Pathological gambling and mood disorders: clinical associations and treatment implications.

BACKGROUND The rapidly expanding gambling business has resulted in an increasing number of gamblers, and the problem is likely to get worse in the future. Traditionally, mood and gambling symptoms have been known to overlap. In the present review we attempt to examine the diagnostic associations and implications for treatment. METHOD Selected published papers on the frequencies of mood disorders among patients who have gambling disorder or gambling disorder among patients who have mood disorder have been reviewed. Recently emerging new treatment methods for gambling disorder have been reviewed and a brief summary has been added. RESULTS SCID based study results show a close link between gambling and mood disorders. The prevalence of manic disorder reaches to approximately one fourth of the pathological gambling disorder population. The prevalence of depression is much higher, reaching to over half of the population in some studies. LIMITATIONS The studies included in the present paper involve inpatients, outpatients, subjects recruited through advertisements and prison populations. Thus the data need to be interpreted as such. Standardized assessment instruments are not used in all studies. Methodological issues such as primary or secondary nature of depression have not been addressed adequately in these studies. The findings, however, offer new insights for the assessment and treatment of complicated gambling disorder cases. CONCLUSIONS A high prevalence rate of manic and depressive disorders has been recorded among pathological gambling disorder patients. A rational treatment approach to each defined subset of complicated gambling disorder is discussed.

[1]  P. Santonastaso,et al.  Suicidality in eating disorders: clinical and psychological correlates , 1997, Acta psychiatrica Scandinavica.

[2]  M. Raichle,et al.  Neural correlates of self-induced dysphoria. , 1993, The American journal of psychiatry.

[3]  Suck-Won Kim,et al.  Demographic and clinical features of 131 adult pathological gamblers. , 2001, The Journal of clinical psychiatry.

[4]  Suck-Won Kim,et al.  Pharmacotherapy of pathological gambling , 2002 .

[5]  John C Gore,et al.  Gambling urges in pathological gambling: a functional magnetic resonance imaging study. , 2003, Archives of general psychiatry.

[6]  J. Adès,et al.  Impulse Control Disorders and Depression , 2002, The Journal of nervous and mental disease.

[7]  T. Reich,et al.  MANIC DEPRESSIVE ILLNESS , 1984, The Lancet.

[8]  E. Hollander,et al.  Nefazodone treatment of pathological gambling: a prospective open-label controlled trial. , 2002, The Journal of clinical psychiatry.

[9]  M. Raichle,et al.  Subgenual prefrontal cortex abnormalities in mood disorders , 1997, Nature.

[10]  R. Goldstein,et al.  Compulsive behaviors and obsessive-compulsive disorder (OCD): lack of a relationship between OCD, eating disorders, and gambling. , 1994, Comprehensive psychiatry.

[11]  D. Black,et al.  Clinical features and psychiatric comorbidity of subjects with pathological gambling behavior. , 1998, Psychiatric services.

[12]  J. Volpicelli Uncontrollable events and alcohol drinking. , 1987, British journal of addiction.

[13]  F. Goodwin Manic-Depressive Illness , 1990 .

[14]  P. Keck,et al.  The DSM-III-R impulse control disorders not elsewhere classified: clinical characteristics and relationship to other psychiatric disorders. , 1992, The American journal of psychiatry.

[15]  E. Rolls,et al.  Abstract reward and punishment representations in the human orbitofrontal cortex , 2001, Nature Neuroscience.

[16]  M J Goldman,et al.  Kleptomania: making sense of the nonsensical. , 1991, The American journal of psychiatry.

[17]  Ronald J. Faber,et al.  Compulsive buying: descriptive characteristics and psychiatric comorbidity. , 1994, The Journal of clinical psychiatry.

[18]  S. Strakowski,et al.  Chronology of comorbid and principal syndromes in first-episode psychosis. , 1995, Comprehensive psychiatry.

[19]  J. Missimer,et al.  Reward mechanisms in the brain and their role in dependence: evidence from neurophysiological and neuroimaging studies , 2001, Brain Research Reviews.

[20]  D. Dougherty,et al.  Measurement of inter-episode impulsivity in bipolar disorder , 2001, Psychiatry Research.

[21]  Moskowitz Ja Lithium and lady luck; use of lithium carbonate in compulsive gambling. , 1980 .

[22]  P. Skudlarski,et al.  An Fmri Stroop Task Study of Ventromedial Prefrontal Cortical Function in Pathological Gamblers Image Acquisition , 2022 .

[23]  H. Akiskal,et al.  The soft bipolar spectrum redefined: focus on the cyclothymic, anxious-sensitive, impulse-dyscontrol, and binge-eating connection in bipolar II and related conditions. , 2002, The Psychiatric clinics of North America.

[24]  C. Blanco,et al.  Psychiatric comorbidity in pathological gamblers seeking treatment. , 2001, The American journal of psychiatry.

[25]  H. Hinterhuber,et al.  Treatment of Pathological Gambling with Carbamazepine , 1994, Pharmacopsychiatry.

[26]  K. Phillips,et al.  Are impulse-control disorders related to bipolar disorder? , 1996, Comprehensive psychiatry.

[27]  H. Pope,et al.  Pathological gambling and major affective disorder: preliminary findings. , 1986, The Journal of clinical psychiatry.

[28]  A. Alterman,et al.  Naltrexone and the Treatment of Alcohol-Dependence: Initial Observations , 1990 .

[29]  C. McDougle,et al.  Potential of Atypical Antipsychotics in the Treatment of Nonpsychotic Disorders , 1998 .

[30]  Helen S Mayberg,et al.  Modulating limbic-cortical circuits in depression: targets of antidepressant treatments. , 2002, Seminars in clinical neuropsychiatry.

[31]  M. Kreek Opiates, opioids and addiction. , 1996, Molecular psychiatry.

[32]  S. Strakowski,et al.  Outcome and Comorbidity in First- Compared with Multiple‐Episode Mania , 1995, The Journal of nervous and mental disease.

[33]  J. Thorson,et al.  Epidemiology of Gambling and Depression in an Adult Sample , 1994, Psychological reports.

[34]  E. Becoña,et al.  Pathological Gambling and Depression , 1996, Psychological reports.

[35]  K. Jamison,et al.  Touched with fire : manic-depressive illness and the artistic temperament , 1993 .

[36]  Suck-Won Kim,et al.  Comorbidity of impulse control disorders in pathological gamblers , 2003, Acta psychiatrica Scandinavica.

[37]  W. Drevets Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression. , 2000, Progress in brain research.

[38]  Suck-Won Kim,et al.  Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling , 2001, Biological Psychiatry.

[39]  J. Grant,et al.  The psychopharmacology of pathological gambling. , 2001, Seminars in clinical neuropsychiatry.

[40]  K. Phillips,et al.  Kleptomania, compulsive buying, and binge-eating disorder. , 1995, The Journal of clinical psychiatry.

[41]  S. Strakowski,et al.  Differences and similarities in mixed and pure mania. , 1995, Comprehensive psychiatry.

[42]  R. McCormick,et al.  Affective disorders among pathological gamblers seeking treatment. , 1984, The American journal of psychiatry.

[43]  V. Lorenz,et al.  Depressed pathological gamblers , 1988, Acta psychiatrica Scandinavica.