Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice
暂无分享,去创建一个
Yurong Xin | E. Chiao | B. Zambrowicz | Evangelos Pefanis | G. Droguett | Sven Moller-Tank | G. Gong | D. Frendewey | S. Hartford | Qi Su | Charleen Hunt | J. Altarejos | Timothy Hanna | Maria del Pilar Molina-Portela | M. Drummond | Derek White | Clarissa Herman | Jarrell Wiley | H. Brown | Dennis Voronin | Hien Nguyen | Keith Crosby | Jeffery Haines | Sarah Cancelarich | Ryan M. Malpass | Jacqueline Buckley
[1] B. Nayagam,et al. Organotypic Culture of Neonatal Murine Inner Ear Explants , 2019, Front. Cell. Neurosci..
[2] W. Stanford,et al. The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier. , 2019, Molecular therapy : the journal of the American Society of Gene Therapy.
[3] C. Tin,et al. Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa , 2019, Molecular therapy. Nucleic acids.
[4] Navneet Matharu,et al. CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency , 2019, Science.
[5] S. Saad,et al. Comparison of different methods to overexpress large genes , 2018, Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale.
[6] L. Marraffini,et al. Molecular mechanisms of CRISPR–Cas spacer acquisition , 2018, Nature Reviews Microbiology.
[7] Max A. Horlbeck,et al. Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform , 2018, Hepatology.
[8] S. Fazio,et al. PCSK9: From Basic Science Discoveries to Clinical Trials , 2018, Circulation research.
[9] G. Church,et al. Rational design of a compact CRISPR-Cas9 activator for AAV-mediated delivery , 2018 .
[10] M. K. Jensen. Design principles for nuclease-deficient CRISPR-based transcriptional regulators , 2018, FEMS Yeast Research.
[11] Hyoung-Kyu kim,et al. Alternative splicing isoforms in health and disease , 2018, Pflügers Archiv - European Journal of Physiology.
[12] K. Hu,et al. Sleeping Beauty transposon integrates into non-TA dinucleotides , 2018, Mobile DNA.
[13] J. Michael Cherry,et al. The Encyclopedia of DNA elements (ENCODE): data portal update , 2017, Nucleic Acids Res..
[14] R. Parker,et al. An improved MS2 system for accurate reporting of the mRNA life cycle , 2017, Nature Methods.
[15] Huatai Xu,et al. In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice , 2018, Nature Neuroscience.
[16] Y. Suh,et al. In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human disease , 2017, F1000Research.
[17] C. R. Esteban,et al. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation , 2017, Cell.
[18] B. Emanuelli,et al. Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA , 2017, Molecular metabolism.
[19] Hao Yin,et al. Delivery technologies for genome editing , 2017, Nature Reviews Drug Discovery.
[20] Darjus F. Tschaharganeh,et al. Using CRISPR/Cas to study gene function and model disease in vivo , 2016, The FEBS journal.
[21] J. Joly,et al. Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR , 2016, Genome Biology.
[22] J. Metzger,et al. Inexpensive, serotype-independent protocol for native and bioengineered recombinant adeno-associated virus purification , 2016, Journal of biological methods.
[23] Antonia A. Dominguez,et al. Transcriptional regulation of hepatic lipogenesis , 2015, Nature Reviews Molecular Cell Biology.
[24] M. Benson,et al. Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis. , 2015, Journal of the American College of Cardiology.
[25] M. Krempf,et al. Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody , 2015, Circulation. Cardiovascular genetics.
[26] J. Goutman,et al. Cochlear hair cells: The sound‐sensing machines , 2015, FEBS letters.
[27] J. Rinn,et al. Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs , 2015, PloS one.
[28] David A. Scott,et al. In vivo genome editing using Staphylococcus aureus Cas9 , 2015, Nature.
[29] Alexandro E. Trevino,et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex , 2014, Nature.
[30] Dominik Niopek,et al. CRISPR/Cas9-mediated genome engineering: an adeno-associated viral (AAV) vector toolbox. , 2014, Biotechnology journal.
[31] Y. Ando,et al. Recent advances in transthyretin amyloidosis therapy , 2014, Translational Neurodegeneration.
[32] J. C. Belmonte,et al. Regenerative medicine: Transdifferentiation in vivo , 2013, Cell Research.
[33] Chengyu Liu. Strategies for Designing Transgenic DNA Constructs , 2013, Methods in molecular biology.
[34] N. Ahituv,et al. The hydrodynamic tail vein assay as a tool for the study of liver promoters and enhancers. , 2013, Methods in molecular biology.
[35] T. R. Van De Water,et al. A Novel Organ of Corti Explant Model for the Study of Cochlear Implantation Trauma , 2012, Anatomical record.
[36] ENCODEConsortium,et al. An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.
[37] G. Prelich. Gene Overexpression: Uses, Mechanisms, and Interpretation , 2012, Genetics.
[38] M. Kay,et al. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. , 2011, The Journal of clinical investigation.
[39] Liqun Luo,et al. Site-specific integrase-mediated transgenesis in mice via pronuclear injection , 2011, Proceedings of the National Academy of Sciences.
[40] J. Deng,et al. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine , 2011, Nature Genetics.
[41] Aaron Klug,et al. The discovery of zinc fingers and their development for practical applications in gene regulation and genome manipulation , 2010, Quarterly Reviews of Biophysics.
[42] Jon W. Huss,et al. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources , 2009, Genome Biology.
[43] Jianxin Xie,et al. The Creb1 coactivator Crtc1 is required for energy balance and fertility , 2008, Nature Medicine.
[44] A. Su,et al. Expression analysis of G Protein-Coupled Receptors in mouse macrophages , 2008, Immunome research.
[45] G. Yancopoulos,et al. F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses , 2007, Nature Biotechnology.
[46] Hui Yu,et al. Systematic Analysis of Head-to-Head Gene Organization: Evolutionary Conservation and Potential Biological Relevance , 2006, PLoS Comput. Biol..
[47] C. Barbas,et al. Exploring Strategies for the Design of Artificial Transcription Factors , 2005, Journal of Biological Chemistry.
[48] S. Batalov,et al. A gene atlas of the mouse and human protein-encoding transcriptomes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[49] M. Kolot,et al. Site-specific recombination in mammalian cells expressing the Int recombinase of bacteriophage HK022 – Site-specific recombination in mammalian cells promoted by a phage integrase , 1999, Molecular Biology Reports.
[50] A. F. Stewart,et al. High-throughput engineering of the mouse genome coupled with high-resolution expression analysis , 2003, Nature Biotechnology.
[51] Tom H. Pringle,et al. The human genome browser at UCSC. , 2002, Genome research.
[52] W. J. Kent,et al. BLAT--the BLAST-like alignment tool. , 2002, Genome research.
[53] Eric C. Olivares,et al. A phage integrase directs efficient site-specific integration in human cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[54] Dexi Liu,et al. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA , 1999, Gene Therapy.
[55] B. Byrne,et al. Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield , 1999, Gene Therapy.
[56] L A Herzenberg,et al. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[57] Philippe Soriano,et al. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. , 1991, Genes & development.
[58] P. Wise,et al. Diurnal pattern of proopiomelanocortin gene expression in the arcuate nucleus of proestrous, ovariectomized, and steroid-treated rats: a possible role in cyclic luteinizing hormone secretion. , 1990, Molecular endocrinology.
[59] A. Joyner,et al. Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. , 1989, Science.