Epitope mapping of nanobodies binding the Alzheimer's disease receptor SORLA.

[1]  G. Petsko,et al.  Dimerization of the Alzheimer’s disease pathogenic receptor SORLA regulates its association with retromer , 2023, Proceedings of the National Academy of Sciences of the United States of America.

[2]  B. Erman,et al.  Nanobodies as molecular imaging probes. , 2022, Free radical biology & medicine.

[3]  S. Muyldermans,et al.  Application of Single-Domain Antibodies (“Nanobodies”) to Laboratory Diagnosis , 2021, Annals of laboratory medicine.

[4]  D. Campion,et al.  Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease , 2021, Acta Neuropathologica Communications.

[5]  S. Lincoln,et al.  Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer’s disease , 2021, Acta neuropathologica communications.

[6]  Jun Zhao,et al.  Nanobody: a promising toolkit for molecular imaging and disease therapy , 2021, EJNMMI Research.

[7]  D. Goldstein,et al.  Whole‐exome sequencing in 20,197 persons for rare variants in Alzheimer's disease , 2018, Annals of clinical and translational neurology.

[8]  W. M. van der Flier,et al.  Characterization of pathogenic SORL1 genetic variants for association with Alzheimer’s disease: a clinical interpretation strategy , 2017, European Journal of Human Genetics.

[9]  T. Willnow,et al.  Risk factor SORL1: from genetic association to functional validation in Alzheimer’s disease , 2016, Acta Neuropathologica.

[10]  Lei Shao,et al.  Nanobody-derived nanobiotechnology tool kits for diverse biomedical and biotechnology applications , 2016, International journal of nanomedicine.

[11]  Giuliano Binetti,et al.  A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer’s disease , 2016, Acta Neuropathologica.

[12]  Mark Bates,et al.  Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation , 2015, eLife.

[13]  D. Ecker,et al.  The therapeutic monoclonal antibody market , 2015, mAbs.

[14]  G. Larson,et al.  SorLA Complement-type Repeat Domains Protect the Amyloid Precursor Protein against Processing* , 2014, The Journal of Biological Chemistry.

[15]  Serge Muyldermans,et al.  Nanobodies: natural single-domain antibodies. , 2013, Annual review of biochemistry.

[16]  S. Muyldermans,et al.  Nanobodies and their potential applications. , 2013, Nanomedicine.

[17]  Seppo Ylä-Herttuala,et al.  Challenges in monoclonal antibody-based therapies , 2009, Annals of medicine.

[18]  K. Lunetta,et al.  The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease , 2007, Nature Genetics.

[19]  Vanessa Schmidt,et al.  Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. , 2006, Biochemistry.

[20]  B. Hyman,et al.  Interaction of the Cytosolic Domains of sorLA/LR11 with the Amyloid Precursor Protein (APP) and β-Secretase β-Site APP-Cleaving Enzyme , 2006, The Journal of Neuroscience.

[21]  B. Hyman,et al.  Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[22]  P. Madsen,et al.  Activation and Functional Characterization of the Mosaic Receptor SorLA/LR11* , 2001, The Journal of Biological Chemistry.

[23]  N. Tommerup,et al.  Molecular Characterization of a Novel Human Hybrid-type Receptor That Binds the α2-Macroglobulin Receptor-associated Protein* , 1996, The Journal of Biological Chemistry.

[24]  S. Muyldermans,et al.  Naturally occurring antibodies devoid of light chains , 1993, Nature.

[25]  S. Muyldermans,et al.  Construction of High-Quality Camel Immune Antibody Libraries. , 2018, Methods in molecular biology.

[26]  S. Muyldermans,et al.  Generation of single domain antibody fragments derived from camelids and generation of manifold constructs. , 2012, Methods in molecular biology.

[27]  D. Selkoe.  Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.