Selective efficacy of zoledronic acid on metastasis in a patient‐derived orthotopic xenograph (PDOX) nude‐mouse model of human pancreatic cancer

Patient‐derived orthotopic xenograft (PDOX) nude‐mouse models replicate the behavior of clinical cancer, including metastasis. The objective of the study was to determine the efficacy of zoledronic acid (ZA) on metastasis of a patient‐derived orthotopic xenograft (PDOX) nude‐mouse model of pancreatic cancer.

[1]  F. Guadagni,et al.  A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[2]  I. Fidler,et al.  Murine models to evaluate novel and conventional therapeutic strategies for cancer. , 2007, The American journal of pathology.

[3]  R. Hoffman,et al.  Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens. , 1993, Anticancer research.

[4]  I. Fidler,et al.  Orthotopic implantation is essential for the selection, growth and metastasis of human real cell cancer in nude mice , 1990, Cancer and Metastasis Reviews.

[5]  T. Pukrop,et al.  Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion , 2013, Oncotarget.

[6]  Yukihiko Hiroshima,et al.  Hand-held high-resolution fluorescence imaging system for fluorescence-guided surgery of patient and cell-line pancreatic tumors growing orthotopically in nude mice. , 2014, The Journal of surgical research.

[7]  I. Endo,et al.  Efficacy of Salmonella typhimurium A1‐R Versus Chemotherapy on a Pancreatic Cancer Patient‐Derived Orthotopic Xenograft (PDOX) , 2014, Journal of cellular biochemistry.

[8]  C. Boland,et al.  Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro , 2003, British Journal of Cancer.

[9]  K. Ohuchida,et al.  Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer , 2012, Cancer science.

[10]  I. Endo,et al.  The Tumor-Educated-Macrophage Increase of Malignancy of Human Pancreatic Cancer Is Prevented by Zoledronic Acid , 2014, PloS one.

[11]  R. Hwang,et al.  Molecular Profiling of Direct Xenograft Tumors Established from Human Pancreatic Adenocarcinoma After Neoadjuvant Therapy , 2012, Annals of Surgical Oncology.

[12]  Macrophages as potential targets for zoledronic acid outside the skeleton—evidence from in vitro and in vivo models , 2013, Cellular Oncology.

[13]  R. Hoffman,et al.  A new patient‐like metastatic model of human lung cancer constructed orthotopically with intact tissue via thoracotomy in immunodeficient mice , 1992, International journal of cancer.

[14]  I. Holen,et al.  Tumour macrophages as potential targets of bisphosphonates , 2011, Journal of Translational Medicine.

[15]  Alfonso Valencia,et al.  Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment , 2014, Clinical Cancer Research.

[16]  R. Hoffman,et al.  Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Robert M. Hoffman,et al.  Orthotopic Metastatic Mouse Models for Anticancer Drug Discovery and Evaluation: a Bridge to the Clinic , 2004, Investigational New Drugs.

[18]  I. Fidler,et al.  Orthotopic implantation is essential for the selection, growth and metastasis of human renal cell cancer in nude mice [corrected]. , 1990, Cancer metastasis reviews.

[19]  E. Gilpin,et al.  Factors influencing survival after resection for periampullary neoplasms. , 2000, American journal of surgery.

[20]  Davide Corà,et al.  A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. , 2011, Cancer discovery.

[21]  R. Hoffman,et al.  Nude mouse metastatic models of human stomach cancer constructed using orthotopic implantation of histologically intact tissue. , 1993, Cancer research.

[22]  M. Büchler,et al.  Zoledronic Acid has Direct Antiproliferative and Antimetastatic Effect on Pancreatic Carcinoma Cells and Acts as an Antigen for δ2 γ/δ T Cells , 2007, Journal of immunotherapy.

[23]  Meng Yang,et al.  Subcellular imaging in the live mouse , 2006, Nature Protocols.

[24]  Sharmeela Kaushal,et al.  Fluorescently labeled chimeric anti‐CEA antibody improves detection and resection of human colon cancer in a patient‐derived orthotopic xenograft (PDOX) nude mouse model , 2014, Journal of surgical oncology.

[25]  A. Moossa,et al.  Tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer. , 2012, In vivo.

[26]  R. Hoffman,et al.  A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer. , 1993, Anticancer research.

[27]  Yukihiko Hiroshima,et al.  Successful fluorescence-guided surgery on human colon cancer patient-derived orthotopic xenograft mouse models using a fluorophore-conjugated anti-CEA antibody and a portable imaging system. , 2014, Journal of laparoendoscopic & advanced surgical techniques. Part A.

[28]  K. Garber.  From human to mouse and back: 'tumorgraft' models surge in popularity. , 2009, Journal of the National Cancer Institute.

[29]  Jonathan B. Mitchem,et al.  A Study of Zoledronic Acid as Neo-Adjuvant, Perioperative Therapy in Patients with Resectable Pancreatic Ductal Adenocarcinoma. , 2013, Journal of cancer therapy.

[30]  F. Ames,et al.  Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas. , 1992, Archives of surgery.

[31]  D. V. Von Hoff,et al.  Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.