Failure of ICD-9-CM codes to identify patients with comorbid chronic kidney disease in diabetes.

OBJECTIVE To determine prevalence of chronic kidney disease (CKD) in patients with diabetes, and accuracy of International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) codes to identify such patients. DATA SOURCES/STUDY SETTING Secondary data from 1999 to 2000. We linked all inpatient and outpatient administrative and clinical records of U.S. veterans with diabetes dually enrolled in Medicare and the Veterans Administration (VA) health care systems. STUDY DESIGN We used a cross-sectional, observational design to determine the sensitivity and specificity of renal-related ICD-9-CM diagnosis codes in identifying individuals with chronic kidney disease. DATA COLLECTION/EXTRACTION METHODS We estimated glomerular filtration rate (eGFR) from serum creatinine and defined CKD as Stage 3, 4, or 5 CKD by eGFR criterion according to the Kidney Disease Outcomes Quality Initiative guidelines. Renal-related ICD-9-CM codes were grouped by algorithm. PRINCIPAL FINDINGS Prevalence of CKD was 31.6 percent in the veteran sample with diabetes. Depending on the detail of the algorithm, only 20.2 to 42.4 percent of individuals with CKD received a renal-related diagnosis code in either VA or Medicare records over 1 year. Specificity of renal codes for CKD ranged from 93.2 to 99.4 percent. Patients hospitalized in VA facilities were slightly more likely to be correctly coded for CKD than patients hospitalized in facilities reimbursed by Medicare (OR 5.4 versus 4.1, p=.0330) CONCLUSIONS CKD is a common comorbidity for patients with diabetes in the VA system. Diagnosis codes in administrative records from Medicare and VA systems are insensitive, but specific markers for patients with CKD.

[1]  L. M. Lou-Arnal,et al.  Mild renal insufficiency as a cardiovascular risk factor in non-proteinuric type II diabetes. , 2004, Diabetes research and clinical practice.

[2]  M. Mcclellan,et al.  Association of Renal Insufficiency with Treatment and Outcomes after Myocardial Infarction in Elderly Patients , 2002, Annals of Internal Medicine.

[3]  C. Gullion,et al.  Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. , 2004, Archives of internal medicine.

[4]  B. Myers,et al.  Acute renal failure following cardiac surgery. , 1979, The Journal of thoracic and cardiovascular surgery.

[5]  E. Lewis,et al.  Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. , 2001, The New England journal of medicine.

[6]  A. Jaffe,et al.  Acute Myocardial Infarction and Renal Dysfunction: A High-Risk Combination , 2002, Annals of Internal Medicine.

[7]  The use of administrative data as the first step in the continuous quality improvement process. , 1996, American journal of medical quality : the official journal of the American College of Medical Quality.

[8]  R. Califf,et al.  Outcomes of Patients With Chronic Renal Insufficiency in the Bypass Angioplasty Revascularization Investigation , 2002, Circulation.

[9]  A Fournier,et al.  The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. , 1994, The New England journal of medicine.

[10]  M. Laakso,et al.  Proteinuria predicts stroke and other atherosclerotic vascular disease events in nondiabetic and non-insulin-dependent diabetic subjects. , 1996, Stroke.

[11]  E S Fisher,et al.  Overcoming potential pitfalls in the use of Medicare data for epidemiologic research. , 1990, American journal of public health.

[12]  G. Dangas,et al.  Acute renal failure requiring dialysis after percutaneous coronary interventions , 2001, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[13]  Deeb N Salem,et al.  Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: a pooled analysis of community-based studies. , 2004, Journal of the American Society of Nephrology : JASN.

[14]  A. Levin,et al.  Cardiac risk factors and the use of cardioprotective medications in patients with chronic renal insufficiency. , 2001, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[15]  Jeannine S. Schiller,et al.  Summary health statistics for U.S. adults: National Health Interview Survey, 2002. , 2004, Vital and health statistics. Series 10, Data from the National Health Survey.

[16]  G. Eknoyan,et al.  National Kidney Foundation Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification , 2003, Annals of Internal Medicine.

[17]  D. Battleman,et al.  Economic consequences of renal dysfunction among cardiopulmonary bypass surgery patients: a hospital-based perspective. , 2003, Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.

[18]  Charles E. McCulloch,et al.  CHRONIC KIDNEY DISEASE AND THE RISKS OF DEATH, CARDIOVASCULAR EVENTS, AND HOSPITALIZATION , 2004 .

