Magnesium and anabolic hormones in older men.

Optimal nutritional and hormonal statuses are determinants of successful ageing. The age associated decline in anabolic hormones such as testosterone and insulin-like growth factor 1 (IGF-1) is a strong predictor of metabolic syndrome, diabetes and mortality in older men. Studies have shown that magnesium intake affects the secretion of total IGF-1 and increase testosterone bioactivity. This observation suggests that magnesium can be a modulator of the anabolic/catabolic equilibrium disrupted in the elderly people. However, the relationship between magnesium and anabolic hormones in men has not been investigated. We evaluated 399 ≥65-year-old men of CHIANTI in a study population representative of two municipalities of Tuscany (Italy) with complete data on testosterone, total IGF-1, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS) and serum magnesium levels. Linear regression models were used to test the relationship between magnesium and testosterone and IGF-1. Mean age of the population was 74.18 ± 6.43 (years ± SD, age range 65.2-92.4). After adjusting for age, magnesium was positively associated with total testosterone (β ± SE, 34.9 ± 10.3; p = 0.001) and with total IGF-1 (β ± SE, 15.9 ± 4.8; p = 0.001). After further adjustment for body mass index (BMI), log (IL-6), log (DHEAS), log (SHBG), log (insulin), total IGF-1, grip strength, Parkinson's disease and chronic heart failure, the relationship between magnesium and total testosterone remained strong and highly significant (β ± SE, 48.72 ± 12.61; p = 0.001). In the multivariate analysis adjusted for age, BMI, log (IL-6), liver function, energy intake, log (insulin), log (DHEAS), selenium, magnesium levels were also still significantly associated with IGF-1 (β ± SE, 16.43 ± 4.90; p = 0.001) and remained significant after adjusting for total testosterone (β ± SE, 14.4 ± 4.9; p = 0.01). In a cohort of older men, magnesium levels are strongly and independently associated with the anabolic hormones testosterone and IGF-1.

[1]  R. Mogulkoc,et al.  Effects of Magnesium Supplementation on Testosterone Levels of Athletes and Sedentary Subjects at Rest and after Exhaustion , 2011, Biological Trace Element Research.

[2]  S. Bandinelli,et al.  Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: the InCHIANTI study. , 2010, Clinical nutrition.

[3]  M. Barbagallo,et al.  Magnesium and aging. , 2010, Current pharmaceutical design.

[4]  L. Fried,et al.  Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the Women's Health and Aging studies. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[5]  C. Champagne.  Magnesium in hypertension, cardiovascular disease, metabolic syndrome, and other conditions: a review. , 2008, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.

[6]  S. Bandinelli,et al.  Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study. , 2007, Archives of internal medicine.

[7]  P. Ponikowski,et al.  Anabolic Deficiency in Men With Chronic Heart Failure: Prevalence and Detrimental Impact on Survival , 2006, Circulation.

[8]  E. Metter,et al.  Decline in insulin-like growth factor-I levels across adult life span in two large population studies. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[9]  S. Bandinelli,et al.  Magnesium and muscle performance in older persons: the InCHIANTI study. , 2006, The American journal of clinical nutrition.

[10]  O. Erel,et al.  The association of total antioxidant capacity with sex hormones , 2005, Scandinavian cardiovascular journal : SCJ.

[11]  Keesook Lee,et al.  Molecular Mechanism of Suppression of Testicular Steroidogenesis by Proinflammatory Cytokine Tumor Necrosis Factor Alpha , 2004, Molecular and Cellular Biology.

[12]  L. Ferrucci,et al.  Inflammation, hormones, and body composition at a crossroad. , 2003, The American journal of medicine.

[13]  E. Rimm,et al.  Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[14]  J. Morley,et al.  Anorexia, sarcopenia, and aging. , 2001, Nutrition.

[15]  G. Ciliberto,et al.  In Vivo Neutralization of Human IL-6 (hIL-6) Achieved by Immunization of hIL-6-Transgenic Mice with a hIL-6 Receptor Antagonist1 , 2001, The Journal of Immunology.

[16]  E. Metter,et al.  Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. , 2001, The Journal of clinical endocrinology and metabolism.

[17]  Luigi Ferrucci,et al.  Subsystems Contributing to the Decline in Ability to Walk: Bridging the Gap Between Epidemiology and Geriatric Practice in the InCHIANTI Study , 2000, Journal of the American Geriatrics Society.

[18]  L. Brilla,et al.  Effects of a Novel Zinc-Magnesium Formulation on Hormones and Strength , 2000 .

[19]  M. Barbagallo,et al.  Magnesium responsiveness to insulin and insulin-like growth factor I in erythrocytes from normotensive and hypertensive subjects. , 1998, The Journal of clinical endocrinology and metabolism.

[20]  S. Mohan,et al.  Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women. , 1998, The American journal of clinical nutrition.

[21]  G. Ciliberto,et al.  Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation. , 1997, The Journal of clinical investigation.

[22]  F Berrino,et al.  Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres. , 1997, International journal of epidemiology.

[23]  T. Phillips,et al.  Immunoregulation by neuropeptides in magnesium deficiency: ex vivo effect of enhanced substance P production on circulating T lymphocytes from magnesium-deficient mice. , 1996, Magnesium research.

[24]  Linda P. Fried,et al.  The Women's Health and Aging Study: Health and Social Characteristics of Older Women with Disability , 1995 .

[25]  W. Carter,et al.  Insulin-like growth factor I as an indicator of protein-energy undernutrition among metabolically stable hospitalized elderly. , 1994, Journal of the American College of Nutrition.

[26]  W. Weglicki,et al.  Magnesium deficiency in vitro enhances free radical‐induced intracellular oxidation and cytotoxicity in endothelial cells , 1992, FEBS letters.

[27]  W. Weglicki,et al.  Erythrocytes from magnesium-deficient hamsters display an enhanced susceptibility to oxidative stress. , 1992, The American journal of physiology.

[28]  R. Elin.  Determination of serum magnesium concentration by clinical laboratories. , 1991, Magnesium and trace elements.