From Heaven to Heart: Nitroxyl (HNO) in the Cardiovascular System and Beyond

[1]  A. Mebazaa,et al.  Agents with vasodilator properties in acute heart failure. , 2017, European heart journal.

[2]  Edward T Chouchani,et al.  A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury. , 2016, Cell metabolism.

[3]  B. Greenberg,et al.  Contemporary Treatment of Acute Heart Failure. , 2016, Progress in cardiovascular diseases.

[4]  Harald H. H. W. Schmidt,et al.  Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications , 2015, Antioxidants & redox signaling.

[5]  M. Martí,et al.  Discussing endogenous NO(•)/HNO interconversion aided by phenolic drugs and vitamins. , 2015, Inorganic chemistry.

[6]  M. Singer,et al.  Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl , 2015, Proceedings of the National Academy of Sciences.

[7]  A. Mebazaa,et al.  Agents with vasodilator properties in acute heart failure: how to design successful trials , 2015, European journal of heart failure.

[8]  I. Ivanović‐Burmazović,et al.  Does perthionitrite (SSNO(-)) account for sustained bioactivity of NO? A (bio)chemical characterization. , 2015, Inorganic chemistry.

[9]  R. Ritchie,et al.  Chronic Administration of the Nitroxyl Donor 1-Nitrosocyclo Hexyl Acetate Limits Left Ventricular Diastolic Dysfunction in a Mouse Model of Diabetes Mellitus In Vivo , 2015, Circulation. Heart failure.

[10]  M. Martí,et al.  Nitric oxide is reduced to HNO by proton-coupled nucleophilic attack by ascorbate, tyrosine, and other alcohols. A new route to HNO in biological media? , 2015, Journal of the American Chemical Society.

[11]  S. Foo,et al.  A PHASE 1 STUDY OF THE SAFETY AND PHARMACOKINETICS OF THE INTRAVENOUS NITROXYL PRODRUG, CXL-1427 , 2015 .

[12]  N. Gamper,et al.  Redox and nitric oxide-mediated regulation of sensory neuron ion channel function. , 2015, Antioxidants & redox signaling.

[13]  D. Kass,et al.  Soluble Guanylate Cyclase Is Required for Systemic Vasodilation But Not Positive Inotropy Induced by Nitroxyl in the Mouse , 2015, Hypertension.

[14]  B. Greenberg,et al.  Safety and tolerability of omecamtiv mecarbil during exercise in patients with ischemic cardiomyopathy and angina. , 2015, JACC. Heart failure.

[15]  B. Kalyanaraman,et al.  Nitroxyl (HNO) Reacts with Molecular Oxygen and Forms Peroxynitrite at Physiological pH , 2014, The Journal of Biological Chemistry.

[16]  G. Derumeaux,et al.  Heme oxygenase-1: an emerging therapeutic target to curb cardiac pathology , 2014, Basic Research in Cardiology.

[17]  S. Brain,et al.  Calcitonin gene-related peptide: physiology and pathophysiology. , 2014, Physiological reviews.

[18]  J. Toscano,et al.  Comparison of HNO reactivity with tryptophan and cysteine in small peptides. , 2014, Bioorganic & medicinal chemistry letters.

[19]  J. Lennerz,et al.  H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway , 2014, Nature Communications.

[20]  J. Toscano,et al.  Reactivity of C-terminal cysteines with HNO. , 2014, Biochemistry.

[21]  J. Horowitz,et al.  The nitric oxide redox sibling nitroxyl partially circumvents impairment of platelet nitric oxide responsiveness. , 2013, Nitric oxide : biology and chemistry.

[22]  Dong I. Lee,et al.  HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization. , 2013, Antioxidants & redox signaling.

[23]  D. Kass,et al.  Nitroxyl (HNO): A Novel Approach for the Acute Treatment of Heart Failure , 2013, Circulation. Heart failure.

[24]  D. Wink,et al.  Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives. , 2013, Journal of medicinal chemistry.

