Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2′dG

In a randomized, double-blind, placebo-controlled study in 64 subjects with Huntington disease (HD), 8 g/day of creatine administered for 16 weeks was well tolerated and safe. Serum and brain creatine concentrations increased in the creatine-treated group and returned to baseline after washout. Serum 8-hydroxy-2′-deoxyguanosine (8OH2′dG) levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by creatine treatment.

[1]  S. Swinnen,et al.  Creatine supplementation in Huntington’s disease , 2003, Neurology.

[2]  M. Beal,et al.  A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2'-deoxyguanosine measurements in urine and other biologic matrices: a one-year evaluation of methods. , 1999, Free radical biology & medicine.

[3]  A. Blamire,et al.  Creatine therapy for Huntington’s disease: Clinical and MRS findings in a 1-year pilot study , 2003, Neurology.

[4]  B R Rosen,et al.  Non-Invasive Neurochemical Analysis of Focal Excitotoxic Lesions in Models of Neurodegenerative Illness Using Spectroscopic Imaging , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[5]  M. Beal,et al.  Increased oxidative damage to DNA in ALS patients. , 2000, Free radical biology & medicine.

[6]  O. Andreassen,et al.  Creatine Increases Survival and Delays Motor Symptoms in a Transgenic Animal Model of Huntington's Disease , 2001, Neurobiology of Disease.

[7]  O. Andreassen,et al.  Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. , 2001, Neurobiology of disease.

[8]  J. Dichgans,et al.  Oxidative stress in patients with Friedreich ataxia , 2000, Neurology.

[9]  Ole A. Andreassen,et al.  Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease , 2000, The Journal of Neuroscience.

[10]  S. Hersch,et al.  Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice , 2003, Journal of neurochemistry.