Genetic prediction of common diseases. Still no help for the clinical diabetologist!

[1]  Jaeil Ahn,et al.  Testing gene-environment interaction in large-scale case-control association studies: possible choices and comparisons. , 2012, American journal of epidemiology.

[2]  Juan Pablo Lewinger,et al.  Invited commentary: GE-Whiz! Ratcheting gene-environment studies up to the whole genome and the whole exposome. , 2012, American journal of epidemiology.

[3]  Jaeil Ahn,et al.  Mukherjee et al. Respond to “GE-Whiz! Ratcheting Up Gene-Environment Studies” , 2012 .

[4]  Peter Kraft,et al.  Gene-environment interactions in genome-wide association studies: a comparative study of tests applied to empirical studies of type 2 diabetes. , 2012, American journal of epidemiology.

[5]  Nancy R Cook,et al.  Comments on ‘Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers’ by M. J. Pencina, R. B. D'Agostino, Sr. and E. W. Steyerberg , 2012, Statistics in medicine.

[6]  F. Hu,et al.  Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies. , 2011, Journal of the American College of Cardiology.

[7]  D. Bick,et al.  Whole Exome and Whole Genome Sequencing – Community Plan Medical Policy , 2018 .

[8]  R. Giacco,et al.  Whole grain intake in relation to body weight: from epidemiological evidence to clinical trials. , 2011, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[9]  P. Piatti,et al.  Consensus on: Screening and therapy of coronary heart disease in diabetic patients. , 2011, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[10]  H. Kolb,et al.  Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism--the Finnish Diabetes Prevention Study. , 2011, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[11]  L. Groop,et al.  Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study , 2011, Diabetologia.

[12]  R. Luben,et al.  Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease , 2011, Diabetologia.

[13]  N. Mehta.  Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. , 2011, Circulation. Cardiovascular genetics.

[14]  Christine Hauskeller,et al.  Direct to consumer genetic testing , 2011, BMJ : British Medical Journal.

[15]  J. Ioannidis,et al.  Strengthening the reporting of genetic risk prediction studies: the GRIPS statement , 2011, Genetics in Medicine.

[16]  Mark I. McCarthy,et al.  A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease , 2011, Nature Genetics.

[17]  Ewout W Steyerberg,et al.  Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers , 2011, Statistics in medicine.

[18]  Mark I McCarthy,et al.  Genomics, type 2 diabetes, and obesity. , 2010, The New England journal of medicine.

[19]  Pascal Borry,et al.  Statement of the ESHG on direct-to-consumer genetic testing for health-related purposes , 2010, European Journal of Human Genetics.

[20]  L. Peltonen,et al.  A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses , 2010, The Lancet.

[21]  Richard W. Grant,et al.  Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms , 2010, Diabetes Care.

[22]  D. Altshuler,et al.  A map of human genome variation from population-scale sequencing , 2010, Nature.

[23]  D. Goldstein,et al.  Uncovering the roles of rare variants in common disease through whole-genome sequencing , 2010, Nature Reviews Genetics.

[24]  Euan A Ashley,et al.  Challenges in the clinical application of whole-genome sequencing , 2010, The Lancet.

[25]  Heather Skirton,et al.  Genetic education and the challenge of genomic medicine: development of core competences to support preparation of health professionals in Europe , 2010, European Journal of Human Genetics.

[26]  D. Thomas,et al.  Gene–environment-wide association studies: emerging approaches , 2010, Nature Reviews Genetics.

[27]  S. Humphries,et al.  Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study , 2010, BMJ : British Medical Journal.

[28]  M. Khoury,et al.  Personal genomics: information can be harmful , 2010, European journal of clinical investigation.

[29]  V. Trischitta,et al.  Insulin signaling regulating genes: effect on T2DM and cardiovascular risk , 2009, Nature Reviews Endocrinology.

[30]  Judy H. Cho,et al.  Finding the missing heritability of complex diseases , 2009, Nature.

[31]  J. Florez,et al.  The clinical application of genetic testing in type 2 diabetes: a patient and physician survey , 2009, Diabetologia.

[32]  N. Abate,et al.  IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of ‘low-frequency–low-risk’ variants , 2009, Diabetologia.

[33]  K. Frazer,et al.  Common vs. rare allele hypotheses for complex diseases. , 2009, Current opinion in genetics & development.

[34]  Tianxi Cai,et al.  Joint Effects of Common Genetic Variants on the Risk for Type 2 Diabetes in U.S. Men and Women of European Ancestry , 2009, Annals of Internal Medicine.

[35]  Daniel F. Schwarz,et al.  New susceptibility locus for coronary artery disease on chromosome 3q22.3 , 2009, Nature Genetics.

