Triple-Poles Complementary Split Ring Resonator for Sensing Diabetics Glucose Levels at cm-Band

Microwave sensors are very promising for sensing the blood glucose levels non-invasively for their non-ionizing nature, miniaturized sizing, and low health risks for diabetics. All these features offer the possibility for realizing a portable non-invasive glucose sensor for monitoring glucose levels in real time. In this article, we propose a triple poles complementary split ring resonator (CSRR) produced on a FR4 substrate in microstrip technology in the cm-wave band (1-6 GHz). The proposed bio-sensor can detect the small variations in the dielectric properties (relative permittivity and dielectric losses) of glucose in the blood mimicking aqueous solutions due their intense interaction with the electromagnetic field at harmonic resonances. The resonator exhibits higher sensitivity performance at the different resonances compared to the single and double-poles counterparts as demonstrated by simulations in a 3D full-wave EM solver.

[1]  A. Karter,et al.  Self-monitoring of blood glucose: language and financial barriers in a managed care population with diabetes. , 2000, Diabetes care.

[2]  Derek Abbott,et al.  Dual-mode behavior of the complementary electric-LC resonators loaded on transmission line: Analysis and applications , 2014 .

[3]  S. Tungjitkusolmun,et al.  Real-time monitoring glucose by used microwave antenna apply to biosensor , 2012, The 4th 2011 Biomedical Engineering International Conference.

[4]  P. Domich,et al.  Analysis of an open-ended coaxial probe with lift-off for nondestructive testing , 1994 .

[6]  Shaojin Wang,et al.  Permittivity and Measurements , 2005 .

[7]  R. Wu,et al.  Blood glucose monitoring using microwave cavity perturbation , 2012 .

[8]  Margaret McCann,et al.  Fundamentals of Medical-Surgical Nursing: A Systems Approach , 2014 .

[9]  Kammel Rachedi,et al.  Improved microwave biosensor for non-invasive dielectric characterization of biological tissues , 2018, Microelectron. J..

[10]  R. Weigel,et al.  A microwave sensing system for aqueous concentration measurements based on a microwave reflectometer , 2012, 2012 IEEE/MTT-S International Microwave Symposium Digest.

[11]  J. Shaw,et al.  IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. , 2011, Diabetes research and clinical practice.

[12]  Clive Parini,et al.  Detection of glucose variability in saline solutions from transmission and reflection measurements using V-band waveguides , 2015 .

[13]  Dustin G. Mixon,et al.  Electromagnetic properties of tissue in the optical region , 2007, SPIE BiOS.

[14]  Chin-Lung Yang,et al.  Complementary Split-Ring Resonators for Measuring Dielectric Constants and Loss Tangents , 2014, IEEE Microwave and Wireless Components Letters.

[15]  Irl B. Hirsch,et al.  1. Self-Monitoring of Blood Glucose , 2012 .

[16]  Paul McArthur,et al.  Numerical analysis of open-ended coaxial line probes and its application to in-vivo dielectric measurements , 1989 .

[17]  G. Rossi,et al.  Diagnosis and Classification of Diabetes Mellitus The information that follows is based largely on the reports of the Expert Committee on the Diagnosis and Classification of Diabetes (Diabetes Care 20:1183–1197, 1997, and Diabetes Care 26:3160–3167, 2003). , 2008, Diabetes Care.

[18]  Omar M. Ramahi,et al.  Material Characterization Using Complementary Split-Ring Resonators , 2012, IEEE Transactions on Instrumentation and Measurement.

[19]  A. Porch,et al.  Design and In Vitro Interference Test of Microwave Noninvasive Blood Glucose Monitoring Sensor , 2015, IEEE Transactions on Microwave Theory and Techniques.

[20]  Dietmar Kissinger,et al.  Microwave-Based Noninvasive Concentration Measurements for Biomedical Applications , 2013, IEEE Transactions on Microwave Theory and Techniques.

[21]  Weilian Wang,et al.  Testing glucose concentration in aqueous solution based on microwave cavity perturbation technique , 2010, 2010 3rd International Conference on Biomedical Engineering and Informatics.

[22]  R. Weigel,et al.  Non-invasive glucose monitoring using open electromagnetic waveguides , 2012, 2012 42nd European Microwave Conference.

[23]  J. Shaw,et al.  IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. , 2011, Diabetes research and clinical practice.

[24]  Kiejin Lee,et al.  Microwave dielectric resonator biosensor for aqueous glucose solution. , 2008, The Review of scientific instruments.

[25]  Dietmar Kissinger,et al.  A novel approach to non-invasive blood glucose measurement based on RF transmission , 2011, 2011 IEEE International Symposium on Medical Measurements and Applications.

[26]  Tutku Karacolak,et al.  Cole–cole model for glucose‐dependent dielectric properties of blood plasma for continuous glucose monitoring , 2013 .

[27]  Izzet Kale,et al.  On the accuracy of complex permittivity model of glucose/water solutions for non-invasive microwave blood glucose sensing , 2015, 2015 E-Health and Bioengineering Conference (EHB).