Leukemia with Down's syndrome: translocation between chromosomes 1 and 19 in acute myelomonocytic leukemia following transient congenital myeloproliferative syndrome.

A girl with Down's syndrome was born with a myeloproliferative disorder. The child had spontaneous regression of the myeloproliferation, with acute leukemia developing at a later date. Morphologic, cytochemical, immunologic, and immunoglobulin gene configuration studies all supported the diagnosis of acute nonlymphocytic leukemia. High-resolution chromosome studies revealed that the leukemic cells consistently contained a translocation between chromosomes 1 and 19: der(19)t(1;19)(q25;p13). Spontaneous regression of the transient myeloproliferative syndrome of the newborn with Down's syndrome may not always be permanent, and the transient myeloproliferative syndrome may sometimes represent an early sign of acute nonlymphocytic leukemia.

[1]  F. Hecht,et al.  Chromosome clues to acute leukemia in Down's syndrome. , 1986, Cancer genetics and cytogenetics.

[2]  R. Grindley,et al.  Translocation between chromosomes 1 and 19 in acute lymphoblastic leukemia. , 1984, Cancer genetics and cytogenetics.

[3]  R. Parmley,et al.  Pre-B cell leukemia associated with chromosome translocation 1;19. , 1984, Blood.

[4]  R. Warnke,et al.  Monoclonality of lymphoproliferative lesions in cardiac-transplant recipients. Clonal analysis based on immunoglobulin-gene rearrangements. , 1984, The New England journal of medicine.

[5]  A. Look,et al.  New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia , 1984, Cell.

[6]  R. Warnke,et al.  Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[7]  J. Rowley.  DOWN SYNDROME AND ACUTE LEUKAEMIA: INCREASED RISK MAY BE DUE TO TRISOMY 21 , 1981, The Lancet.

[8]  Y. Kaneko,et al.  Chromosome abnormalities in Down's syndrome patients with acute leukemia. , 1981, Blood.

[9]  H. Weinstein.  Congenital leukaemia and the neonatal myeloproliferative disorders associated with Down's syndrome. , 1978, Clinics in haematology.

[10]  R. Engel,et al.  TRANSIENT CONGENITAL LEUKEMIA IN 7 INFANTS WITH MONGOLISM. , 1964, The Journal of pediatrics.

[11]  R. Rosen,et al.  LEUKEMIA VERSUS "INEFFECTIVE REGULATION OF GRANULOPOIESIS" IN MONGOLISM. , 1964, The Journal of pediatrics.

[12]  J. Desforges,et al.  Ineffective regulation of granulopoiesis masquerading as congenital leukemia in a mongoloid child. , 1963, The Journal of pediatrics.

[13]  R. Good,et al.  Simultaneous occurrence of mongolism and leukemia; report of a nationwide survey. , 1957, A.M.A. journal of diseases of children.