[36]  Benjamin J. Wright,et al.  Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease , 2009, Nature Genetics.

[37]  Alberto Piazza,et al.  Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants , 2009, Nature Genetics.

[38]  M. McCarthy,et al.  Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data , 2009, Diabetes.

[39]  F. Hu,et al.  Interaction between poor glycemic control and 9p21 locus on risk of coronary artery disease in type 2 diabetes. , 2008, JAMA.

[40]  R. D'Agostino,et al.  Genotype score in addition to common risk factors for prediction of type 2 diabetes. , 2008, The New England journal of medicine.

[41]  B. Maher.  Personal genomes: The case of the missing heritability , 2008, Nature.

[42]  A. Cecile J.W. Janssens,et al.  Predicting Type 2 Diabetes Based on Polymorphisms From Genome-Wide Association Studies , 2008, Diabetes.

[43]  Cornelia M van Duijn,et al.  Genome-based prediction of common diseases: advances and prospects. , 2008, Human molecular genetics.

[44]  M. Schulze,et al.  Whole-grain consumption and transcription factor-7-like 2 (TCF7L2) rs7903146: gene–diet interaction in modulating type 2 diabetes risk , 2008, British Journal of Nutrition.

[45]  M. Permutt,et al.  Post Genome-Wide Association Studies of Novel Genes Associated with Type 2 Diabetes Show Gene-Gene Interaction and High Predictive Value , 2008, PloS one.

[46]  Muin J Khoury,et al.  A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions. , 2008, American journal of human genetics.

[47]  M. Pencina,et al.  Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond , 2008, Statistics in medicine.

[48]  C. Dina,et al.  Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study , 2008, Diabetes.

[49]  Kari Stefansson,et al.  A common variant on chromosome 9p21 affects the risk of myocardial infarction. , 2007, Science.

[50]  C. Gieger,et al.  Genomewide association analysis of coronary artery disease. , 2007, The New England journal of medicine.

[51]  Jonathan C. Cohen,et al.  A Common Allele on Chromosome 9 Associated with Coronary Heart Disease , 2007, Science.

[52]  N. Cook.  Use and Misuse of the Receiver Operating Characteristic Curve in Risk Prediction , 2007, Circulation.

[53]  F. Turchi,et al.  The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy. , 2005, Diabetes.

[54]  E. Lander,et al.  Finishing the euchromatic sequence of the human genome , 2004 .

[55]  J. Bonfield,et al.  Finishing the euchromatic sequence of the human genome , 2004, Nature.

[56]  M. Stoll,et al.  High incidence of type 2 diabetes in peroxisome proliferator-activated receptor gamma2 Pro12Ala carriers exposed to a high chronic intake of trans fatty acids and saturated fatty acids. , 2004, Diabetes care.

[57]  C. Langefeld,et al.  Heritability of Carotid Artery Intima-Medial Thickness in Type 2 Diabetes , 2002, Stroke.

[58]  A. Krolewski,et al.  Risk of diabetes in siblings of index cases with Type 2 diabetes: implications for genetic studies , 2002, Diabetic medicine : a journal of the British Diabetic Association.

[59]  E. Lander,et al.  On the allelic spectrum of human disease. , 2001, Trends in genetics : TIG.

[60]  C. Langefeld,et al.  Familial aggregation of coronary artery calcium in families with type 2 diabetes. , 2001, Diabetes.

[61]  D. Accili,et al.  The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells. , 2000, The Journal of clinical endocrinology and metabolism.

[62]  G Scarlato,et al.  A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. , 1999, Diabetes.

[63]  J. Sowers,et al.  Diabetes and cardiovascular disease. , 1999, Diabetes care.

[64]  M. Stern.  Diabetes and Cardiovascular Disease: The “Common Soil” Hypothesis , 1995, Diabetes.

[65]  L. Berkman,et al.  Genetic susceptibility to death from coronary heart disease in a study of twins. , 1994, The New England journal of medicine.

[66]  M. King,et al.  Concordance for Type 2 (non-insulin-dependent) diabetes mellitus in male twins , 1987, Diabetologia.

[67]  Medicina Legale,et al.  La Genomica in Sanità Pubblica , 2012 .

[68]  M. Metzker.  Sequencing technologies — the next generation , 2010, Nature Reviews Genetics.

[69]  K. Narayan,et al.  Clinical risk factors, DNA variants, and the development of type 2 diabetes. , 2009, The New England journal of medicine.

[70]  International Human Genome Sequencing Consortium.  Finishing the euchromatic sequence of the human genome , 2004 .