Prevalence of Unknown Parental History of Disease in Either or Both Parents Prevalence of unknown history ( % ) Race Mother Father Both Disease group only only parents Hypertension Black

Background. The relation between self-reported parental disease and risk factor levels was examined in 2,637 black and 2,478 white men and women aged 18-30 years at the Coronary Artery Risk Development in Young Adults (CARDIA) Study baseline examination (1985-1986). Methods and Results. The prevalence of parental disease (at least one parent) in white versus black participants was 44% and 56% for hypertension, 47% and 44% for obesity, 16% and 13% for myocardial infarction, 11% and 17% for diabetes, and 6% and 10% for stroke, respectively. Among these young adults, parental hypertension was associated with higher sexand age-adjusted systolic and diastolic blood pressure levels. Parental myocardial infarction was associated with higher plasma cholesterol, higher blood pressure levels, and lower high density lipoprotein cholesterol levels in white participants. Parental diabetes was associated with higher fasting blood glucose and insulin levels in all race-sex groups and with higher triglycerides and lower high density lipoprotein cholesterol in black participants only. Parental history of obesity was related to less favorable ageand sex-adjusted lipid levels in white participants and higher blood pressure levels in black participants. Parental history of stroke

[1]  J. Albers,et al.  Quantitation of high density lipoproteins , 1978, Lipids.

[2]  J. Toole,et al.  Characteristics of stroke victims associated with early cardiovascular mortality in their children. , 1990, Journal of clinical epidemiology.

[3]  R. Prineas,et al.  Persistent elevation of blood pressure among children with a family history of hypertension: the Minneapolis Children's Blood Pressure Study. , 1988, Journal of hypertension.

[4]  S B Hulley,et al.  CARDIA: study design, recruitment, and some characteristics of the examined subjects. , 1988, Journal of clinical epidemiology.

[5]  J. Albers,et al.  Comparison of commercial kits for apoprotein A-I and apoprotein B with standardized apoprotein A-I and B radioimmunoassays performed at the Northwest Lipid Research Center. , 1988, Journal of lipid research.

[6]  D. Jacobs,et al.  Recruitment in the Coronary Artery Disease Risk Development in Young Adults (Cardia) Study. , 1987, Controlled clinical trials.

[7]  M. King,et al.  Environmental and behavioral determinants of fasting plasma glucose in women. A matched co-twin analysis. , 1987, American journal of epidemiology.

[8]  R. Gillum.  The association of body fat distribution with hypertension, hypertensive heart disease, coronary heart disease, diabetes and cardiovascular risk factors in men and women aged 18-79 years. , 1987, Journal of chronic diseases.

[9]  G. Burke,et al.  Blood pressure and echocardiographic measures in children: the Bogalusa Heart Study. , 1987, Circulation.

[10]  S. Garn.  Family-line and socioeconomic factors in fatness and obesity. , 2009, Nutrition reviews.

[11]  E. Barrett-Connor,et al.  Family history of heart attack: a modifiable risk factor? , 1986, Circulation.

[12]  G. Warnick.  Enzymatic methods for quantification of lipoprotein lipids. , 1986, Methods in enzymology.

[13]  L. Chambless,et al.  Progeny's lipid and lipoprotein levels by parental mortality. The Lipid Research Clinics Program Prevalence Study. , 1986, Circulation.

[14]  C. Sing,et al.  Aggregation of blood pressure in the families of children with labile high systolic blood pressure. The Muscatine Study. , 1986, American journal of epidemiology.

[15]  P. Bachorik,et al.  Precipitation methods for quantification of lipoproteins. , 1986, Methods in enzymology.

[16]  J. Nielsen,et al.  Echocardiographic variables in progeny of hypertensive and normotensive parents. , 2009, Acta medica Scandinavica. Supplementum.

[17]  C. Shear,et al.  The relationship between parental history of vascular disease and cardiovascular disease risk factors in children: the Bogalusa Heart Study. , 1985, American journal of epidemiology.

[18]  A. G. Fisher,et al.  Heritability of cardiac size: an echocardiographic and electrocardiographic study of monozygotic and dizygotic twins. , 1985, Circulation.

[19]  E. Barrett-Connor,et al.  Family history of heart attack as an independent predictor of death due to cardiovascular disease. , 1984, Circulation.

[20]  C. Sing,et al.  Total Cholesterol and Lipoproteins in School Children: Prediction of Coronary Heart Disease in Adult Relatives , 1983, Circulation.

[21]  K. K. Ibsen,et al.  CORONARY HEART RISK FACTORS IN 177 CHILDREN AND YOUNG ADULTS WHOSE FATHERS DIED FROM ISCHEMIC HEART DISEASE BEFORE AGE 45 , 1982, Acta paediatrica Scandinavica.

[22]  J. Albers,et al.  Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. , 1982, Clinical chemistry.

[23]  J. Neel,et al.  Identifying risk factors for diabetes in first degree relatives of non-insulin dependent diabetic patients. , 1982, American journal of epidemiology.

[24]  W. Kannel,et al.  Predicting coronary heart disease in siblings--a multivariate assessment: the Framingham Heart Study. , 1982, American journal of epidemiology.

[25]  R. Lauer,et al.  Left Ventricular Hypertrophy in Children with Blood Pressures in the Upper Quintile of the Distribution: The Muscatine Study , 1981, Hypertension.

[26]  C. Glueck,et al.  The relationship of parental history of myocardial infarction, hypertension, diabetes and stroke to coronary heart disease risk factors in their adult progeny. , 1981, American journal of epidemiology.

[27]  C. Sing,et al.  Familial aggregation of blood pressure and weight in adoptive families. I. Comparisons of blood pressure and weight statistics among families with adopted, natural, or both natural and adopted children. , 1979, American journal of epidemiology.

[28]  D. Thelle,et al.  The Tromso heart study: risk factors for coronary heart disease related to the occurrence of myocardial infarction in first degree relatives. , 1977, American journal of epidemiology.

[29]  W. Hazzard,et al.  Immunoassay of human plasma apolipoprotein B. , 1975, Metabolism: clinical and experimental.

[30]  R. Brand,et al.  The relationship of reported parental history to the incidence of coronary heart disease in the Western Collaborative Group Study. , 1970, American journal of epidemiology.

[31]  R. Levy,et al.  Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. , 1972, Clinical chemistry.

[32]  V. Herbert,et al.  Coated charcoal immunoassay of insulin. , 1965, The Journal of clinical endocrinology and metabolism.