MRI of the cartilage

Abstract. With the introduction of fat-suppressed gradient-echo and fast spin-echo (FSE) sequences in clinical routine MR visualization of the hyaline articular cartilage is routinely possible in the larger joints. While 3D gradient-echo with fat suppression allows exact depiction of the thickness and surface of cartilage, FSE outlines the normal and abnormal internal structures of the hyaline cartilage; therefore, both sequences seem to be necessary in a standard MRI protocol for cartilage visualization. In diagnostically ambiguous cases, in which important therapeutic decisions are required, direct MR arthrography is the established imaging standard as an add-on procedure. Despite the social impact and prevalence, until recent years there was a paucity of knowledge about the pathogenesis of cartilage damage. With the introduction of high-resolution MRI with powerful surface coils and fat-suppression techniques, visualization of the articular cartilage is now routinely possible in many joints. After a short summary of the anatomy and physiology of the hyaline cartilage, the different MR imaging methods are discussed and recommended standards are suggested.

[1]  R. Burgkart,et al.  Precision of tibial cartilage morphometry with a coronal water-excitation MR sequence , 2000, European Radiology.

[2]  Arthur K. Liu The dependence of NMR measured diffusion, magnetization transfer, and T2 relaxation on fractional water content in bovine articular cartilage , 1995 .

[3]  D. Burstein,et al.  Diffusion of small solutes in cartilage as measured by nuclear magnetic resonance (NMR) spectroscopy and imaging , 1993, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[4]  C C Glüer,et al.  Quantification of articular cartilage in the knee with pulsed saturation transfer subtraction and fat-suppressed MR imaging: optimization and validation. , 1994, Radiology.

[5]  D. Burstein,et al.  Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. , 1997, Radiology.

[6]  J A Frank,et al.  Magnetization transfer contrast: MR imaging of the knee. , 1991, Radiology.

[7]  A. Thomas,et al.  Incidental magnetization transfer contrast in fast spin‐echo imaging of cartilage , 1996, Journal of magnetic resonance imaging : JMRI.

[8]  P. Lang,et al.  Magnetresonanztomographie (MRT) des Gelenkknorpels Aktueller Wissensstand und neue Entwicklungen , 2000, Der Radiologe.

[9]  H. Imhof,et al.  Imaging articular cartilage defects with 3D fat-suppressed echo planar imaging: comparison with conventional 3D fat-suppressed gradient echo sequence and correlation with histology. , 1998, Journal of computer assisted tomography.

[10]  D. Burstein,et al.  Magnetization transfer in cartilage and its constituent macromolecules , 1995, Magnetic resonance in medicine.

[11]  L W Jelinski,et al.  Self-diffusion monitors degraded cartilage. , 1995, Archives of biochemistry and biophysics.

[12]  H. Imhof,et al.  The role of relaxation times in monitoring proteoglycan depletion in articular cartilage , 1999, Journal of magnetic resonance imaging : JMRI.

[13]  B. Daenen,et al.  Evaluation of patellar cartilage surface lesions: comparison of CT arthrography and fat-suppressed FLASH 3D MR imaging , 1998, European Radiology.

[14]  Y. Xia,et al.  Magic-Angle Effect in Magnetic Resonance Imaging of Articular Cartilage: A Review , 2000, Investigative radiology.

[15]  J C Gore,et al.  Factors influencing contrast in fast spin-echo MR imaging. , 1992, Magnetic resonance imaging.

[16]  A. Maroudas,et al.  Further studies on the composition of human femoral head cartilage. , 1980, Annals of the rheumatic diseases.

[17]  I. Pataki,et al.  Assessment of cartilage volume in the femorotibial joint with magnetic resonance imaging and 3D computer reconstruction. , 1994, The Journal of rheumatology.

[18]  H. Imhof,et al.  Subchondral Bone and Cartilage Disease: A Rediscovered Functional Unit , 2000, Investigative radiology.

[19]  B. Ingelmark,et al.  Functional thickness variations of human articular cartilage. , 1952, Acta Societatis Medicorum Upsaliensis.

[20]  Bernd Tombach,et al.  Detection of articular cartilage lesions: Experimental evaluation of low‐ and high‐field‐strength MR imaging at 0.18 and 1.0 T , 2000, Journal of magnetic resonance imaging : JMRI.

[21]  K. T. Scott,et al.  Protocol issues for delayed Gd(DTPA)2–‐enhanced MRI (dGEMRIC) for clinical evaluation of articular cartilage , 2001, Magnetic resonance in medicine.

[22]  D Resnick,et al.  Knee hyaline cartilage evaluated with MR imaging: a cadaveric study involving multiple imaging sequences and intraarticular injection of gadolinium and saline solution. , 1991, Radiology.