[25]  Jason W. Labonte,et al.  NMR detection and study of hydrolysis of HNO-derived sulfinamides. , 2013, Biochemistry.

[26]  P. Pagliaro,et al.  Nitroglycerine and sodium trioxodinitrate: from the discovery to the preconditioning effect. , 2013, Journal of cardiovascular medicine.

[27]  W. Koch,et al.  Adrenergic Nervous System in Heart Failure: Pathophysiology and Therapy , 2013, Circulation research.

[28]  J. Horowitz,et al.  HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO. , 2013, American journal of physiology. Heart and circulatory physiology.

[29]  F. Cunha,et al.  The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats , 2013, Neuropharmacology.

[30]  C. Sobey,et al.  Nitroxyl (HNO) suppresses vascular Nox2 oxidase activity. , 2013, Free radical biology & medicine.

[31]  B. Massie,et al.  Effect of levosimendan on the short-term clinical course of patients with acutely decompensated heart failure. , 2013, JACC. Heart failure.

[32]  P. Buehler,et al.  Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. , 2013, Blood.

[33]  I. Ivanović‐Burmazović,et al.  Beyond H2S and NO interplay: hydrogen sulfide and nitroprusside react directly to give nitroxyl (HNO). A new pharmacological source of HNO. , 2013, Journal of medicinal chemistry.

[34]  C. Gondi,et al.  Cathepsin B as a cancer target , 2013, Expert opinion on therapeutic targets.

[35]  C. Gerloff,et al.  Pharmacological Characterization of 1-Nitrosocyclohexyl Acetate, a Long-Acting Nitroxyl Donor That Shows Vasorelaxant and Antiaggregatory Effects , 2013, The Journal of Pharmacology and Experimental Therapeutics.

[36]  Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin. , 2012, Free radical biology & medicine.

[37]  K. Anstrom,et al.  Ultrafiltration in decompensated heart failure with cardiorenal syndrome. , 2012, The New England journal of medicine.

[38]  D. Wink,et al.  Nitroxyl-Mediated Disulfide Bond Formation Between Cardiac Myofilament Cysteines Enhances Contractile Function , 2012, Circulation research.

[39]  F. Zouein,et al.  Acyloxy Nitroso Compounds Inhibit LIF Signaling in Endothelial Cells and Cardiac Myocytes: Evidence That STAT3 Signaling Is Redox-Sensitive , 2012, PloS one.

[40]  R. Hajjar,et al.  Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome , 2012, Circulation research.

[41]  J. Toscano,et al.  Reactivity of nitroxyl-derived sulfinamides. , 2012, Biochemistry.

[42]  R. Ritchie,et al.  Nitroxyl (HNO) Stimulates Soluble Guanylyl Cyclase to Suppress Cardiomyocyte Hypertrophy and Superoxide Generation , 2012, PloS one.

[43]  U. Förstermann,et al.  Nitric oxide synthases: regulation and function. , 2012, European heart journal.

[44]  G. Booz,et al.  Identification of a redox-sensitive switch within the JAK2 catalytic domain. , 2012, Free radical biology & medicine.

[45]  S. Lai,et al.  Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved. , 2012, The Journal of clinical investigation.

[46]  C. Sobey,et al.  Vasorelaxant and antiaggregatory actions of the nitroxyl donor isopropylamine NONOate are maintained in hypercholesterolemia. , 2011, American journal of physiology. Heart and circulatory physiology.

[47]  P. Ponikowski,et al.  Early drop in systolic blood pressure and worsening renal function in acute heart failure: renal results of Pre‐RELAX‐AHF , 2011, European journal of heart failure.

[48]  A. Wojtovich,et al.  Redox regulation of the mitochondrial K(ATP) channel in cardioprotection. , 2011, Biochimica et biophysica acta.

[49]  D. Wink,et al.  The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. , 2011, Antioxidants & redox signaling.

