AMINO ACID METABOLISM IN EXERCISE *

The fuel requirements of exercising muscle are largely met by the oxidation of glucose and free fatty acids. Amino acids are less important with respect to overall fuel economy. On the other hand, amino acids represent the carbon skeletons for de novo glucose synthesis. In addition, the utilization of amino acids as glucose precursors or as an oxidizable substrate represents the dissolution of body protein stores. Thus, with respect to overall glucose hemeostasis, the maintenance of body protein reserves, and the transfer of nitrogen between muscle and liver, amino acids occupy a central role.' This review will examine the effects of exercise on the metabolism of amino acids in muscle and liver as gleaned from studies in human subjects employing arterial and venous catheter techniques to study substrate exchange.

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