Pyrvinium targets autophagy addiction to promote cancer cell death

[1]  Shengbing Huang,et al.  The Role of Autophagy in Cancer: Therapeutic Implications , 2011, Molecular Cancer Therapeutics.

[2]  P. D. Hart,et al.  Ammonium chloride, an inhibitor of phagosome-lysosome fusion in macrophages, concurrently induces phagosome-endosome fusion, and opens a novel pathway: studies of a pathogenic mycobacterium and a nonpathogenic yeast , 1991, The Journal of experimental medicine.

[3]  D. Hardie,et al.  AMPK and Raptor: matching cell growth to energy supply. , 2008, Molecular cell.

[4]  Yuquan Wei,et al.  Proteomics Identification of ITGB3 as a Key Regulator in Reactive Oxygen Species-induced Migration and Invasion of Colorectal Cancer Cells* , 2011, Molecular & Cellular Proteomics.

[5]  Nicholas J. Toepfer,et al.  Atorvastatin induces autophagy in prostate cancer PC3 cells through activation of LC3 transcription , 2011, Cancer biology & therapy.

[6]  H. Ke,et al.  Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13 , 2011, Cell.

[7]  Binjie Zhang,et al.  Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages , 2012, Journal of Cell Science.

[8]  K. Otsu,et al.  Discovery of Atg5/Atg7-independent alternative macroautophagy , 2009, Nature.

[9]  D. Rubinsztein,et al.  Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease , 2010, Human molecular genetics.

[10]  S. Gygi,et al.  Network organization of the human autophagy system , 2010, Nature.

[11]  D. Ginsberg,et al.  E2F1 regulates autophagy and the transcription of autophagy genes , 2008, Oncogene.

[12]  H. Esumi,et al.  Antitumor activity of pyrvinium pamoate, 6‐(dimethylamino)‐2‐[2‐(2,5‐dimethyl‐1‐phenyl‐1H‐pyrrol‐3‐yl)ethenyl]‐1‐methyl‐quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation , 2004, Cancer science.

[13]  D. Rubinsztein,et al.  Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. , 2008, Nature chemical biology.

[14]  C. Chong,et al.  Efficacy of Pyrvinium Pamoate against Cryptosporidium parvum Infection In Vitro and in a Neonatal Mouse Model , 2008, Antimicrobial Agents and Chemotherapy.

[15]  H. Esumi,et al.  An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system--a unique mitochondrial energy metabolism in tumour microenvironments. , 2012, Journal of biochemistry.

[16]  D. Lenschow,et al.  Chikungunya virus–induced autophagy delays caspase-dependent cell death , 2012, The Journal of experimental medicine.

[17]  Hui Zhang,et al.  Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity , 2010, Nature Cell Biology.

[18]  Brij B. Singh,et al.  Elevated Inflammatory Response in Caveolin-1-deficient Mice with Pseudomonas aeruginosa Infection Is Mediated by STAT3 Protein and Nuclear Factor κB (NF-κB)* , 2011, The Journal of Biological Chemistry.

[19]  J. Mancias,et al.  Targeting Autophagy Addiction in Cancer , 2011, Oncotarget.

[20]  G. Steele,et al.  Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[21]  Takeshi Noda,et al.  LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.

[22]  David J Foran,et al.  Therapeutic starvation and autophagy in prostate cancer: A new paradigm for targeting metabolism in cancer therapy , 2008, The Prostate.

[23]  K. Ryan,et al.  Autophagy and cancer. , 2012, Cold Spring Harbor perspectives in biology.

[24]  R. Kurzrock,et al.  Autophagy as a target for anticancer therapy , 2011, Nature Reviews Clinical Oncology.

[25]  N. Mizushima,et al.  How to Interpret LC3 Immunoblotting , 2007, Autophagy.

[26]  William A Weiss,et al.  Principles and Current Strategies for Targeting Autophagy for Cancer Treatment , 2011, Clinical Cancer Research.

[27]  K. Garber Inducing indigestion: companies embrace autophagy inhibitors. , 2011, Journal of the National Cancer Institute.

[28]  G. Evan,et al.  Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. , 2007, The Journal of clinical investigation.

[29]  Bruce J. Melancon,et al.  Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. , 2010, Nature chemical biology.

[30]  S. Emr,et al.  Autophagy as a regulated pathway of cellular degradation. , 2000, Science.

[31]  Y. Harada,et al.  Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3. , 2012, Cancer letters.

[32]  B. Viollet,et al.  AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 , 2011, Nature Cell Biology.

[33]  Yuquan Wei,et al.  Mechanism of Cancer Cell Adaptation to Metabolic Stress , 2009, Molecular & Cellular Proteomics.

[34]  Takeshi Tokuhisa,et al.  The role of autophagy during the early neonatal starvation period , 2004, Nature.

[35]  J. Stockert,et al.  DNA fluorescence induced by polymethine cation pyrvinium binding , 1991, The Histochemical Journal.

[36]  Tao Zhang,et al.  Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling , 2011, Autophagy.

[37]  B. Hann,et al.  Non-competitive androgen receptor inhibition in vitro and in vivo , 2009, Proceedings of the National Academy of Sciences.

[38]  H. Lubs,et al.  Animal Responses to 2-Deoxy-D-Glucose Administration , 1958, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[39]  A. Cuervo,et al.  Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway. , 2012, Cell reports.

[40]  Timothy H. Davis,et al.  Pyrvinium Targets the Unfolded Protein Response to Hypoglycemia and Its Anti-Tumor Activity Is Enhanced by Combination Therapy , 2008, PloS one.