[50]  Garret A. FitzGerald,et al.  Prostaglandins and Inflammation , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[51]  R. Widdop,et al.  Chronic administration of the HNO donor Angeli's salt does not lead to tolerance, cross-tolerance, or endothelial dysfunction: comparison with GTN and DEA/NO. , 2011, Antioxidants & redox signaling.

[52]  C. Gerloff,et al.  Nitroxyl in the central nervous system. , 2011, Antioxidants & redox signaling.

[53]  K. Andrews,et al.  Nitroxyl (HNO) as a vasoprotective signaling molecule. , 2011, Antioxidants & redox signaling.

[54]  D. Cox,et al.  Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure , 2011, Science.

[55]  N. Nagahara.  Intermolecular disulfide bond to modulate protein function as a redox-sensing switch , 2011, Amino Acids.

[56]  J. Bian,et al.  Hydrogen sulfide interacts with nitric oxide in the heart: possible involvement of nitroxyl. , 2010, Cardiovascular research.

[57]  G. Dorn,et al.  Adrenergic signaling polymorphisms and their impact on cardiovascular disease. , 2010, Physiological reviews.

[58]  Nick D. Tsihlis,et al.  Isopropylamine NONOate (IPA/NO) moderates neointimal hyperplasia following vascular injury. , 2010, Journal of vascular surgery.

[59]  J. Goldhaber,et al.  Role of inotropic agents in the treatment of heart failure. , 2010, Circulation.

[60]  S. Moncada,et al.  Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia. , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[61]  D. Kass,et al.  Nitroxyl enhances myocyte Ca2+ transients by exclusively targeting SR Ca2+-cycling. , 2010, Frontiers in bioscience.

[62]  M. A. Wouters,et al.  Disulfides as redox switches: from molecular mechanisms to functional significance. , 2010, Antioxidants & redox signaling.

[63]  C. Gerloff,et al.  Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity , 2009, Journal of neurochemistry.

[64]  K. Andrews,et al.  A role for nitroxyl (HNO) as an endothelium‐derived relaxing and hyperpolarizing factor in resistance arteries , 2009, British journal of pharmacology.

[65]  D. Kass,et al.  Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics. , 2009, Pharmacology & therapeutics.

[66]  Jason C. Rogalski,et al.  Identification of Nitroxyl-induced Modifications in Human Platelet Proteins Using a Novel Mass Spectrometric Detection Method*S , 2009, Molecular & Cellular Proteomics.

[67]  S. Lancel,et al.  Nitroxyl Activates SERCA in Cardiac Myocytes via Glutathiolation of Cysteine 674 , 2009, Circulation research.

[68]  Christopher M. Pavlos,et al.  Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl. , 2008, Biochemistry.

[69]  M. Hukkanen,et al.  Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide. , 2008, Free radical biology & medicine.

[70]  G. C. Yeh,et al.  Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine. , 2008, Free radical biology & medicine.

[71]  Ming Lu,et al.  Nitroxyl inhibits breast tumor growth and angiogenesis , 2007, International journal of cancer.

[72]  N. Kaludercic,et al.  Examining nitroxyl in biological systems. , 2008, Methods in enzymology.

[73]  S. Moncada,et al.  Nitric oxide and mitochondrial signaling: from physiology to pathophysiology. , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[74]  D. Wink,et al.  The inhibition of glyceraldehyde-3-phosphate dehydrogenase by nitroxyl (HNO). , 2007, Archives of biochemistry and biophysics.

[75]  D. Kass,et al.  Nitroxyl increases force development in rat cardiac muscle , 2007, The Journal of physiology.

[76]  G. Dorn.  The Fuzzy Logic of Physiological Cardiac Hypertrophy , 2007, Hypertension.

[77]  R. Widdop,et al.  Nitroxyl Anion Donor, Angeli’s Salt, Does Not Develop Tolerance in Rat Isolated Aortae , 2007, Hypertension.

