

[28]  Richard D. Handy,et al.  The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needs , 2008, Ecotoxicology.

[29]  Andrew D. Maynard,et al.  Nanotechnology: assessing the risks , 2006 .

[30]  B. Nowack,et al.  Occurrence, behavior and effects of nanoparticles in the environment. , 2007, Environmental pollution.

[31]  Benjamin S. Bloom,et al.  Taxonomy of Educational Objectives: The Classification of Educational Goals. , 1957 .

[32]  Kent E. Pinkerton,et al.  Meeting Report: Hazard Assessment for Nanoparticles—Report from an Interdisciplinary Workshop , 2007, Environmental health perspectives.

[33]  P. Wick,et al.  Reviewing the Environmental and Human Health Knowledge Base of Carbon Nanotubes , 2007, Environmental health perspectives.