[23]  V. Mlynárik,et al.  Magnetic resonance imaging of articular cartilage: ex vivo study on normal cartilage correlated with magnetic resonance microscopy , 1998, European Radiology.

[24]  E. Braunstein,et al.  Magnetic resonance imaging of knee hyaline cartilage and intraarticular pathology , 1987, The American journal of sports medicine.

[25]  D. Felsenberg,et al.  Orientation-dependent changes in MR signal intensity of articular cartilage: a manifestation of the “magic angle” effect , 1998, Skeletal Radiology.

[26]  T D Brown,et al.  Finite element studies of some juxtarticular stress changes due to localized subchondral stiffening. , 1984, Journal of biomechanics.

[27]  D G Disler,et al.  Detection of knee hyaline cartilage defects using fat-suppressed three-dimensional spoiled gradient-echo MR imaging: comparison with standard MR imaging and correlation with arthroscopy. , 1995, AJR. American journal of roentgenology.

[28]  M. Reiser,et al.  Assessment of normal patellar cartilage volume and thickness using MRI: an analysis of currently available pulse sequences , 1996, Skeletal Radiology.

[29]  V. Mlynárik,et al.  Physicochemical Properties of Normal Articular Cartilage and Its MR Appearance , 2000, Investigative radiology.

[30]  J. B. Kneeland,et al.  Quantification of the volume of articular cartilage in the metacarpophalangeal joints of the hand: accuracy and precision of three-dimensional MR imaging. , 1995, AJR. American journal of roentgenology.

[31]  D. Burstein,et al.  Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI , 1999, Magnetic resonance in medicine.

[32]  D. Burstein,et al.  Gd‐DTPA2− as a measure of cartilage degradation , 1996, Magnetic resonance in medicine.

[33]  A. Engel Magnetic resonance knee arthrography. Enhanced contrast by gadolinium complex in the rabbit and in humans. , 1990, Acta orthopaedica Scandinavica. Supplementum.

[34]  B E Bouma,et al.  High resolution imaging of normal and osteoarthritic cartilage with optical coherence tomography. , 1999, The Journal of rheumatology.

[35]  W E Garrett,et al.  Magnetic resonance imaging of traumatic knee articular cartilage injuries , 1991, The American journal of sports medicine.

[36]  J Romero,et al.  MRI of patellar articular cartilage: Evaluation of an optimized gradient‐echo sequence (3D‐DESS) , 1998, Journal of magnetic resonance imaging : JMRI.

[37]  H K Genant,et al.  MR imaging of the arthritic knee: improved discrimination of cartilage, synovium, and effusion with pulsed saturation transfer and fat-suppressed T1-weighted sequences. , 1994, Radiology.

[38]  T. McCauley,et al.  Chondromalacia patellae: diagnosis with MR imaging. , 1992, AJR. American journal of roentgenology.

[39]  F Eckstein,et al.  Magnetic resonance chondro‐crassometry (MR CCM): A method for accurate determination of articular cartilace thickness? , 1996, Magnetic resonance in medicine.

[40]  S Trattnig,et al.  MRI visualization of proteoglycan depletion in articular cartilage via intravenous administration of Gd-DTPA. , 1999, Magnetic resonance imaging.

[41]  D Resnick,et al.  Abnormalities of articular cartilage in the knee: analysis of available MR techniques. , 1993, Radiology.

[42]  S. Erickson,et al.  Hyaline cartilage: truncation artifact as a cause of trilaminar appearance with fat-suppressed three-dimensional spoiled gradient-recalled sequences. , 1996, Radiology.

[43]  D W Piraino,et al.  Accuracy of fat-suppressed three-dimensional spoiled gradient-echo FLASH MR imaging in the detection of patellofemoral articular cartilage abnormalities. , 1996, Radiology.

[44]  F Eckstein,et al.  In vivo reproducibility of three-dimensional cartilage volume and thickness measurements with MR imaging. , 1998, AJR. American journal of roentgenology.

[45]  F Eckstein,et al.  A non-invasive technique for 3-dimensional assessment of articular cartilage thickness based on MRI. Part 1: Development of a computational method. , 1997, Magnetic resonance imaging.

[46]  W. F. Conway,et al.  Evaluation of articular cartilage: radiographic and cross-sectional imaging techniques. , 1992, Radiographics : a review publication of the Radiological Society of North America, Inc.

[47]  V. Jellús,et al.  Short-TE projection reconstruction MR microscopy in the evaluation of articular cartilage thickness , 2000, European Radiology.

[48]  D J Mikulis,et al.  Quantitation of articular cartilage using magnetic resonance imaging and three‐dimensional reconstruction , 1995, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[49]  D Resnick,et al.  Knee Joint Hyaline Cartilage Defects: A Comparative Study of MR and Anatomic Sections , 1992, Journal of computer assisted tomography.