Self-tracking Energy Transfer for Neural Stimulation in Untethered Mice

Optical or electrical stimulation of neural circuits in mice during natural behavior is an important paradigm for studying brain function. Conventional systems for optogenetics and electrical microstimulation require tethers or large head-mounted devices that disrupt animal behavior. We report a method for wireless powering of small-scale implanted devices based on the strong localization of energy that occurs during resonant interaction between a radio-frequency cavity and intrinsic modes in mice. The system features self-tracking over a wide (16 cm diameter) operational area, and is used to demonstrate wireless activation of cortical neurons with miniaturized stimulators (10 mm$^{3}$, 20 mg) fully implanted under the skin.

[1]  T. Curran,et al.  Expression of c-fos protein in brain: metabolic mapping at the cellular level. , 1988, Science.

[2]  Ieee Standards Board.  IEEE standard for safety levels with respect to human exposure to radio frequency electromagnetic fields, 3kHz to 300 GHz , 1992 .

[3]  R. W. Lau,et al.  The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues. , 1996, Physics in medicine and biology.

[4]  Andrew G. Glen,et al.  APPL , 2001 .

[5]  Shennan A. Weiss,et al.  Rat navigation guided by remote control , 2002 .

[6]  J. Sambles,et al.  Resonant transmission of microwaves through a narrow metallic slit. , 2002, Physical review letters.

[7]  P. Kam,et al.  : 4 , 1898, You Can Cross the Massacre on Foot.

[8]  Ericka Stricklin-Parker,et al.  Ann , 2005 .

[9]  P. Sheng,et al.  Resonant transmission of microwaves through subwavelength fractal slits in a metallic plate , 2005 .

[10]  Feng Zhang,et al.  An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology , 2007, Journal of neural engineering.

[11]  M. Soljačić,et al.  Wireless Power Transfer via Strongly Coupled Magnetic Resonances , 2007, Science.

[12]  Scott K. Arfin,et al.  Wireless neural stimulation in freely behaving small animals. , 2009, Journal of neurophysiology.

[13]  R. Rosenfeld.  Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[14]  J. Price,et al.  Neurocircuitry of Mood Disorders , 2010, Neuropsychopharmacology.

[15]  Naoshige Uchida,et al.  A wireless multi-channel neural amplifier for freely moving animals , 2011, Nature Neuroscience.

[16]  David R. Smith,et al.  Metamaterial-enhanced coupling between magnetic dipoles for efficient wireless power transfer , 2011, 1102.2281.

[17]  S. Fan,et al.  Wireless energy transfer with the presence of metallic planes , 2011 .

[18]  P. Irazoqui,et al.  Wireless Powering and the Study of RF Propagation Through Ocular Tissue for Development of Implantable Sensors , 2011, IEEE Transactions on Antennas and Propagation.

[19]  Alex Rodriguez,et al.  A wirelessly powered and controlled device for optical neural control of freely-behaving animals , 2011, Journal of neural engineering.

[20]  D. Denys,et al.  [Deep brain stimulation for psychiatric disorders]. , 2013, Nederlands tijdschrift voor geneeskunde.

[21]  Steffen B. E. Wolff,et al.  A polymer-based neural microimplant for optogenetic applications: design and first in vivo study. , 2013, Lab on a chip.

[22]  A. Poon,et al.  Midfield wireless powering of subwavelength autonomous devices. , 2013, Physical review letters.

[23]  Yei Hwan Jung,et al.  Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics , 2013, Science.

[24]  A. Poon,et al.  Wirelessly powering miniature implants for optogenetic stimulation , 2013 .

[25]  John A Rogers,et al.  Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics , 2013, Nature Protocols.

[26]  K. Deisseroth.  Circuit dynamics of adaptive and maladaptive behaviour , 2014, Nature.

[27]  P. Irazoqui,et al.  Ultrasmall Integrated 3D Micro‐Supercapacitors Solve Energy Storage for Miniature Devices , 2014 .

[28]  Hajime Hirase,et al.  Programmable wireless light-emitting diode stimulator for chronic stimulation of optogenetic molecules in freely moving mice , 2014, Neurophotonics.

[29]  Maysam Ghovanloo,et al.  EnerCage: A Smart Experimental Arena With Scalable Architecture for Behavioral Experiments , 2014, IEEE Transactions on Biomedical Engineering.

[30]  Thi Kim Thoa Nguyen,et al.  Closed-loop optical neural stimulation based on a 32-channel low-noise recording system with online spike sorting , 2014, Journal of neural engineering.

[31]  Jessica A. Cardin,et al.  Optical neural interfaces. , 2014, Annual review of biomedical engineering.