The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

[1]  Jianbin Huang,et al.  The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP , 2005, Cell.

[2]  E. Nigg,et al.  The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1 , 2005, Oncogene.

[3]  Ying Li,et al.  Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats , 2005, Cell.

[4]  D. Gutmann,et al.  Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Jonathan Chernoff,et al.  NF2: The wizardry of merlin , 2003, Genes, chromosomes & cancer.

[6]  A. McClatchey.  Merlin and ERM proteins: unappreciated roles in cancer development? , 2003, Nature Reviews Cancer.

[7]  B. Wang,et al.  The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. , 2003, Genes & development.

[8]  H. Steller,et al.  Hippo and its mission for growth control , 2003, Nature Cell Biology.

[9]  N. Tapon,et al.  The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila , 2003, Nature Cell Biology.

[10]  Ryan S. Udan,et al.  Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway , 2003, Nature Cell Biology.

[11]  B. Hay,et al.  Coupling cell growth, proliferation, and death. Hippo weighs in. , 2003, Developmental cell.

[12]  Shian Wu,et al.  hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts , 2003, Cell.

[13]  I. Hariharan,et al.  The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis , 2003, Cell.

[14]  M. Giovannini,et al.  NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. , 2003, Genes & development.

[15]  P Robin Hiesinger,et al.  Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila , 2002, Development.

[16]  D. Haber,et al.  salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell Lines , 2002, Cell.

[17]  A. Bretscher,et al.  ERM proteins and merlin: integrators at the cell cortex , 2002, Nature Reviews Molecular Cell Biology.

[18]  A. Ciechanover,et al.  Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1 , 2002, Nature Cell Biology.

[19]  H. Meinhardt,et al.  Developmental biology: Modular feedback , 2002, Nature.

[20]  L. Johnston,et al.  Control of growth and organ size in Drosophila , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

[21]  N. Baker.  Cell proliferation, survival, and death in the Drosophila eye. , 2001, Seminars in cell & developmental biology.

[22]  C. Potter,et al.  Drosophila Tsc1 Functions with Tsc2 to Antagonize Insulin Signaling in Regulating Cell Growth, Cell Proliferation, and Organ Size , 2001, Cell.

[23]  B. Dickson,et al.  The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation , 2001, Cell.

[24]  Norinobu M. Watanabe,et al.  The Ste20 group kinases as regulators of MAP kinase cascades. , 2001, Trends in cell biology.

[25]  L. Jones,et al.  Tissue-specific regulation of cyclin E transcription during Drosophila melanogaster embryogenesis. , 2000, Development.

[26]  M. Mlodzik,et al.  The Drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during development , 2000, Mechanisms of Development.

[27]  R. Fehon,et al.  The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. , 2000, Development.

[28]  B. Dickson,et al.  Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. , 2000, Development.

[29]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[30]  M. S. St John,et al.  The role of lats in cell cycle regulation and tumorigenesis. , 1999, Biochimica et biophysica acta.

[31]  W. Tao,et al.  Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction , 1999, Nature Genetics.

[32]  W. Tao,et al.  Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity , 1999, Nature Genetics.

[33]  I. Conlon,et al.  Size Control in Animal Development , 1999, Cell.

[34]  R. Fehon,et al.  Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular Localization , 1998, The Journal of cell biology.

[35]  T. Jacks,et al.  Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. , 1998, Genes & development.

[36]  P. Bryant,et al.  Expanded functions in the apical cell domain to regulate the growth rate of imaginal discs. , 1997, Developmental genetics.

[37]  Gerald M. Rubin,et al.  Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death , 1995, Cell.

[38]  T Marty,et al.  Ectopic cyclin E expression induces premature entry into S phase and disrupts pattern formation in the Drosophila eye imaginal disc. , 1995, Development.

[39]  G. Rouleau,et al.  The neurofibromatosis type 2 gene product, schwannomin, suppresses growth of NIH 3T3 cells. , 1995, Cancer research.

[40]  T. Xu,et al.  Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. , 1995, Development.

[41]  P J Bryant,et al.  The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. , 1995, Genes & development.

[42]  A. Laughon,et al.  Expanded: a gene involved in the control of cell proliferation in imaginal discs. , 1993, Development.

[43]  S. Pulst,et al.  Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2 , 1993, Nature.

[44]  N. Perrimon,et al.  Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. , 1993, Development.

[45]  G. Rubin,et al.  Analysis of genetic mosaics in developing and adult Drosophila tissues. , 1993, Development.

[46]  J. Haines,et al.  A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor , 1993, Cell.

[47]  Konrad Basler,et al.  Organizing activity of wingless protein in Drosophila , 1993, Cell.

[48]  T. Wolff,et al.  The beginning of pattern formation in the Drosophila compound eye: the morphogenetic furrow and the second mitotic wave. , 1991, Development.