Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit.

Transforming growth factor-β (TGF-β) superfamily members regulate a wide range of biological processes by binding to two transmembrane serine/threonine kinase receptors, type I and type II. We have...

[1]  Y. Henis,et al.  Lateral diffusion and patch formation of H-2Kk antigens on mouse spleen lymphocytes. , 1983, Biochimica et biophysica acta.

[2]  S. Schmid,et al.  Clathrin-coated vesicle formation and protein sorting: an integrated process. , 1997, Annual review of biochemistry.

[3]  J. Massagué,et al.  Controlling TGF-β signaling , 2000, Genes & Development.

[4]  Y. Henis,et al.  A single internalization signal from the di-leucine family is critical for constitutive endocytosis of the type II TGF-beta receptor. , 2001, Journal of cell science.

[5]  M. Robinson,et al.  Targeting signals and subunit interactions in coated vesicle adaptor complexes , 1995, The Journal of cell biology.

[6]  M. Marks,et al.  Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores. , 1997, Trends in cell biology.

[7]  R. Kurten,et al.  Association of Epidermal Growth Factor Receptors with Coated Pit Adaptins via a Tyrosine Phosphorylation-regulated Mechanism (*) , 1995, The Journal of Biological Chemistry.

[8]  C. Waters,et al.  Endocytosis of growth factor receptors , 1993, BioEssays : news and reviews in molecular, cellular and developmental biology.

[9]  R. A. Warren,et al.  Distinct Saturable Pathways for the Endocytosis of Different Tyrosine Motifs* , 1998, The Journal of Biological Chemistry.

[10]  L. Cantley,et al.  Regulatory interactions in the recognition of endocytic sorting signals by AP‐2 complexes , 1997, The EMBO journal.

[11]  J. Doré,et al.  Mechanisms of transforming growth factor-beta receptor endocytosis and intracellular sorting differ between fibroblasts and epithelial cells. , 2001, Molecular biology of the cell.

[12]  H. Lodish,et al.  Oligomeric Structure of Type I and Type II Transforming Growth Factor β Receptors: Homodimers Form in the ER and Persist at the Plasma Membrane , 1998, The Journal of cell biology.

[13]  B. Deurs,et al.  Clathrin and HA2 adaptors: effects of potassium depletion, hypertonic medium, and cytosol acidification , 1993, The Journal of cell biology.

[14]  Pier Paolo Di Fiore,et al.  Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis , 1998, Nature.

[15]  D. Fremont,et al.  Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[16]  A. Dautry‐Varsat,et al.  The Ear of -Adaptin Interacts with the COOH-terminal Domain of the Eps15 Protein (*) , 1996, The Journal of Biological Chemistry.

[17]  J. Wrana Regulation of Smad Activity , 2000, Cell.

[18]  M. Greenberg,et al.  A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4 , 1998, Current Biology.

[19]  J. Bonifacino,et al.  Molecular Bases for the Recognition of Tyrosine-based Sorting Signals , 1999, The Journal of cell biology.

[20]  T. Kirchhausen,et al.  A Clathrin-binding Site in the Hinge of the 2 Chain of Mammalian AP-2 Complexes (*) , 1995, The Journal of Biological Chemistry.

[21]  J. Bonifacino,et al.  Sequence requirements for the recognition of tyrosine‐based endocytic signals by clathrin AP‐2 complexes. , 1996, The EMBO journal.

[22]  J. Heuser,et al.  Effects of cytoplasmic acidification on clathrin lattice morphology , 1989, The Journal of cell biology.

[23]  L. Gilboa,et al.  Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors. , 2000, Molecular biology of the cell.

[24]  M. Robinson,et al.  Clathrin and adaptors. , 1998, Biochimica et biophysica acta.

[25]  Jeffrey L. Wrana,et al.  Mechanism of activation of the TGF-β receptor , 1994, Nature.

[26]  C. Arteaga,et al.  Processing of the transforming growth factor beta type I and II receptors. Biosynthesis and ligand-induced regulation. , 1997, The Journal of biological chemistry.

[27]  R. G. Anderson,et al.  Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation , 1993, The Journal of cell biology.

[28]  J. Doré,et al.  Distinct endocytic responses of heteromeric and homomeric transforming growth factor beta receptors. , 1997, Molecular biology of the cell.

[29]  I. Mellman Endocytosis and molecular sorting. , 1996, Annual review of cell and developmental biology.

[30]  J. Bonifacino,et al.  Interaction of tyrosine-based sorting signals with clathrin-associated proteins. , 1995, Science.

[31]  K. von Figura,et al.  The Leucine-based Sorting Motifs in the Cytoplasmic Domain of the Invariant Chain Are Recognized by the Clathrin Adaptors AP1 and AP2 and their Medium Chains* , 1999, The Journal of Biological Chemistry.

[32]  G. Carpenter,et al.  Interaction of activated EGF receptors with coated pit adaptins. , 1993, Science.

[33]  W. Webb,et al.  Mobility measurement by analysis of fluorescence photobleaching recovery kinetics. , 1976, Biophysical journal.

[34]  W. Webb,et al.  Dynamics of fluorescence marker concentration as a probe of mobility. , 1976, Biophysical journal.

[35]  K. Miyazono,et al.  Signaling inputs converge on nuclear effectors in TGF-β signaling , 2000 .

[36]  M. Roth,et al.  Evidence from lateral mobility studies for dynamic interactions of a mutant influenza hemagglutinin with coated pits , 1991, The Journal of cell biology.

[37]  H. Lodish,et al.  The types II and III transforming growth factor-beta receptors form homo-oligomers , 1994, The Journal of cell biology.

[38]  T. Kirchhausen Adaptors for clathrin-mediated traffic. , 1999, Annual review of cell and developmental biology.

[39]  M. O’Connor-McCourt,et al.  Transforming Growth Factor (TGF)-β1 Internalization , 2001, The Journal of Biological Chemistry.

[40]  T. Kirchhausen,et al.  Dileucine‐based sorting signals bind to the β chain of AP‐1 at a site distinct and regulated differently from the tyrosine‐based motif‐binding site , 1998, The EMBO journal.

[41]  M. Roth,et al.  Internalization-competent Influenza Hemagglutinin Mutants Form Complexes with Clathrin-deficient Multivalent AP-2 Oligomers in Live Cells* , 2001, The Journal of Biological Chemistry.

[42]  P. Evans,et al.  A Structural Explanation for the Binding of Multiple Ligands by the α-Adaptin Appendage Domain , 1999, Cell.

[43]  M. Roth,et al.  Dynamic or Stable Interactions of Influenza Hemagglutinin Mutants with Coated Pits , 1995, The Journal of Biological Chemistry.

[44]  J. Rizo,et al.  The LDL Receptor Clustering Motif Interacts with the Clathrin Terminal Domain in a Reverse Turn Conformation , 1998, The Journal of cell biology.

[45]  P R Evans,et al.  The structure and function of the β2‐adaptin appendage domain , 2000, The EMBO journal.

[46]  J. Doré,et al.  Differential Requirement for Type I and Type II Transforming Growth Factor β Receptor Kinase Activity in Ligand-mediated Receptor Endocytosis* , 1998, The Journal of Biological Chemistry.