[78]  J. Fukuto,et al.  Antioxidant actions of nitroxyl (HNO). , 2007, Free radical biology & medicine.

[79]  B. Kemp-Harper,et al.  The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature. , 2007, Cardiovascular research.

[80]  M. Zaccolo,et al.  Nitroxyl Improves Cellular Heart Function by Directly Enhancing Cardiac Sarcoplasmic Reticulum Ca2+ Cycling , 2007, Circulation Research.

[81]  D. Kass,et al.  Peroxynitrite and myocardial contractility: in vivo versus in vitro effects. , 2006, Free radical biology & medicine.

[82]  J. Stasch,et al.  Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. , 2006, The Journal of clinical investigation.

[83]  D. Wink,et al.  Discriminating formation of HNO from other reactive nitrogen oxide species. , 2006, Free radical biology & medicine.

[84]  N. Bryan,et al.  N-Nitroso products from the reaction of indoles with Angeli's salt. , 2006, Chemical research in toxicology.

[85]  D. Kass,et al.  Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo. , 2005, Journal of medicinal chemistry.

[86]  T. Billiar,et al.  Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols. , 2005, Journal of the American Chemical Society.

[87]  J. Fukuto,et al.  Inhibition of yeast glycolysis by nitroxyl (HNO): mechanism of HNO toxicity and implications to HNO biology. , 2005, Archives of biochemistry and biophysics.

[88]  Richard J. Miller,et al.  Chemokines: Integrators of Pain and Inflammation , 2005, Nature Reviews Drug Discovery.

[89]  D. Kass,et al.  Calcitonin Gene-Related Peptide In Vivo Positive Inotropy Is Attributable to Regional Sympatho-Stimulation and Is Blunted in Congestive Heart Failure , 2005, Circulation research.

[90]  G. Salama,et al.  Nitroxyl triggers Ca2+ release from skeletal and cardiac sarcoplasmic reticulum by oxidizing ryanodine receptors. , 2005, Cell calcium.

[91]  Toshinori Suzuki,et al.  Nitration and nitrosation of N-acetyl-L-tryptophan and tryptophan residues in proteins by various reactive nitrogen species. , 2004, Free radical biology & medicine.

[92]  G. Meissner.  Molecular regulation of cardiac ryanodine receptor ion channel. , 2004, Cell calcium.

[93]  A. Ramachandran,et al.  Mechanisms of the interaction of nitroxyl with mitochondria. , 2004, The Biochemical journal.

[94]  H. Ohshima,et al.  Xanthine oxidase converts nitric oxide to nitroxyl that inactivates the enzyme. , 2004, Biochemical and biophysical research communications.

[95]  A. Franco‐Cereceda,et al.  Calcitonin gene-related peptide (CGRP) and capsaicin-induced stimulation of heart contractile rate and force , 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

[96]  D. Kass,et al.  Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm. , 2003, American journal of physiology. Heart and circulatory physiology.

[97]  D. Kass,et al.  A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[98]  D. Kass,et al.  Positive inotropic and lusitropic effects of HNO/NO− in failing hearts: Independence from β-adrenergic signaling , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[99]  D. Kass,et al.  Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning. , 2003, Free radical biology & medicine.

[100]  P. Naughton,et al.  Induction of Heme Oxygenase 1 by Nitrosative Stress , 2002, The Journal of Biological Chemistry.

[101]  K. Houk,et al.  The reduction potential of nitric oxide (NO) and its importance to NO biochemistry , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[102]  V. Shafirovich,et al.  Nitroxyl and its anion in aqueous solutions: Spin states, protic equilibria, and reactivities toward oxygen and nitric oxide , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[103]  I. Fridovich,et al.  Copper,Zinc Superoxide Dismutase as a Univalent NO−Oxidoreductase and as a Dichlorofluorescin Peroxidase* , 2001, The Journal of Biological Chemistry.

[104]  D. Kass,et al.  Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[105]  S. Viatchenko‐Karpinski,et al.  Modulation of the Ca2+‐induced Ca2+ release cascade by β‐adrenergic stimulation in rat ventricular myocytes , 2001 .