[19]  Thomas E. Moritz,et al.  Renal failure predisposes patients to adverse outcome after coronary artery bypass surgery , 1999 .

[20]  M. Mack,et al.  Current status and outcomes of coronary revascularization 1999 to 2002: 148,396 surgical and percutaneous procedures. , 2004, The Annals of thoracic surgery.

[21]  A. Levey,et al.  A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation , 1999, Annals of Internal Medicine.

[22]  B. Yawn,et al.  Identifying Persons with Diabetes Using Medicare Claims Data , 1999, American journal of medical quality : the official journal of the American College of Medical Quality.

[23]  S. Arrigain,et al.  Influence of renal dysfunction on mortality after cardiac surgery: modifying effect of preoperative renal function. , 2005, Kidney international.

[24]  B. Brenner,et al.  Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. , 2001, The New England journal of medicine.

[25]  A. S. Appel,et al.  Acute Renal Failure , 1960, Advances in Experimental Medicine and Biology.

[26]  W. O’Neill,et al.  Acute renal failure after coronary intervention: incidence, risk factors, and relationship to mortality. , 1997, The American journal of medicine.

[27]  P. Whelton,et al.  Risk of End-stage Renal Disease in Diabetes Mellitus: A Prospective Cohort Study of Men Screened for MRFIT , 1997 .

[28]  L. Iezzoni Risk Adjustment for Measuring Healthcare Outcomes , 1994 .

[29]  G. Reiber,et al.  Diabetes and renal disease in veterans. , 2004, Diabetes care.

[30]  R. Bain,et al.  The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. , 1993, The New England journal of medicine.

[31]  K. Flegal,et al.  Prevalence of Diabetes, Impaired Fasting Glucose, and Impaired Glucose Tolerance in U.S. Adults: The Third National Health and Nutrition Examination Survey, 1988–1994 , 1998, Diabetes Care.

[32]  Quan Dong Nguyen,et al.  Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetes mellitus. , 2003, JAMA.

[33]  M. Escola Fortuny [Renal insufficiency]. , 1985, Revista de enfermeria.

[34]  S. Yusuf,et al.  Renal Insufficiency as a Predictor of Cardiovascular Outcomes and the Impact of Ramipril: The HOPE Randomized Trial , 2001, Annals of Internal Medicine.

[35]  A. Folsom,et al.  Trends in the sensitivity, positive predictive value, false-positive rate, and comparability ratio of hospital discharge diagnosis codes for acute myocardial infarction in four US communities, 1987-2000. , 2004, American journal of epidemiology.

[36]  W. McClellan,et al.  Renal insufficiency and anemia are independent risk factors for death among patients with acute myocardial infarction. , 2003, Kidney international.

[37]  John R. Pleis,et al.  Summary health statistics for U.S. adults: National Health Interview Survey, 1999. , 2003, Vital and health statistics. Series 10, Data from the National Health Survey.

[38]  Donald R. Miller,et al.  Who has diabetes? Best estimates of diabetes prevalence in the Department of Veterans Affairs based on computerized patient data. , 2004, Diabetes care.

[39]  PREVALENCE OF DIABETES. , 1929, Science.

[40]  J. Whitworth,et al.  Acute renal failure following cardiac surgery: incidence, outcomes and risk factors. , 1995, Australian and New Zealand journal of medicine.

[41]  L. Muhlbaier,et al.  Using Medicare Claims for Outcomes Research , 1994, Medical care.

[42]  O. Pedersen,et al.  Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised study , 1999, The Lancet.

[43]  Kdoqi Disclaimer K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[44]  P. Whelton,et al.  Risk of end-stage renal disease in diabetes mellitus: a prospective cohort study of men screened for MRFIT. Multiple Risk Factor Intervention Trial. , 1997, JAMA.

[45]  E. Lamb,et al.  Estimation of Glomerular Filtration Rate in Older Patients with Chronic Renal Insufficiency: Is the Modification of Diet in Renal Disease Formula an Improvement? , 2003, Journal of the American Geriatrics Society.

[46]  Robert J. Anderson,et al.  Clinical Nephrology – Epidemiology – Clinical TrialsRenal failure predisposes patients to adverse outcome after coronary artery bypass surgery , 1999 .

[47]  E. Fisher,et al.  The accuracy of Medicare's hospital claims data: progress has been made, but problems remain. , 1992, American journal of public health.