Agonist in Rats-Opioid Receptor κ Prolonged Opportunity for Ischemic Neuroprotection with Selective

Tsung-Ying Chen, Toru Goyagi, Thomas J.K. Toung, Jeffrey R. Kirsch, Patricia D. Hurn, Agonist in Rats -Opioid Receptor κ Prolonged Opportunity for Ischemic Neuroprotection with Selective Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.0000125011.93188.c6 2004;35:1180-1185; originally published online March 18, 2004; Stroke. http://stroke.ahajournals.org/content/35/5/1180 World Wide Web at: The online version of this article, along with updated information and services, is located on the

[1]  J. Weinberger,et al.  Pentobarbital inhibits extracellular release of dopamine in the ischemic striatum , 1990, Journal of Neural Transmission / General Section JNT.

[2]  R. Koehler,et al.  Kappa-Opioid Receptor Selectivity for Ischemic Neuroprotection with BRL 52537 in Rats , 2003, Anesthesia and analgesia.

[3]  R. Koehler,et al.  Neuroprotective &kgr;-Opioid Receptor Agonist BRL 52537 Attenuates Ischemia-Evoked Nitric Oxide Production In Vivo in Rats , 2003, Stroke.

[4]  H. Fields,et al.  Kappa opioid receptor activation in the nucleus accumbens inhibits glutamate and GABA release through different mechanisms. , 2003, Journal of neurophysiology.

[5]  R. Koehler,et al.  Potent sigma 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats. , 2003, Anesthesia and analgesia.

[6]  V. Chefer,et al.  Modulation of the Behavioral and Neurochemical Effects of Psychostimulants by κ‐Opioid Receptor Systems , 2001, Annals of the New York Academy of Sciences.

[7]  L. Terenius,et al.  Modulation of neurotransmitter release in the basal ganglia of the rat brain by dynorphin peptides. , 1999, The Journal of pharmacology and experimental therapeutics.

[8]  E. Mackenzie,et al.  Differential time-course decreases in nonselective, mu-, delta-, and kappa-opioid receptors after focal cerebral ischemia in mice. , 1999, Stroke.

[9]  I. Acworth,et al.  The Measurement of Monoamine Neurotransmitters in Microdialysis Perfusates Using HPLC-ECD. , 1999, Methods in molecular medicine.

[10]  A. Schoffelmeer,et al.  κ1‐ and κ2‐opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum , 1997 .

[11]  D. Reich,et al.  Nitric Oxide Modulates Dopamine Release During Global Temporary Cerebral Ischemia , 1995, Anesthesia and analgesia.

[12]  J. Clemens,et al.  Ischemia increases tissue and decreases extracellular levels of acid dopamine metabolites in the rat striatum: further evidence for active transport of metabolites. , 1995, Life sciences.

[13]  F. Tortella,et al.  Evaluation of neuroprotection and behavioral recovery by the kappa-opioid, PD117302 following transient forebrain ischemia , 1994, Brain Research Bulletin.

[14]  J. Browning,et al.  Evaluation of Delayed Treatment of Focal Cerebral Ischemia With Three Selective K‐Opioid Agonists in Cats , 1994, Stroke.

[15]  D. Graham,et al.  Effect of the kappa-1 opioid agonist CI-977 on ischemic brain damage and cerebral blood flow after middle cerebral artery occlusion in the rat , 1993, Brain Research.

[16]  D. Reich,et al.  Effect of Isoflurane and Halothane on In Vivo Ischemia‐induced Dopamine Release in the Corpus Striatum of the Rat A Study Using Cerebral Microdialysis , 1993, Anesthesiology.

[17]  T. Kameyama,et al.  U-50,488H, a κ-opioid receptor agonist, markedly prevents memory dysfunctions induced by transient cerebral ischemia in mice , 1993, Brain Research.

[18]  G. Dondio,et al.  Substituted 1-(Aminomethyl)-2-(arylacetyl)-1,2,3,4- tetrahydroisoquinolines: A Novel Class of Very Potent Antinociceptive Agents with Varying Degrees of Selectivity for and μ Opioid Receptors. , 1992 .

[19]  G. Dondio,et al.  Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinolines: a novel class of very potent antinociceptive agents with varying degrees of selectivity for kappa and mu opioid receptors. , 1992, Journal of medicinal chemistry.

[20]  C. Chavkin,et al.  Kappa-opioids decrease excitatory transmission in the dentate gyrus of the guinea pig hippocampus , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[21]  D. Scopes,et al.  Neuroprotective actions of GR89696, a highly potent and selective kappa-opioid receptor agonist. , 1991, British journal of pharmacology.

[22]  A. Giordani,et al.  (2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics. , 1991, Journal of medicinal chemistry.

[23]  R. Busto,et al.  Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia , 1988, Neuroscience Letters.

[24]  R. Busto,et al.  Substantia nigra lesion protects against ischemic damage in the striatum , 1987, Neuroscience Letters.

[25]  J. Weinberger,et al.  Nerve terminal damage in cerebral ischemia: protective effect of alpha-methyl-para-tyrosine. , 1985, Stroke.

[26]  J. Weinberger,et al.  Nerve terminal damage in cerebral ischemia: greater susceptibility of catecholamine nerve terminals relative to serotonin nerve terminals. , 1983, Stroke.