[106]  D. Kass,et al.  Oxygen radical-mediated reduction in basal and agonist-evoked NO release in isolated rat heart. , 2001, Journal of molecular and cellular cardiology.

[107]  A. Schechter,et al.  Biological action of nitric oxide donor compounds on platelets from patients with sickle cell disease , 2001, British journal of haematology.

[108]  Qian Wang,et al.  Arginine Conversion to Nitroxide by Tetrahydrobiopterin-free Neuronal Nitric-oxide Synthase , 2000, The Journal of Biological Chemistry.

[109]  L. Edvinsson,et al.  Positive inotropy mediated via CGRP receptors in isolated human myocardial trabeculae. , 2000, European journal of pharmacology.

[110]  N. Geacintov,et al.  The decomposition of peroxynitrite to nitroxyl anion (NO-) and singlet oxygen in aqueous solution. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[111]  F. Gao,et al.  Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[112]  V. Niketić,et al.  Exposure of Mn and FeSODs, but not Cu/ZnSOD, to NO leads to nitrosonium and nitroxyl ions generation which cause enzyme modification and inactivation: an in vitro study. , 1999, Free Radical Biology & Medicine.

[113]  H. Nagasawa,et al.  Mechanisms of inhibition of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide. , 1998, Biochemical pharmacology.

[114]  C. Cooper,et al.  Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite. , 1998, The Biochemical journal.

[115]  H. Nagasawa,et al.  Reaction between S-nitrosothiols and thiols: generation of nitroxyl (HNO) and subsequent chemistry. , 1998, Biochemistry.

[116]  James B. Mitchell,et al.  The cytotoxicity of nitroxyl: possible implications for the pathophysiological role of NO. , 1998, Archives of biochemistry and biophysics.

[117]  V. Der,et al.  Intracellular but not extracellular conversion of nitroxyl anion into nitric oxide leads to stimulation of human neutrophil migration. , 1998, The Biochemical journal.

[118]  T. Nolan,et al.  Nitroglycerin‐inhibited whole blood aggregation is partially mediated by calcitonin gene‐related peptide–a neurogenic mechanism , 1997, British journal of pharmacology.

[119]  J. Hare,et al.  Role of nitric oxide in the regulation of myocardial function. , 1995, Progress in cardiovascular diseases.

[120]  J. Stamler,et al.  NO+, NO, and NO- donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation. , 1995, Archives of biochemistry and biophysics.

[121]  M. Feelisch,et al.  Bioassay discrimination between nitric oxide (NO.) and nitroxyl (NO-) using L-cysteine. , 1994, Biochemical and biophysical research communications.

[122]  J. Tiedje,et al.  Denitrification: production and consumption of nitric oxide , 1994, Applied and environmental microbiology.

[123]  H. Nagasawa,et al.  Involvement of nitroxyl (HNO) in the cyanamide-induced vasorelaxation of rabbit aorta. , 1994, Biochemical pharmacology.

[124]  J. Fukuto,et al.  The pharmacological activity of nitroxyl: a potent vasodilator with activity similar to nitric oxide and/or endothelium-derived relaxing factor. , 1992, The Journal of pharmacology and experimental therapeutics.

[125]  H. Sies,et al.  Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[126]  H. Nagasawa,et al.  Evidence for nitroxyl in the catalase-mediated bioactivation of the alcohol deterrent agent cyanamide. , 1990, Journal of medicinal chemistry.

[127]  A. Bast,et al.  Reduction of β-adrenoceptor function by oxidative stress in the heart , 1990 .

[128]  R. Broene,et al.  Oxidation and reduction of hemoproteins by trioxodinitrate(II). The role of nitrosyl hydride and nitrite , 1988 .

[129]  J. M. Hollis,et al.  Radio detection of nitroxyl (HNO): the first interstellar NO bond. , 1977 .