Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis
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G. Kristiansen | G. Camenisch | R. Wenger | P. Schraml | D. Stiehl | L. Borsig | M. Bordoli | S. Hausladen | M. R. Bordoli | Roland H. Wenger | R. H. Wenger | Silke Hausladen | Glen Kristiansen
[1] A. Horwitz,et al. BRCA1 represses amphiregulin gene expression. , 2010, Cancer research.
[2] Jing Fang,et al. Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity. , 2010, Gastroenterology.
[3] C. Holterman,et al. Human cancers converge at the HIF-2α oncogenic axis , 2009, Proceedings of the National Academy of Sciences.
[4] William C Hahn,et al. Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. , 2009, Cancer cell.
[5] H. Moch,et al. Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response , 2009, Oncogene.
[6] Howard Y. Chang,et al. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. , 2009, Cancer cell.
[7] Frederik De Smet,et al. Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization , 2009, Cell.
[8] P. Bedossa,et al. Overexpression of the Oxygen Sensors PHD-1, PHD-2, PHD-3, and FIH Is Associated with Tumor Aggressiveness in Pancreatic Endocrine Tumors , 2008, Clinical Cancer Research.
[9] K. Miyazono,et al. Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.
[10] M. Kiupel,et al. The Biphasic Role of the Hypoxia-Inducible Factor Prolyl-4-Hydroxylase, PHD2, in Modulating Tumor-Forming Potential , 2008, Molecular Cancer Research.
[11] S. Ethier,et al. Amphiregulin as a Novel Target for Breast Cancer Therapy , 2008, Journal of Mammary Gland Biology and Neoplasia.
[12] J. Howlin,et al. Amphiregulin: Role in Mammary Gland Development and Breast Cancer , 2008, Journal of Mammary Gland Biology and Neoplasia.
[13] F. Soncin,et al. HIF-2α specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites , 2007, Oncogene.
[14] K. Takeda,et al. Essential Role for Prolyl Hydroxylase Domain Protein 2 in Oxygen Homeostasis of the Adult Vascular System , 2007, Circulation.
[15] D. Jäger,et al. NY‐ESO‐1 protein expression in primary breast carcinoma and metastases—correlation with CD8+ T‐cell and CD79a+ plasmacytic/B‐cell infiltration , 2007, International journal of cancer.
[16] P. Hasgall,et al. The Peptidyl Prolyl cis/trans Isomerase FKBP38 Determines Hypoxia-Inducible Transcription Factor Prolyl-4-Hydroxylase PHD2 Protein Stability , 2007, Molecular and Cellular Biology.
[17] Roland H Wenger,et al. Increased Prolyl 4-Hydroxylase Domain Proteins Compensate for Decreased Oxygen Levels , 2006, Journal of Biological Chemistry.
[18] J. Pouysségur,et al. Hypoxia signalling in cancer and approaches to enforce tumour regression , 2006, Nature.
[19] H. Mitsuhashi,et al. Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292. , 2006, Life sciences.
[20] N. Wake,et al. Induction of human endometrial cancer cell senescence through modulation of HIF‐1α activity by EGLN1 , 2006, International journal of cancer.
[21] P. Kronqvist,et al. Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. , 2006, Clinical cancer research : an official journal of the American Association for Cancer Research.
[22] M. Leonard,et al. Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner. , 2006, American journal of physiology. Cell physiology.
[23] G. Camenisch,et al. Integration of Oxygen Signaling at the Consensus HRE , 2005, Science's STKE.
[24] W. Kaelin,et al. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. , 2005, Cancer cell.
[25] W. Jelkmann,et al. Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. , 2005, The Biochemical journal.
[26] J. Brown,et al. Exploiting tumour hypoxia in cancer treatment , 2004, Nature Reviews Cancer.
[27] F. Walther,et al. Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress. , 2004, Free radical biology & medicine.
[28] Varda Rotter,et al. Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth. , 2003, Cancer research.
[29] G. Semenza. Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.
[30] pierre-Marie Martin,et al. Transforming growth factor β‐1 and amphiregulin act in synergy to increase the production of urokinase‐type plasminogen activator in transformed breast epithelial cells , 2003 .
[31] K. Eckardt,et al. Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[32] Mircea Ivan,et al. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[33] R. Wenger,et al. Cellular adaptation to hypoxia: O2‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O2‐regulated gene expression , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[34] S. McKnight,et al. A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF , 2001, Science.
[35] Michael I. Wilson,et al. C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation , 2001, Cell.
[36] Michael I. Wilson,et al. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation , 2001, Science.
[37] G. Semenza,et al. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. , 2001, Cancer research.
[38] M. Gassmann,et al. Epolones induce erythropoietin expression via hypoxia-inducible factor-1α activation , 2000 .
[39] D A Hilton,et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. , 1999, Cancer research.
[40] G. Millot,et al. Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line , 1999, Oncogene.
[41] W. Gerald,et al. The Wilms Tumor Suppressor WT1 Encodes a Transcriptional Activator of amphiregulin , 1999, Cell.
[42] David C. Lee,et al. Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. , 1999, Development.
[43] C. Wykoff,et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis , 1999, Nature.
[44] M. Gassmann,et al. General applicability of chicken egg yolk antibodies: the performance of IgY immunoglobulins raised against the hypoxia‐inducible factor 1α , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[45] A. Harris,et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. , 1998, Blood.
[46] M. Merino,et al. Differential immunohistochemical detection of transforming growth factor α, amphiregulin and CRIPTO in human normal and malignant breast tissues , 1996, International journal of cancer.
[47] N. Normanno,et al. Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines. , 1995, Endocrinology.
[48] R. Coffey,et al. Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family. , 1994, The Journal of biological chemistry.
[49] G. Merlo,et al. Expression of transforming growth factor alpha, amphiregulin and cripto-1 in human breast carcinomas. , 1994, British Journal of Cancer.
[50] I. Ellis,et al. Method for grading breast cancer. , 1993, Journal of clinical pathology.
[51] C. Disteche,et al. The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity , 1990, Molecular and cellular biology.
[52] G. Todaro,et al. Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[53] pierre-Marie Martin,et al. Transforming growth factor beta-1 and amphiregulin act in synergy to increase the production of urokinase-type plasminogen activator in transformed breast epithelial cells. , 2003, International journal of cancer.